ZBED5_HUMAN
ID ZBED5_HUMAN Reviewed; 693 AA.
AC Q49AG3; B2RCC1; Q05D82; Q86WW3; Q9NT24; Q9UBJ4;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Zinc finger BED domain-containing protein 5;
DE AltName: Full=Transposon-derived Buster1 transposase-like protein;
GN Name=ZBED5; Synonyms=Buster1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT VAL-480.
RX PubMed=10607616; DOI=10.1016/s0959-437x(99)00031-3;
RA Smit A.F.A.;
RT "Interspersed repeats and other mementos of transposable elements in
RT mammalian genomes.";
RL Curr. Opin. Genet. Dev. 9:657-663(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- MISCELLANEOUS: May be derived from an ancient transposon that has lost
CC its ability to translocate.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17803.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAH47754.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF205600; AAF18454.1; -; mRNA.
DR EMBL; AF205601; AAF18455.1; -; Genomic_DNA.
DR EMBL; AK315033; BAG37518.1; -; mRNA.
DR EMBL; AC069360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68550.1; -; Genomic_DNA.
DR EMBL; BC017803; AAH17803.1; ALT_SEQ; mRNA.
DR EMBL; BC047754; AAH47754.1; ALT_FRAME; mRNA.
DR EMBL; AL137577; CAB70820.2; -; mRNA.
DR PIR; T46273; T46273.
DR RefSeq; NP_001137139.1; NM_001143667.1.
DR RefSeq; NP_067034.2; NM_021211.3.
DR AlphaFoldDB; Q49AG3; -.
DR BioGRID; 121816; 5.
DR IntAct; Q49AG3; 6.
DR MINT; Q49AG3; -.
DR STRING; 9606.ENSP00000398106; -.
DR iPTMnet; Q49AG3; -.
DR PhosphoSitePlus; Q49AG3; -.
DR SwissPalm; Q49AG3; -.
DR BioMuta; ZBED5; -.
DR DMDM; 150416326; -.
DR EPD; Q49AG3; -.
DR jPOST; Q49AG3; -.
DR MassIVE; Q49AG3; -.
DR MaxQB; Q49AG3; -.
DR PaxDb; Q49AG3; -.
DR PeptideAtlas; Q49AG3; -.
DR PRIDE; Q49AG3; -.
DR ProteomicsDB; 62042; -.
DR Antibodypedia; 24475; 62 antibodies from 12 providers.
DR DNASU; 58486; -.
DR Ensembl; ENST00000413761.7; ENSP00000415939.2; ENSG00000236287.8.
DR Ensembl; ENST00000432999.6; ENSP00000398106.2; ENSG00000236287.8.
DR GeneID; 58486; -.
DR KEGG; hsa:58486; -.
DR MANE-Select; ENST00000413761.7; ENSP00000415939.2; NM_001143667.2; NP_001137139.1.
DR UCSC; uc001mji.4; human.
DR CTD; 58486; -.
DR GeneCards; ZBED5; -.
DR HGNC; HGNC:30803; ZBED5.
DR HPA; ENSG00000236287; Low tissue specificity.
DR MIM; 615251; gene.
DR neXtProt; NX_Q49AG3; -.
DR OpenTargets; ENSG00000236287; -.
DR PharmGKB; PA147357120; -.
DR VEuPathDB; HostDB:ENSG00000236287; -.
DR eggNOG; ENOG502QT83; Eukaryota.
DR GeneTree; ENSGT00940000162521; -.
DR HOGENOM; CLU_021316_5_0_1; -.
DR InParanoid; Q49AG3; -.
DR OMA; FCTTNTL; -.
DR OrthoDB; 875619at2759; -.
DR PhylomeDB; Q49AG3; -.
DR TreeFam; TF328297; -.
DR PathwayCommons; Q49AG3; -.
DR SignaLink; Q49AG3; -.
DR BioGRID-ORCS; 58486; 3 hits in 235 CRISPR screens.
DR ChiTaRS; ZBED5; human.
DR GenomeRNAi; 58486; -.
DR Pharos; Q49AG3; Tdark.
DR PRO; PR:Q49AG3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q49AG3; protein.
DR Bgee; ENSG00000236287; Expressed in tibia and 201 other tissues.
DR ExpressionAtlas; Q49AG3; baseline and differential.
DR Genevisible; Q49AG3; HS.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50808; ZF_BED; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..693
FT /note="Zinc finger BED domain-containing protein 5"
FT /id="PRO_0000291958"
FT ZN_FING 108..164
FT /note="BED-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 132
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 135
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 152
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT BINDING 157
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT VARIANT 17
FT /note="A -> V (in dbSNP:rs2232918)"
FT /id="VAR_032895"
FT VARIANT 47
FT /note="Q -> R (in dbSNP:rs2232919)"
FT /id="VAR_032896"
FT VARIANT 77
FT /note="P -> S (in dbSNP:rs2232920)"
FT /id="VAR_032897"
FT VARIANT 480
FT /note="I -> V (in dbSNP:rs1046297)"
FT /evidence="ECO:0000269|PubMed:10607616"
FT /id="VAR_059741"
SQ SEQUENCE 693 AA; 78911 MW; EB69E97C9137FFB2 CRC64;
MIAPLLCILS YNFNTFAILN VYSKLTMFCT TNSLPMDLLL KQGSLKQEVE SFCYQIVSES
NDQKVGILQS EDKQLQPSVS KKSEGELSRV KFISNSNKIT FSKKPKRRKY DESYLSFGFT
YFGNRDAPHA QCVLCKKILS NSSLAPSKLR RHLETKHAAY KDKDISFFKQ HLDSPENNKP
PTPKIVNTDN ESATEASYNV SYHIALSGEA HTIGELLIKP CAKDVVMRMF DEQYSKKIDA
VQLSNSTVAR RIKDLAADIE EELVCRLKIC DGFSLQLDES ADVSGLAVLL VFVRYRFNKS
IEEDLLLCES LQSNATGEEI FNCINSFMQK HEIEWEKCVD VCSDASRAVD GKIAEAVTLI
KYVAPESTSS HCLLYRHALA VKIMPTSLKN VLDQAVQIIN YIKARPHQSR LLKILCEEMG
AQHTALLLNT EVRWLSRGKV LVRLFELRRE LLVFMDSAFR LSDCLTNSSW LLRLAYLADI
FTKLNEVNLS MQGKNVTVFT VFDKMSSLLR KLEFWASSVE EENFDCFPTL SDFLTEINST
VDKDICSAIV QHLRGLRATL LKYFPVTNDN NAWVRNPFTV TVKPASLVAR DYESLIDLTS
DSQVKQNFSE LSLNDFWSSL IQEYPSIARR AVRVLLPFAT MHLCETGFSY YAATKTKYRK
RLDAAPHMRI RLSNITPNIK RICDKKTQKH CSH
