ID   ZBED8_HUMAN             Reviewed;         594 AA.
AC   Q8IZ13; D3DQJ9; Q9H5S8; Q9UH87;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Protein ZBED8;
DE   AltName: Full=Transposon-derived Buster3 transposase-like protein;
DE   AltName: Full=Zinc finger BED domain-containing protein 8;
GN   Name=ZBED8; Synonyms=Buster3, C5orf54;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10607616; DOI=10.1016/s0959-437x(99)00031-3;
RA   Smit A.F.A.;
RT   "Interspersed repeats and other mementos of transposable elements in
RT   mammalian genomes.";
RL   Curr. Opin. Genet. Dev. 9:657-663(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Leiomyosarcoma, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   EVOLUTIONARY RELATIONSHIP WITH ZBED6, AND MISCELLANEOUS.
RX   PubMed=23533661; DOI=10.1371/journal.pone.0059940;
RA   Hayward A., Ghazal A., Andersson G., Andersson L., Jern P.;
RT   "ZBED evolution: repeated utilization of DNA transposons as regulators of
RT   diverse host functions.";
RL   PLoS ONE 8:E59940-E59940(2013).
CC   -!- INTERACTION:
CC       Q8IZ13; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-7186123, EBI-742054;
CC       Q8IZ13; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-7186123, EBI-16439278;
CC       Q8IZ13; Q8WXB1: METTL21A; NbExp=8; IntAct=EBI-7186123, EBI-8652459;
CC       Q8IZ13; Q15742: NAB2; NbExp=7; IntAct=EBI-7186123, EBI-8641936;
CC       Q8IZ13; Q04864-2: REL; NbExp=3; IntAct=EBI-7186123, EBI-10829018;
CC   -!- MISCELLANEOUS: May be derived from an ancient transposon that has lost
CC       its ability to translocate. Exhibits a close evolutionary relationship
CC       with ZBED5, but does not contain any zinc finger.
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DR   EMBL; AF205598; AAF18452.1; -; Genomic_DNA.
DR   EMBL; AK026754; BAB15542.1; -; mRNA.
DR   EMBL; CH471062; EAW61557.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61558.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61559.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61560.1; -; Genomic_DNA.
DR   EMBL; BC032603; AAH32603.1; -; mRNA.
DR   EMBL; BC112128; AAI12129.1; -; mRNA.
DR   EMBL; BC112130; AAI12131.1; -; mRNA.
DR   CCDS; CCDS34283.1; -.
DR   RefSeq; NP_001290180.1; NM_001303251.1.
DR   RefSeq; NP_071373.2; NM_022090.4.
DR   AlphaFoldDB; Q8IZ13; -.
DR   BioGRID; 121989; 17.
DR   IntAct; Q8IZ13; 15.
DR   MINT; Q8IZ13; -.
DR   STRING; 9606.ENSP00000386184; -.
DR   iPTMnet; Q8IZ13; -.
DR   PhosphoSitePlus; Q8IZ13; -.
DR   BioMuta; ZBED8; -.
DR   DMDM; 74728411; -.
DR   EPD; Q8IZ13; -.
DR   jPOST; Q8IZ13; -.
DR   MassIVE; Q8IZ13; -.
DR   MaxQB; Q8IZ13; -.
DR   PaxDb; Q8IZ13; -.
DR   PeptideAtlas; Q8IZ13; -.
DR   PRIDE; Q8IZ13; -.
DR   ProteomicsDB; 71267; -.
DR   Antibodypedia; 45858; 36 antibodies from 12 providers.
DR   DNASU; 63920; -.
DR   Ensembl; ENST00000408953.4; ENSP00000386184.3; ENSG00000221886.4.
DR   Ensembl; ENST00000523213.1; ENSP00000428831.1; ENSG00000221886.4.
DR   GeneID; 63920; -.
DR   KEGG; hsa:63920; -.
DR   MANE-Select; ENST00000408953.4; ENSP00000386184.3; NM_022090.5; NP_071373.2.
DR   UCSC; uc003lye.2; human.
DR   CTD; 63920; -.
DR   DisGeNET; 63920; -.
DR   GeneCards; ZBED8; -.
DR   HGNC; HGNC:30804; ZBED8.
DR   HPA; ENSG00000221886; Low tissue specificity.
DR   MIM; 615253; gene.
DR   neXtProt; NX_Q8IZ13; -.
DR   OpenTargets; ENSG00000221886; -.
DR   PharmGKB; PA164717348; -.
DR   VEuPathDB; HostDB:ENSG00000221886; -.
DR   eggNOG; ENOG502QT83; Eukaryota.
DR   GeneTree; ENSGT00940000163112; -.
DR   HOGENOM; CLU_021316_5_0_1; -.
DR   InParanoid; Q8IZ13; -.
DR   OMA; DDGYLMK; -.
DR   OrthoDB; 875619at2759; -.
DR   PhylomeDB; Q8IZ13; -.
DR   TreeFam; TF328297; -.
DR   PathwayCommons; Q8IZ13; -.
DR   SignaLink; Q8IZ13; -.
DR   BioGRID-ORCS; 63920; 11 hits in 1065 CRISPR screens.
DR   ChiTaRS; ZBED8; human.
DR   GenomeRNAi; 63920; -.
DR   Pharos; Q8IZ13; Tdark.
DR   PRO; PR:Q8IZ13; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q8IZ13; protein.
DR   Bgee; ENSG00000221886; Expressed in ventricular zone and 154 other tissues.
DR   Genevisible; Q8IZ13; HS.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   Pfam; PF14291; DUF4371; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..594
FT                   /note="Protein ZBED8"
FT                   /id="PRO_0000348452"
FT   VARIANT         523
FT                   /note="A -> S (in dbSNP:rs10515808)"
FT                   /id="VAR_046179"
FT   CONFLICT        63
FT                   /note="L -> F (in Ref. 1; AAF18452)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        556
FT                   /note="T -> P (in Ref. 2; BAB15542)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        584
FT                   /note="E -> D (in Ref. 2; BAB15542)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   594 AA;  68327 MW;  C786B19C80B75263 CRC64;
     MSKKRKWDDD YVRYWFTCTT EVDGTQRPQC VLCNSVFSNA DLRPSKLSDH FNRQHGGVAG
     HDLNSLKHMP APSDQSETLK AFGVASHEDT LLQASYQFAY LCAKEKNPHT VAEKLVKPCA
     LEIAQIVLGP DAQKKLQQVP LSDDVIHSRI DEMSQDILQQ VLEDIKASPL KVGIQLAETT
     DMDDCSQLMA FVRYIKEREI VEEFLFCEPL QLSMKGIDVF NLFRDFFLKH KIALDVCGSV
     CTDGASSMLG ENSEFVAYVK KEIPHIVVTH CLLNPHALVI KTLPTKLRDA LFTVVRVINF
     IKGRAPNHRL FQAFFEEIGI EYSVLLFHTE MRWLSRGQIL THIFEMYEEI NQFLHHKSSN
     LVDGFENKEF KIHLAYLADL FKHLNELSAS MQRTGMNTVS AREKLSAFVR KFPFWQKRIE
     KRNFTNFPFL EEIIVSDNEG IFIAAEITLH LQQLSNFFHG YFSIGDLNEA SKWILDPFLF
     NIDFVDDSYL MKNDLAELRA SGQILMEFET MKLEDFWCAQ FTAFPNLAKT ALEILMPFAT
     TYLCELGFSS LLHFKTKSRS CFNLSDDIRV AISKKVPRFS DIIEQKLQLQ QKSL