ID   ZBT18_XENLA             Reviewed;         520 AA.
AC   Q801P1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 18;
DE   AltName: Full=Zinc finger protein 238;
GN   Name=zbtb18; Synonyms=znf238;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a role in various
CC       developmental processes. Specifically binds the consensus DNA sequence
CC       5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by
CC       recruiting chromatin remodeling multiprotein complexes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZBTB18 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH48019.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC048019; AAH48019.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001080059.1; NM_001086590.1.
DR   RefSeq; XP_018117129.1; XM_018261640.1.
DR   AlphaFoldDB; Q801P1; -.
DR   SMR; Q801P1; -.
DR   DNASU; 379751; -.
DR   GeneID; 379751; -.
DR   KEGG; xla:379751; -.
DR   CTD; 379751; -.
DR   Xenbase; XB-GENE-1003548; zbtb18.L.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 379751; Expressed in brain and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..520
FT                   /note="Zinc finger and BTB domain-containing protein 18"
FT                   /id="PRO_0000391926"
FT   DOMAIN          24..91
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         408..430
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         436..458
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         464..487
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          121..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..137
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  58570 MW;  40DDBAB9A14F127E CRC64;
     MEFPEHSRHL LQCLSEQRHQ GFLCDCTVLV GDAHFRAHRA VLASCSMYFH LFYKDQLDKR
     DIVHLNSDIV TAPAFALLLE FMYEGILQFK GLPIEDVLAA ASYLHMYDIV KVCKKKLKEK
     ATTDSTKKEE DTSSFSDKVE CLSDGSSHMA GDLPSDEDDV EDEKINILPG KTDLATESRN
     MWIRLPTESA SIPRTVGEAE THTTAAGKTA VSPCSSTGSL SHRSAISMGD SADVDCVLDL
     SVKSSLSGTE TMNNSYLSSQ EILRNSLVQV KVEKEATCDK NDIDTTEYDI ERNTVKESVS
     SNIRASYEPV HLAPIREDSV LRELDHDDKA SDDDMITLEN ERVQMEANTD NSLLPYVPNI
     ISPTGQIFMC PLCNKVFPSP HILQIHLSTH FREQEGIRSK PANDVHVPTC SLCGKTFSCM
     YTLKRHERTH SGEKPYTCTQ CGKSFQYSHN LSRHAVVHTR EKPHACKWCE RRFTQSGDLY
     RHIRKFHCEL VNSLSVKSET LGLPAVRDWT LEDSSQELWK