ID   ZBT18_XENTR             Reviewed;         521 AA.
AC   Q0IJ29; Q28FU6;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 18;
DE   AltName: Full=Zinc finger protein 238;
GN   Name=zbtb18; Synonyms=znf238; ORFNames=TGas069c09.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-316.
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a role in various
CC       developmental processes. Specifically binds the consensus DNA sequence
CC       5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by
CC       recruiting chromatin remodeling multiprotein complexes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZBTB18 subfamily. {ECO:0000305}.
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DR   EMBL; BC121215; AAI21216.1; -; mRNA.
DR   EMBL; CR761742; CAJ83468.1; -; mRNA.
DR   RefSeq; NP_001016948.2; NM_001016948.3.
DR   AlphaFoldDB; Q0IJ29; -.
DR   SMR; Q0IJ29; -.
DR   STRING; 8364.ENSXETP00000031817; -.
DR   PaxDb; Q0IJ29; -.
DR   GeneID; 549702; -.
DR   KEGG; xtr:549702; -.
DR   CTD; 10472; -.
DR   Xenbase; XB-GENE-1003542; zbtb18.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_034521_0_0_1; -.
DR   InParanoid; Q0IJ29; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..521
FT                   /note="Zinc finger and BTB domain-containing protein 18"
FT                   /id="PRO_0000391929"
FT   DOMAIN          24..91
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         409..431
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         437..459
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         465..488
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          190..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        316
FT                   /note="P -> I (in Ref. 2; CAJ83468)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   521 AA;  58450 MW;  ECC5C9EDC63B24F2 CRC64;
     MEFPEHSRHL LQCLSEQRHQ GFLCDCTVLV GDAHFRAHRA VLASCSMYFH LFYKDQLDKR
     DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA ASYLHMYDIV KVCKKKLKEK
     ATTEADSTKK EEDASSCSDK IECLSDGSSH MAGDLPSDED DVEEEKINIL PGKTDLATES
     GNMWIRLPSD SASIPQTGGE AETHTAAAGK TADSPCSSTG SLSHRSATSM RDSADVDCVL
     DLSVKSSLSG AETLNNSYLS SQEILRNSLV QVKVEKEASC DENDIDTTEY DIERNTVKES
     SSSNIRAPYE PVHLAPIRED SVLRELDHDD KASDDDITPE NERVQMETNM DSSLLPYVPN
     ILSPAGQIFM CPLCNKVFPS PHILQIHLST HFREQEGIRS KPANDVHVPT CSLCGKTFSC
     MYTLKRHERT HSGEKPFTCT QCGKSFQYSH NLSRHAVVHT REKPHACKWC ERRFTQSGDL
     YRHIRKFHCE LVNSLSVKSE TLGLPAVRDW TLEDSSQELW K