ID   ZBT22_CANLF             Reviewed;         640 AA.
AC   Q5TJE2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 22;
DE   AltName: Full=Zinc finger protein 297;
GN   Name=ZBTB22; Synonyms=ZNF297;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Doberman pinscher;
RX   PubMed=15607421; DOI=10.1016/j.ygeno.2004.09.009;
RA   Debenham S.L., Hart E.A., Ashurst J.L., Howe K.L., Quail M.A.,
RA   Ollier W.E.R., Binns M.M.;
RT   "Genomic sequence of the class II region of the canine MHC: comparison with
RT   the MHC of other mammalian species.";
RL   Genomics 85:48-59(2005).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ630366; CAI11446.1; -; Genomic_DNA.
DR   RefSeq; XP_005627257.1; XM_005627200.2.
DR   AlphaFoldDB; Q5TJE2; -.
DR   SMR; Q5TJE2; -.
DR   STRING; 9612.ENSCAFP00000001388; -.
DR   PaxDb; Q5TJE2; -.
DR   Ensembl; ENSCAFT00000001511; ENSCAFP00000001388; ENSCAFG00000000977.
DR   Ensembl; ENSCAFT00030023311; ENSCAFP00030020325; ENSCAFG00030012594.
DR   Ensembl; ENSCAFT00040039520; ENSCAFP00040034480; ENSCAFG00040021306.
DR   Ensembl; ENSCAFT00845037986; ENSCAFP00845029765; ENSCAFG00845021534.
DR   GeneID; 607900; -.
DR   KEGG; cfa:607900; -.
DR   CTD; 9278; -.
DR   VEuPathDB; HostDB:ENSCAFG00845021534; -.
DR   VGNC; VGNC:48527; ZBTB22.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000160991; -.
DR   InParanoid; Q5TJE2; -.
DR   Proteomes; UP000002254; Chromosome 12.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR029833; ZBT22.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24414:SF4; PTHR24414:SF4; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..640
FT                   /note="Zinc finger and BTB domain-containing protein 22"
FT                   /id="PRO_0000047516"
FT   DOMAIN          57..121
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         490..511
FT                   /note="C2H2-type 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         517..539
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         545..571
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          191..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          332..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         203
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O15209"
SQ   SEQUENCE   640 AA;  65998 MW;  2495A2A4C851E607 CRC64;
     MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
     IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
     AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTTIT PAAATSATVP GAGVPSGSGA
     TVVPATVGSV RSHASSRASE NQSPSSSNYF SPRESTDFSS SSQEAFPASA VGSGERRGGG
     PVFPAPVVGS GGATSGKLLL EADELCHDGG DERGPVVPGA GLRRPTYAPP SIMPQKHWVY
     VKRGGNSPAP APLVPQDPDL EEDEEEDLVL TCEDDEDEEL GGGSRVPEAG GREATLSISD
     VRTLTEPPDK GEEQVNFCES SNDFGSYDGG GPGAGLDDSG GPTPSSYAPS HPPRPLLPLD
     MQGNQILVFP SSSSSSSSSS SSQAPGQPPG NQAEHGAVTL GGTSSGALGM PGGPGGTPGG
     TGSGDGNKIF LCHCGKAFSH KSMRDRHVNM HLNLRPFDCP VCNKKFKMKH HLTEHMKTHT
     GLKPYECGVC AKKFMWRDSF MRHRGHCERR HRLVGGGGGG GPGPGGPTGP TLPLKRESPG
     AGGGSGDEAS GATPQSSRRV WSPPSVHKVE MGFGGGGGTN