ZBT22_HUMAN
ID ZBT22_HUMAN Reviewed; 634 AA.
AC O15209; B0V007; Q5HYV4; Q5STL0; Q5STR7; Q8WV82;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 191.
DE RecName: Full=Zinc finger and BTB domain-containing protein 22;
DE AltName: Full=Protein BING1;
DE AltName: Full=Zinc finger and BTB domain-containing protein 22A;
DE AltName: Full=Zinc finger protein 297;
GN Name=ZBTB22; Synonyms=BING1, ZBTB22A, ZNF297;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9545376; DOI=10.1006/jmbi.1998.1637;
RA Herberg J.A., Beck S., Trowsdale J.;
RT "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense
RT cluster at the centromeric end of the MHC.";
RL J. Mol. Biol. 277:839-857(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-310.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-310.
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O15209; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-723574, EBI-10961312;
CC O15209; P51116: FXR2; NbExp=3; IntAct=EBI-723574, EBI-740459;
CC O15209; Q9H0R8: GABARAPL1; NbExp=4; IntAct=EBI-723574, EBI-746969;
CC O15209; O95995: GAS8; NbExp=3; IntAct=EBI-723574, EBI-1052570;
CC O15209; Q96EZ8: MCRS1; NbExp=6; IntAct=EBI-723574, EBI-348259;
CC O15209; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-723574, EBI-1104564;
CC O15209; Q6P2C6: MLLT6; NbExp=3; IntAct=EBI-723574, EBI-5773143;
CC O15209; Q13526: PIN1; NbExp=3; IntAct=EBI-723574, EBI-714158;
CC O15209; Q14498-3: RBM39; NbExp=3; IntAct=EBI-723574, EBI-6654703;
CC O15209; Q15560: TCEA2; NbExp=3; IntAct=EBI-723574, EBI-710310;
CC O15209; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-723574, EBI-1059156;
CC O15209; O95292: VAPB; NbExp=3; IntAct=EBI-723574, EBI-1188298;
CC O15209; A8KA83; NbExp=3; IntAct=EBI-723574, EBI-10174961;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; Z97183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z97184; CAB09990.1; -; Genomic_DNA.
DR EMBL; AK315747; BAG38101.1; -; mRNA.
DR EMBL; AL662820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03721.1; -; Genomic_DNA.
DR EMBL; BC018541; AAH18541.1; -; mRNA.
DR CCDS; CCDS4775.1; -.
DR RefSeq; NP_001138810.1; NM_001145338.1.
DR RefSeq; NP_005444.4; NM_005453.4.
DR AlphaFoldDB; O15209; -.
DR SMR; O15209; -.
DR BioGRID; 114695; 19.
DR DIP; DIP-62047N; -.
DR IntAct; O15209; 18.
DR STRING; 9606.ENSP00000407545; -.
DR iPTMnet; O15209; -.
DR PhosphoSitePlus; O15209; -.
DR BioMuta; ZBTB22; -.
DR EPD; O15209; -.
DR jPOST; O15209; -.
DR MassIVE; O15209; -.
DR MaxQB; O15209; -.
DR PaxDb; O15209; -.
DR PeptideAtlas; O15209; -.
DR PRIDE; O15209; -.
DR ProteomicsDB; 48510; -.
DR Antibodypedia; 29118; 116 antibodies from 22 providers.
DR DNASU; 9278; -.
DR Ensembl; ENST00000383196.4; ENSP00000372683.4; ENSG00000206280.7.
DR Ensembl; ENST00000416097.2; ENSP00000393514.2; ENSG00000229253.5.
DR Ensembl; ENST00000418540.2; ENSP00000388191.2; ENSG00000227780.5.
DR Ensembl; ENST00000418724.1; ENSP00000404403.1; ENSG00000236104.3.
DR Ensembl; ENST00000431845.3; ENSP00000407545.2; ENSG00000236104.3.
DR Ensembl; ENST00000445320.2; ENSP00000396292.2; ENSG00000237056.5.
DR GeneID; 9278; -.
DR KEGG; hsa:9278; -.
DR MANE-Select; ENST00000431845.3; ENSP00000407545.2; NM_005453.5; NP_005444.4.
DR UCSC; uc003oeb.4; human.
DR CTD; 9278; -.
DR DisGeNET; 9278; -.
DR GeneCards; ZBTB22; -.
DR HGNC; HGNC:13085; ZBTB22.
DR HPA; ENSG00000236104; Low tissue specificity.
DR MIM; 611439; gene.
DR neXtProt; NX_O15209; -.
DR OpenTargets; ENSG00000236104; -.
DR PharmGKB; PA37661; -.
DR VEuPathDB; HostDB:ENSG00000236104; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160991; -.
DR HOGENOM; CLU_029118_2_0_1; -.
DR InParanoid; O15209; -.
DR OMA; NRRVWSP; -.
DR OrthoDB; 830409at2759; -.
DR PhylomeDB; O15209; -.
DR PathwayCommons; O15209; -.
DR SignaLink; O15209; -.
DR BioGRID-ORCS; 9278; 8 hits in 1114 CRISPR screens.
DR ChiTaRS; ZBTB22; human.
DR GenomeRNAi; 9278; -.
DR Pharos; O15209; Tbio.
DR PRO; PR:O15209; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O15209; protein.
DR Bgee; ENSG00000236104; Expressed in apex of heart and 95 other tissues.
DR ExpressionAtlas; O15209; baseline and differential.
DR Genevisible; O15209; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR029833; ZBT22.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24414:SF4; PTHR24414:SF4; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..634
FT /note="Zinc finger and BTB domain-containing protein 22"
FT /id="PRO_0000047517"
FT DOMAIN 57..121
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 486..507
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 541..562
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 167..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..340
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 250
FT /note="G -> A (in dbSNP:rs35663442)"
FT /id="VAR_057457"
FT VARIANT 310
FT /note="T -> A (in dbSNP:rs3130100)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_022702"
SQ SEQUENCE 634 AA; 65602 MW; 9CC1867213D6DEF7 CRC64;
MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT
VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP
VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV
KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD
VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD
MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG
DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP
YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG
DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN
