ZBT22_MOUSE
ID ZBT22_MOUSE Reviewed; 638 AA.
AC Q9Z0G7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger and BTB domain-containing protein 22;
DE AltName: Full=Protein BING1;
DE AltName: Full=Zinc finger protein 297;
GN Name=Zbtb22; Synonyms=Bing1, Zfp297, Znf297;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J.,
RA Lasky S., Hood L.;
RT "Sequence of the mouse major histocompatibility complex class II region.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Embryo, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF110520; AAC97972.1; -; Genomic_DNA.
DR EMBL; AF100956; AAC69892.1; -; Genomic_DNA.
DR EMBL; BC026964; AAH26964.1; -; mRNA.
DR EMBL; BC052154; AAH52154.1; -; mRNA.
DR CCDS; CCDS28634.1; -.
DR RefSeq; NP_065650.1; NM_020625.3.
DR AlphaFoldDB; Q9Z0G7; -.
DR SMR; Q9Z0G7; -.
DR BioGRID; 219885; 3.
DR IntAct; Q9Z0G7; 2.
DR STRING; 10090.ENSMUSP00000057466; -.
DR iPTMnet; Q9Z0G7; -.
DR PhosphoSitePlus; Q9Z0G7; -.
DR PaxDb; Q9Z0G7; -.
DR PRIDE; Q9Z0G7; -.
DR ProteomicsDB; 302102; -.
DR Antibodypedia; 29118; 116 antibodies from 22 providers.
DR DNASU; 81630; -.
DR Ensembl; ENSMUST00000053429; ENSMUSP00000057466; ENSMUSG00000051390.
DR GeneID; 81630; -.
DR KEGG; mmu:81630; -.
DR UCSC; uc008cac.1; mouse.
DR CTD; 9278; -.
DR MGI; MGI:1931870; Zbtb22.
DR VEuPathDB; HostDB:ENSMUSG00000051390; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160991; -.
DR HOGENOM; CLU_029118_2_0_1; -.
DR InParanoid; Q9Z0G7; -.
DR OMA; NRRVWSP; -.
DR OrthoDB; 830409at2759; -.
DR PhylomeDB; Q9Z0G7; -.
DR BioGRID-ORCS; 81630; 6 hits in 72 CRISPR screens.
DR ChiTaRS; Zbtb22; mouse.
DR PRO; PR:Q9Z0G7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9Z0G7; protein.
DR Bgee; ENSMUSG00000051390; Expressed in granulocyte and 75 other tissues.
DR ExpressionAtlas; Q9Z0G7; baseline and differential.
DR Genevisible; Q9Z0G7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR029833; ZBT22.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24414:SF4; PTHR24414:SF4; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..638
FT /note="Zinc finger and BTB domain-containing protein 22"
FT /id="PRO_0000047518"
FT DOMAIN 57..121
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 483..504
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..559
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 171..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 203
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15209"
SQ SEQUENCE 638 AA; 66029 MW; 40343A4C6CB5EF6C CRC64;
MEPSALSPSG ATLPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
AADIVNFLTV GSVLQMWHIV DKCTELLREG RSAATTTTVT TAAAPSVSVP CASVPSGNGG
TVAPATVGSV RSHTSSRASE NQSPSSSNYF SPRESTDFSS TSQDAFVASA AGSGNRRDGG
PVFPAPVVGS AGTTSGKLLL EADELCDDGG DGRGAVAPGA GLRRSNCMPA SAVPQKHWVY
VKQARNCPAP ASLVHQDPDL EDEEEEEDLV LTCEDDEDEE MGGGSGVPAG GEPEATLSIS
DVRTLTEPAD KGEEQVNFCE SSNDFGPYEG GGAGAGLDDP GGPTPSSYAL THPPRPLLPL
DVPGNQILVF PSSSSQAPGQ PPGNTAEHGA VTLGGTSAVG LGIPSGSGGA PGGTGNSDGN
KIFLCHCGKA FSHKSMRDRH VNMHLNLRPF DCPVCNKKFK MKHHLTEHMK THTGLKPYEC
SVCAKKFMWR DSFMRHRGHC ERRHRMGVGG VGSGPGPGPG PGTPSGPALQ PKRESSTVGG
GSGDEANSAT PPSHRRVWSP PSVHKVEMDF SGGGGAAH
