ZBT24_DANRE
ID ZBT24_DANRE Reviewed; 672 AA.
AC Q52KB5; B3DIU4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger and BTB domain-containing protein 24;
DE AltName: Full=Zinc finger protein 450;
GN Name=zbtb24; Synonyms=zfp450; ORFNames=zgc:194556;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA05218.1}
RP IDENTIFICATION.
RX PubMed=15526281; DOI=10.1002/jcb.20299;
RA Edgar A.J., Dover S.L., Lodrick M.N., McKay I.J., Hughes F.J., Turner W.;
RT "Bone morphogenetic protein-2 induces expression of murine zinc finger
RT transcription factor ZNF450.";
RL J. Cell. Biochem. 94:202-215(2005).
CC -!- FUNCTION: May be involved in BMP2-induced transcription.
CC {ECO:0000250|UniProtKB:Q80X44}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000255}.
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DR EMBL; BX936450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163252; AAI63252.1; -; mRNA.
DR EMBL; BK005157; DAA05218.1; -; mRNA.
DR AlphaFoldDB; Q52KB5; -.
DR SMR; Q52KB5; -.
DR STRING; 7955.ENSDARP00000099482; -.
DR PaxDb; Q52KB5; -.
DR ZFIN; ZDB-GENE-081022-123; zbtb24.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q52KB5; -.
DR PhylomeDB; Q52KB5; -.
DR TreeFam; TF332049; -.
DR PRO; PR:Q52KB5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..672
FT /note="Zinc finger and BTB domain-containing protein 24"
FT /id="PRO_0000047737"
FT DOMAIN 39..105
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DNA_BIND 140..152
FT /note="A.T hook 1"
FT /evidence="ECO:0000255"
FT DNA_BIND 223..235
FT /note="A.T hook 2"
FT /evidence="ECO:0000255"
FT ZN_FING 237..259
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 293..315
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 136..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 166
FT /note="T -> S (in Ref. 2; AAI63252)"
FT /evidence="ECO:0000305"
FT CONFLICT 475
FT /note="P -> PEQQ (in Ref. 2; AAI63252)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 672 AA; 75410 MW; 2C8F21121BF6FD1B CRC64;
MSALPPSSSS PAVLALHSAT HKDTILHKFD TLRRSELLCD ITLIVEDVHF KAHKALLAAS
SEYFSALFTA EEQVSQSLYK LDGMTANTFS SVLEFMYSAV VLVDESSSEQ LMEMARFLVI
PDLIKAHEDL QAVDEHMQVK RKRGRPKKNQ DLSQKENPES ELQAQTSSEI QEVNEEPASP
ATDGSDGEFN PREERRREGK RKIKQPIRLK GFRMDDLMEG KEPGKRGRRR KYPDTEARCE
ECGKVFKSHL FLKIHQRTHT GEKPFRCSVC GKEFTQKHTL LVHQRMHTGE KPYICTVCSK
ALSTKHSLLE HMNLHTENKL FTCEECGKSF SQQRQLKSHN RVHTGKGLPE CAECHHKFMD
AAQLKKHLRT HTGEKPFTCE ICGKCFTAKS TLQTHIRIHR GEKPYVCKVC DKTFSDPSAR
RRHEVSHTGK KTFSCSICKV SFARKDNLKA HIKTHNKENP PAQAESTDKP PQSAPEQQEQ
EQQQQQQTSG DKELHSILQL QPFQLPAHGE QEIQLLVTGE NLSLDQEQSI SIITSEDTEQ
SLALLTQPSG HVQNLAVVTP DGNAQIQTIS VLGGEVNGGD PEQMHVITLS KEAMEQLQVH
HGAPQQLQVI HQLSEEQTGP VAGIHISGQS GQAISISQTT EQIPSDQIQG QTFQIQAGTV
SYLYTTSMNP QN
