ZBT24_RAT
ID ZBT24_RAT Reviewed; 705 AA.
AC Q3B725;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger and BTB domain-containing protein 24;
DE AltName: Full=Bone morphogenetic protein-induced factor 1;
DE AltName: Full=Zinc finger protein 450;
GN Name=Zbtb24 {ECO:0000312|RGD:1306951};
GN Synonyms=Bif1 {ECO:0000250|UniProtKB:Q80X44},
GN Znf450 {ECO:0000303|PubMed:15526281};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15057822};
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA01248.1}
RP IDENTIFICATION.
RX PubMed=15526281; DOI=10.1002/jcb.20299;
RA Edgar A.J., Dover S.L., Lodrick M.N., McKay I.J., Hughes F.J., Turner W.;
RT "Bone morphogenetic protein-2 induces expression of murine zinc finger
RT transcription factor ZNF450.";
RL J. Cell. Biochem. 94:202-215(2005).
CC -!- FUNCTION: May be involved in BMP2-induced transcription.
CC {ECO:0000250|UniProtKB:Q80X44}.
CC -!- SUBUNIT: Interacts with MN1. {ECO:0000250|UniProtKB:O43167}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000255}.
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DR EMBL; AC129792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001278; DAA01248.1; -; mRNA.
DR RefSeq; NP_001092137.1; NM_001098667.1.
DR AlphaFoldDB; Q3B725; -.
DR SMR; Q3B725; -.
DR STRING; 10116.ENSRNOP00000054002; -.
DR PaxDb; Q3B725; -.
DR PRIDE; Q3B725; -.
DR GeneID; 365590; -.
DR KEGG; rno:365590; -.
DR CTD; 9841; -.
DR RGD; 1306951; Zbtb24.
DR VEuPathDB; HostDB:ENSRNOG00000000308; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_024445_0_0_1; -.
DR InParanoid; Q3B725; -.
DR OMA; QAEQMHV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3B725; -.
DR TreeFam; TF332049; -.
DR PRO; PR:Q3B725; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000308; Expressed in thymus and 19 other tissues.
DR Genevisible; Q3B725; RN.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..705
FT /note="Zinc finger and BTB domain-containing protein 24"
FT /id="PRO_0000047736"
FT DOMAIN 37..103
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DNA_BIND 159..171
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT ZN_FING 293..315
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..483
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 489..511
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 151..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 78207 MW; 29562DF811332BF0 CRC64;
MADTTPEPSG HLIVHSDTHS DTVLASLEDQ RKKGFLCDIT LIVENVHFRA HKALLAASSE
YFSMMFAEEG EIGQSIYMLE GMVADTFGIL LEFIYTGYLH ASEKMTEQIL ATAQFLKVYD
LVKAYTDFQN SHNSPKPPAL NCSGTPVVVI SNKKNDPLKR KRGRPRKTNS LQEGKSELAA
EGEVQLRVNN SVQNRQNFVF KEDSVRLNEQ TPKEKELEPA GEPGSVEEMP AEKDENSDPK
ARDGPGSQSR YSKRRTRRSV KLKDYKLSGD EDDQSTAKRA TCGRQKRSSA PEARCKDCDR
VFKYSHFLAI HQRRHTGERP FKCSECGKGF AQKHSLQVHT RMHTGERPYT CTVCSKALTT
KHSLLEHMSL HSGQKSFTCD QCGKYFSQKR QLKSHYRVHT GHSLPECNHC HRKFMDVSQL
KKHLRTHTGE KPFTCEICGK SFTAKSSLQT HIRIHRGEKP YSCSICGKCF SDSSAKRRHC
VLHTGKKPFS CPECSLQFAR LDNLKAHLKI HSKEKHASDS SSVSGSSADE VRNVLQLQPY
QLSASGEQEI QLLVTDSVHN INFMPTPSQG VSIVAAESSQ NMATDPAANI TLLTQQPEQL
QGLILSAQQE QTEHIQSLGM IGSQMDTSQT EPVHVITLSK ETLEHLHAHQ EQTSSSVPAA
DTGARASSPP STRPGAELTQ APLTVPLDPS PGATVGGVAL WAVLL
