ID   ZBT25_GORGO             Reviewed;         435 AA.
AC   A1YEX3;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 25;
GN   Name=ZBTB25;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; DQ976482; ABM46691.1; -; Genomic_DNA.
DR   RefSeq; XP_018865095.1; XM_019009550.1.
DR   RefSeq; XP_018865096.1; XM_019009551.1.
DR   AlphaFoldDB; A1YEX3; -.
DR   SMR; A1YEX3; -.
DR   STRING; 9593.ENSGGOP00000011572; -.
DR   Ensembl; ENSGGOT00000011907; ENSGGOP00000011572; ENSGGOG00000011867.
DR   GeneID; 101145173; -.
DR   KEGG; ggo:101145173; -.
DR   CTD; 7597; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000159887; -.
DR   HOGENOM; CLU_025271_0_0_1; -.
DR   InParanoid; A1YEX3; -.
DR   OMA; PDHSNRG; -.
DR   OrthoDB; 567120at2759; -.
DR   Proteomes; UP000001519; Chromosome 14.
DR   Bgee; ENSGGOG00000011867; Expressed in heart and 6 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..435
FT                   /note="Zinc finger and BTB domain-containing protein 25"
FT                   /id="PRO_0000285477"
FT   DOMAIN          1..107
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         238..260
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         349..371
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        142
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        148
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        198
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        204
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        303
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        330
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
FT   CROSSLNK        405
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P24278"
SQ   SEQUENCE   435 AA;  49004 MW;  BB939C92C15DD3B6 CRC64;
     MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC
     IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP
     ETVQSSNLYG IQISTTQKTV VKQGLEVKEA PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT
     ADQQRACPAT QALEEHQKPP VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSIKIHLC
     HYCGERFDSR SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF
     IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS CTICGHKFPR
     KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS DVSLKSSRLS QEHLDLPCAL
     ESELTQENVD TILVE