CC150_HUMAN
ID CC150_HUMAN Reviewed; 1101 AA.
AC Q8NCX0; Q6P5U6; Q6P663; Q8N8V5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Coiled-coil domain-containing protein 150;
GN Name=CCDC150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-888 (ISOFORM 2).
RC TISSUE=Kidney, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NCX0; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10269342, EBI-618309;
CC Q8NCX0; P37198: NUP62; NbExp=3; IntAct=EBI-10269342, EBI-347978;
CC Q8NCX0-3; Q96JC9: EAF1; NbExp=3; IntAct=EBI-12235840, EBI-769261;
CC Q8NCX0-3; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12235840, EBI-618309;
CC Q8NCX0-3; P61970: NUTF2; NbExp=3; IntAct=EBI-12235840, EBI-591778;
CC Q8NCX0-3; Q99633: PRPF18; NbExp=3; IntAct=EBI-12235840, EBI-2798416;
CC Q8NCX0-3; P28074: PSMB5; NbExp=3; IntAct=EBI-12235840, EBI-357828;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8NCX0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCX0-2; Sequence=VSP_032873, VSP_032874, VSP_032877,
CC VSP_032878;
CC Name=3;
CC IsoId=Q8NCX0-3; Sequence=VSP_032872, VSP_032877, VSP_032878;
CC Name=4;
CC IsoId=Q8NCX0-4; Sequence=VSP_032872, VSP_032875, VSP_032876;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH62658.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AK096130; BAC04706.1; -; mRNA.
DR EMBL; AL834537; CAD39193.1; -; mRNA.
DR EMBL; AC068544; AAY14905.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70131.1; -; Genomic_DNA.
DR EMBL; BC062449; AAH62449.1; -; mRNA.
DR EMBL; BC062658; AAH62658.1; ALT_SEQ; mRNA.
DR CCDS; CCDS46478.1; -. [Q8NCX0-1]
DR RefSeq; NP_001074008.1; NM_001080539.1. [Q8NCX0-1]
DR AlphaFoldDB; Q8NCX0; -.
DR SMR; Q8NCX0; -.
DR BioGRID; 129990; 11.
DR IntAct; Q8NCX0; 7.
DR STRING; 9606.ENSP00000373827; -.
DR CarbonylDB; Q8NCX0; -.
DR iPTMnet; Q8NCX0; -.
DR PhosphoSitePlus; Q8NCX0; -.
DR BioMuta; CCDC150; -.
DR DMDM; 182705170; -.
DR EPD; Q8NCX0; -.
DR jPOST; Q8NCX0; -.
DR MassIVE; Q8NCX0; -.
DR PaxDb; Q8NCX0; -.
DR PeptideAtlas; Q8NCX0; -.
DR PRIDE; Q8NCX0; -.
DR ProteomicsDB; 72962; -. [Q8NCX0-1]
DR ProteomicsDB; 72963; -. [Q8NCX0-2]
DR ProteomicsDB; 72964; -. [Q8NCX0-3]
DR ProteomicsDB; 72965; -. [Q8NCX0-4]
DR Antibodypedia; 67231; 33 antibodies from 9 providers.
DR DNASU; 284992; -.
DR Ensembl; ENST00000389175.9; ENSP00000373827.4; ENSG00000144395.18. [Q8NCX0-1]
DR Ensembl; ENST00000448409.5; ENSP00000413957.1; ENSG00000144395.18. [Q8NCX0-2]
DR GeneID; 284992; -.
DR KEGG; hsa:284992; -.
DR MANE-Select; ENST00000389175.9; ENSP00000373827.4; NM_001080539.2; NP_001074008.1.
DR UCSC; uc002utp.1; human. [Q8NCX0-1]
DR CTD; 284992; -.
DR GeneCards; CCDC150; -.
DR HGNC; HGNC:26834; CCDC150.
DR HPA; ENSG00000144395; Tissue enhanced (kidney, testis).
DR neXtProt; NX_Q8NCX0; -.
DR OpenTargets; ENSG00000144395; -.
DR PharmGKB; PA162381583; -.
DR VEuPathDB; HostDB:ENSG00000144395; -.
DR eggNOG; ENOG502QRGC; Eukaryota.
DR GeneTree; ENSGT00390000005285; -.
DR HOGENOM; CLU_004802_0_0_1; -.
DR InParanoid; Q8NCX0; -.
DR OMA; AQEKCNL; -.
DR OrthoDB; 624497at2759; -.
DR PhylomeDB; Q8NCX0; -.
DR TreeFam; TF338017; -.
DR PathwayCommons; Q8NCX0; -.
DR SignaLink; Q8NCX0; -.
DR BioGRID-ORCS; 284992; 9 hits in 1087 CRISPR screens.
DR ChiTaRS; CCDC150; human.
DR GenomeRNAi; 284992; -.
DR Pharos; Q8NCX0; Tdark.
DR PRO; PR:Q8NCX0; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NCX0; protein.
DR Bgee; ENSG00000144395; Expressed in buccal mucosa cell and 101 other tissues.
DR ExpressionAtlas; Q8NCX0; baseline and differential.
DR Genevisible; Q8NCX0; HS.
DR InterPro; IPR038807; CCDC150.
DR PANTHER; PTHR35352; PTHR35352; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1101
FT /note="Coiled-coil domain-containing protein 150"
FT /id="PRO_0000328984"
FT REGION 1055..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..299
FT /evidence="ECO:0000255"
FT COILED 398..680
FT /evidence="ECO:0000255"
FT COILED 712..940
FT /evidence="ECO:0000255"
FT COILED 970..1033
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..685
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_032872"
FT VAR_SEQ 1..513
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_032873"
FT VAR_SEQ 514..622
FT /note="QTLEEENKHLADQMASLELQQVTSDYHGLAQQKVEKITESKNKLAYENGKLQ
FT IKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRVHLQQADAHLKE
FT -> MPLRKRKSPERTASSKSPEISRSHVNSIKERTSSVGLPSVIPNSTRRVSFAPNLPS
FT MKTSQDIGDSRISLKTLLNAIKTMEGRLEGKIEILASRPLINDESPNFLKQDS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_032874"
FT VAR_SEQ 853
FT /note="L -> V (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032875"
FT VAR_SEQ 854..1101
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032876"
FT VAR_SEQ 918..930
FT /note="QIEKELKQMELIK -> VVWETSSHFLDTL (in isoform 2 and
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_032877"
FT VAR_SEQ 931..1101
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_032878"
FT VARIANT 156
FT /note="E -> K (in dbSNP:rs34133636)"
FT /id="VAR_042600"
FT CONFLICT 746
FT /note="M -> V (in Ref. 5; AAH62658)"
FT /evidence="ECO:0000305"
FT CONFLICT 841
FT /note="T -> A (in Ref. 5; AAH62658)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1101 AA; 128761 MW; 1D22BFF73725E588 CRC64;
MDCKVHMETT VSRPVLSPTH INATASETFT VLQQRMRIVE EQTSSLRDDL IMLDFGEKRG
YLEAPDCLED LDSQKVISPI QNEAICAGKT DILWKNCEFL VNRMCRLESL MQSLKMNIFR
LQTEKDLNPQ KTAFLKDRLN AIQEEHSKDL KLLHLEVMNL RQQLRAVKEE EDKAQDEVQR
LTATLKIASQ TKKNAAIIEE ELKTTKRKMN LKIQELRRQL AQEKYLRESL EKSASAMLLK
IQEMGSTVEV ERKQVHILQQ NCIALRDSIQ SAQELLAQEQ KKKEELEIAT SQLKSDLTSR
DDLISKLVEE NKNLQISFNK EHEENAYLRS EIMSLHEASE KAQVLNDQLT KKCSELSCML
QTVTMEKARI IADHQAILQV EQKMMTQTFQ EQNLLLDAAH ASITNELQTV QNEKTQLQAH
LDHLILEHNQ CIQKAQDAEK RTAVQKELLE STIARLRGEL EASMQEKKSL LEEKERFQRE
VNKTEKEIVQ ERCNLEKELA KNKVDINTLT HNLQTLEEEN KHLADQMASL ELQQVTSDYH
GLAQQKVEKI TESKNKLAYE NGKLQIKVKQ LEEQVQSFTD TSLQNDHLRK MNKYLQTKYA
QANSELSAKR VHLQQADAHL KEVKSILERS KEELSRTVKC RNAALKESQK LKEDLEAVED
RENKKVGNFQ RQLAEAKEDN CKVTIMLENV LASHSKMQGA LEKVQIELGR RDSEIAGLKK
ERDLNQQRVQ KLEAEVDQWQ ARMLVMEDQH NSEIESLQKA LGVAREDNRK LAMSLEQALQ
TNNHLQTKLD HIQEQLESKE LERQNLETFK DRMTEESKVE AELHAERIEA LRKQFQTERE
TTKKVAQREV AELKKALDEA NFRSVEVSRT NRELRQKLAE LEKILESNKE KIKNQKTQIK
LHLSAKANNA QNIERMKQIE KELKQMELIK DQYQKKNYEQ SLSIQRFVCE MTNLQKEMQM
LAKSQYDASV RNKQQELHLE AERKIRQELE NRCQELEETV RHLKKCKEAT ENTLKEASVE
SEQITANLEE AHRWFKHRFD GLQLELTKNR LQRPSGEDRW QEKDQDVKHD VMSNQSVLHR
WERKQNLRPM PKKYHSEVQR K
