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ZBT41_HUMAN
ID   ZBT41_HUMAN             Reviewed;         909 AA.
AC   Q5SVQ8; A2RUA8; Q6MZT8; Q6ZR25; Q7Z4T1; Q8IZ99;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 41;
GN   Name=ZBTB41; Synonyms=FRBZ1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain, and Placenta;
RA   Goudou D., Bitoun M., Rieger F., Perin J.-P., Alliel P.M.;
RT   "Structure, gene mapping, and expression of FRBZ1.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 743-909.
RC   TISSUE=Fetal kidney;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5SVQ8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5SVQ8-2; Sequence=VSP_023092, VSP_023093;
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DR   EMBL; AY163816; AAN71742.2; -; mRNA.
DR   EMBL; AY336933; AAP97434.1; -; mRNA.
DR   EMBL; AK128549; BAC87496.1; -; mRNA.
DR   EMBL; AL356315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL627208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC132818; AAI32819.1; -; mRNA.
DR   EMBL; BC136600; AAI36601.1; -; mRNA.
DR   EMBL; BX640886; CAE45940.1; -; mRNA.
DR   CCDS; CCDS30960.1; -. [Q5SVQ8-1]
DR   RefSeq; NP_919290.2; NM_194314.2. [Q5SVQ8-1]
DR   RefSeq; XP_016856694.1; XM_017001205.1. [Q5SVQ8-2]
DR   AlphaFoldDB; Q5SVQ8; -.
DR   SMR; Q5SVQ8; -.
DR   BioGRID; 131819; 16.
DR   IntAct; Q5SVQ8; 1.
DR   STRING; 9606.ENSP00000356375; -.
DR   iPTMnet; Q5SVQ8; -.
DR   PhosphoSitePlus; Q5SVQ8; -.
DR   BioMuta; ZBTB41; -.
DR   DMDM; 74756116; -.
DR   EPD; Q5SVQ8; -.
DR   jPOST; Q5SVQ8; -.
DR   MassIVE; Q5SVQ8; -.
DR   MaxQB; Q5SVQ8; -.
DR   PaxDb; Q5SVQ8; -.
DR   PeptideAtlas; Q5SVQ8; -.
DR   PRIDE; Q5SVQ8; -.
DR   ProteomicsDB; 63949; -. [Q5SVQ8-1]
DR   ProteomicsDB; 63950; -. [Q5SVQ8-2]
DR   ABCD; Q5SVQ8; 2 sequenced antibodies.
DR   Antibodypedia; 50783; 93 antibodies from 16 providers.
DR   DNASU; 360023; -.
DR   Ensembl; ENST00000367405.5; ENSP00000356375.3; ENSG00000177888.8. [Q5SVQ8-1]
DR   Ensembl; ENST00000467322.1; ENSP00000502173.1; ENSG00000177888.8. [Q5SVQ8-2]
DR   GeneID; 360023; -.
DR   KEGG; hsa:360023; -.
DR   MANE-Select; ENST00000367405.5; ENSP00000356375.3; NM_194314.3; NP_919290.2.
DR   UCSC; uc001gtx.2; human. [Q5SVQ8-1]
DR   CTD; 360023; -.
DR   DisGeNET; 360023; -.
DR   GeneCards; ZBTB41; -.
DR   HGNC; HGNC:24819; ZBTB41.
DR   HPA; ENSG00000177888; Low tissue specificity.
DR   neXtProt; NX_Q5SVQ8; -.
DR   OpenTargets; ENSG00000177888; -.
DR   PharmGKB; PA142670545; -.
DR   VEuPathDB; HostDB:ENSG00000177888; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00550000075080; -.
DR   HOGENOM; CLU_014920_0_0_1; -.
DR   InParanoid; Q5SVQ8; -.
DR   OMA; RSFCYKK; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q5SVQ8; -.
DR   TreeFam; TF350933; -.
DR   PathwayCommons; Q5SVQ8; -.
DR   SignaLink; Q5SVQ8; -.
DR   BioGRID-ORCS; 360023; 37 hits in 1138 CRISPR screens.
DR   ChiTaRS; ZBTB41; human.
DR   GenomeRNAi; 360023; -.
DR   Pharos; Q5SVQ8; Tdark.
DR   PRO; PR:Q5SVQ8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q5SVQ8; protein.
DR   Bgee; ENSG00000177888; Expressed in endothelial cell and 180 other tissues.
DR   Genevisible; Q5SVQ8; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..909
FT                   /note="Zinc finger and BTB domain-containing protein 41"
FT                   /id="PRO_0000277814"
FT   DOMAIN          88..152
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         207..230
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         361..383
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         389..411
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         422..445
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         463..485
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         491..514
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         518..541
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         547..569
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         575..597
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         603..625
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         631..654
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         668..690
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         696..718
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         724..747
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          252..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..299
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..320
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..340
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         627
FT                   /note="G -> D (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_023092"
FT   VAR_SEQ         628..909
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_023093"
FT   VARIANT         327
FT                   /note="D -> Y (in dbSNP:rs10494751)"
FT                   /id="VAR_030601"
FT   CONFLICT        182
FT                   /note="F -> L (in Ref. 2; BAC87496)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   909 AA;  105192 MW;  BAB9F19F2F40772F CRC64;
     MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC YQELPPSPDQ
     RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS AHKVVVAVGS SYFHACLSKN
     PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV YKYEIPLVLE AAKFLDIIDA VKLLNNENVA
     PFHSELTEKS SPEETLNELT GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG
     LKMLERSFSA RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS
     EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP VVIQNSNKKI
     LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST KSNLTVHRKK HSNETEFHKK
     EHKCPYCNKL HASKKTLAKH VKRFHPENAQ EFISIKKTKS ESWKCDICKK SFTRRPHLEE
     HMILHSQDKP FKCTYCEEHF KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT
     HGGKRKWTCF ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD
     KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY KSVHLGEKVW
     QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI CNQSFRIKKT LTKHLVIHSD
     ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE
     TKQYMDQPKV YQSEAKTMLQ NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS
     PQPQSTDYPR AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ
     NISTNEHHS
 
 
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