ZBT41_MOUSE
ID ZBT41_MOUSE Reviewed; 908 AA.
AC Q811F1; A2A706; Q8BI96; Q8BV67; Q8BYV8;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 4.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger and BTB domain-containing protein 41;
GN Name=Zbtb41;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, Egg, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-907.
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC29469.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC37731.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAE37287.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK036544; BAC29469.1; ALT_FRAME; mRNA.
DR EMBL; AK037812; BAC29876.1; -; mRNA.
DR EMBL; AK079719; BAC37731.1; ALT_FRAME; mRNA.
DR EMBL; AK163302; BAE37287.1; ALT_INIT; mRNA.
DR EMBL; AL606536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046465; AAH46465.3; -; mRNA.
DR CCDS; CCDS48385.1; -.
DR RefSeq; NP_766231.2; NM_172643.5.
DR RefSeq; XP_006529509.1; XM_006529446.3.
DR RefSeq; XP_006529510.1; XM_006529447.3.
DR RefSeq; XP_006529511.1; XM_006529448.3.
DR AlphaFoldDB; Q811F1; -.
DR SMR; Q811F1; -.
DR BioGRID; 230517; 1.
DR STRING; 10090.ENSMUSP00000045570; -.
DR iPTMnet; Q811F1; -.
DR PhosphoSitePlus; Q811F1; -.
DR PaxDb; Q811F1; -.
DR PRIDE; Q811F1; -.
DR ProteomicsDB; 275055; -.
DR Antibodypedia; 50783; 93 antibodies from 16 providers.
DR Ensembl; ENSMUST00000039867; ENSMUSP00000045570; ENSMUSG00000033964.
DR GeneID; 226470; -.
DR KEGG; mmu:226470; -.
DR UCSC; uc007cwg.2; mouse.
DR CTD; 360023; -.
DR MGI; MGI:2444487; Zbtb41.
DR VEuPathDB; HostDB:ENSMUSG00000033964; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00550000075080; -.
DR InParanoid; Q811F1; -.
DR OMA; RSFCYKK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q811F1; -.
DR TreeFam; TF350933; -.
DR BioGRID-ORCS; 226470; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q811F1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q811F1; protein.
DR Bgee; ENSMUSG00000033964; Expressed in epithelium of lens and 217 other tissues.
DR ExpressionAtlas; Q811F1; baseline and differential.
DR Genevisible; Q811F1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..908
FT /note="Zinc finger and BTB domain-containing protein 41"
FT /id="PRO_0000277815"
FT DOMAIN 89..153
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 208..231
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..444
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 462..484
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 490..513
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 517..540
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 546..568
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 574..596
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 602..624
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 630..653
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 667..689
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 695..717
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 723..746
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 38..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..336
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 227..229
FT /note="LAK -> ASE (in Ref. 3; AAH46465)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="I -> V (in Ref. 3; AAH46465)"
FT /evidence="ECO:0000305"
FT CONFLICT 722
FT /note="P -> H (in Ref. 1; BAC37731)"
FT /evidence="ECO:0000305"
FT CONFLICT 896
FT /note="A -> T (in Ref. 3; AAH46465)"
FT /evidence="ECO:0000305"
FT CONFLICT 902
FT /note="C -> S (in Ref. 3; AAH46465)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 908 AA; 104683 MW; C7D50D9BB45FAC8C CRC64;
MKKRRKVTSN LDEKIHLGYH KDSSEENAAV ECGQVTYTQA PERPTPEAAQ RCQELPPSPD
QRKLLSSLQY NKNLLKYLND DRQKQPSFCD LLIIVEGKEF SAHKVVVAVG SSYFHACLSK
NPSTDVVTLD HVTHSVFQHL LEFLYTSEFF VYKYEIPLVL EAAKFLDIID AVKLLNNENV
AAFQAELTEK SSPEETLNEL TGRLSSSHQC KFCSRHFCYK KSLENHLAKT HRSLLLGKKH
GLKMLERSFS TRRSKRNRKC PVKFEDTSDD EQESGDGSDN LHQESSEKER SDRNDSEDPG
SEYNAEDEEL EEEVSDEDSD TEQSDKDNDA EEEPEAGDSA GSIHEGLAPV IIQNSNKKIL
QCPKCDKTFD RIGKYESHTR VHTGEKPFEC DICHQRYSTK SNLTVHRKKH SNEVEFHRKE
HKCPYCNKLH ASKKTLAKHV KRFHPENAQE FISIKKTKSE SWKCDICKKS FTRRPHLEEH
MILHSQDKPF KCTYCEEHFK SRFARLKHQE KFHLGPFPCD ICGRQFNDTG NLKRHIECTH
GGKRKWTCFI CGKSVRERTT LKEHLRIHSG EKPHLCSICG QSFRHGSSYR LHLRVHHDDK
RYECDECGKT FIRHDHLTKH KKIHSGEKAH QCEECGKCFG RRDHLTVHYK SVHLGEKVWQ
KYKATFHQCD VCKKIFKGKS SLEMHFRTHS GEKPYKCQIC NQSFRIKKTL TKHLVIHSDA
RPFNCQHCNA TFKRKDKLKY HIDHVHGIKS PDDSLSTSEE KLMSLPMEYS SDDKIFQAET
KQYLDQPKVY QSEAKTMLQN VSAEVCVPVT LVPVQMPDTS SDLVPHTTTL PTSSHEMLPP
QPQSTDYPRA ADLAFLEKYT LTPQPANIVH PVRPEQMLDP REPSYLGTLL GLDSTAAVQN
MCSSEHRS
