ZBT42_MOUSE
ID ZBT42_MOUSE Reviewed; 420 AA.
AC Q811H0;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Zinc finger and BTB domain-containing protein 42;
DE AltName: Full=Protein simiRP58;
GN Name=Zbtb42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, AND TISSUE SPECIFICITY.
RX PubMed=18262495; DOI=10.1016/j.bbrc.2008.01.147;
RA Takahashi A., Hirai S., Ohtaka-Maruyama C., Miwa A., Hata Y., Okabe S.,
RA Okado H.;
RT "Co-localization of a novel transcriptional repressor simiRP58 with RP58.";
RL Biochem. Biophys. Res. Commun. 368:637-642(2008).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21193930; DOI=10.1007/s00439-010-0940-2;
RA Devaney S.A., Mate S.E., Devaney J.M., Hoffman E.P.;
RT "Characterization of the ZBTB42 gene in humans and mice.";
RL Hum. Genet. 129:433-441(2011).
CC -!- FUNCTION: Transcriptional repressor. Specifically binds DNA and
CC probably acts by recruiting chromatin remodeling multiprotein
CC complexes. {ECO:0000269|PubMed:18262495}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18262495}. Nucleus,
CC nucleoplasm {ECO:0000269|PubMed:21193930}. Note=In skeletal myofibers,
CC highly enriched in subsynaptic nuclei at the neuromuscular junctions.
CC {ECO:0000269|PubMed:21193930}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q811H0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q811H0-2; Sequence=VSP_038770;
CC -!- TISSUE SPECIFICITY: Highly expressed in skeletal muscle and ovary (at
CC protein level). Low expression in brain, lung, spleen, liver and heart
CC (at protein level). Not detected in kidney and intestines (at protein
CC level). Also observed in testis and, at lower levels, in stomach and
CC nervous system. {ECO:0000269|PubMed:18262495,
CC ECO:0000269|PubMed:21193930}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZBTB18 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46387.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC124373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046387; AAH46387.1; ALT_INIT; mRNA.
DR CCDS; CCDS49190.1; -. [Q811H0-1]
DR RefSeq; NP_001093930.1; NM_001100460.1. [Q811H0-1]
DR AlphaFoldDB; Q811H0; -.
DR SMR; Q811H0; -.
DR STRING; 10090.ENSMUSP00000133152; -.
DR PhosphoSitePlus; Q811H0; -.
DR PaxDb; Q811H0; -.
DR PRIDE; Q811H0; -.
DR ProteomicsDB; 275127; -. [Q811H0-1]
DR ProteomicsDB; 275128; -. [Q811H0-2]
DR Antibodypedia; 58775; 72 antibodies from 11 providers.
DR Ensembl; ENSMUST00000169593; ENSMUSP00000133152; ENSMUSG00000037638. [Q811H0-1]
DR GeneID; 382639; -.
DR KEGG; mmu:382639; -.
DR UCSC; uc007pez.2; mouse. [Q811H0-2]
DR UCSC; uc007pfa.2; mouse. [Q811H0-1]
DR CTD; 100128927; -.
DR MGI; MGI:3644133; Zbtb42.
DR VEuPathDB; HostDB:ENSMUSG00000037638; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163959; -.
DR HOGENOM; CLU_034521_0_0_1; -.
DR InParanoid; Q811H0; -.
DR OMA; PCILQTP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q811H0; -.
DR TreeFam; TF337437; -.
DR BioGRID-ORCS; 382639; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Zbtb42; mouse.
DR PRO; PR:Q811H0; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q811H0; protein.
DR Bgee; ENSMUSG00000037638; Expressed in dorsal pancreas and 143 other tissues.
DR ExpressionAtlas; Q811H0; baseline and differential.
DR Genevisible; Q811H0; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..420
FT /note="Zinc finger and BTB domain-containing protein 42"
FT /id="PRO_0000391930"
FT DOMAIN 24..92
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 292..314
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..411
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 127..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..178
FT /note="MEFPEHGVRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLF
FT YRDQPASSRDTVRLNGDIVTVPAFSRLLDFMYEGRLDLHNLPVEDVLAAASYLHMYDIV
FT KVCKGRLRKKDPDLETRTLGTELPGQPPHPLPSWSPAFCQAAPKAKHPSLGVKATHPLP
FT TFGPPSWQ -> MTSSRSARADSERRTQIWRP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038770"
FT CONFLICT 197
FT /note="P -> R (in Ref. 2; AAH46387)"
FT /evidence="ECO:0000305"
FT CONFLICT 254
FT /note="G -> S (in Ref. 2; AAH46387)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="S -> T (in Ref. 2; AAH46387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 46717 MW; 885237984257BBC7 CRC64;
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDQPASS
RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HNLPVEDVLA AASYLHMYDI VKVCKGRLRK
KDPDLETRTL GTELPGQPPH PLPSWSPAFC QAAPKAKHPS LGVKATHPLP TFGPPSWQVA
EQSSGALDLS LKPSPRPEQV HPPCRLQTSL CSSVQQVAQP LVKAEQDSFS EQDSSSPQSA
DRSPPPVCAS AAQGLAVDLE PLHIEGTGSQ QLGLPAEPVL DSEELGPSRH LCICPLCCKL
FPSTHALQLH LSAHFRERDS VRARLSPEGS VPTCPLCSKT FSCTYTLKRH ERTHSGEKPY
TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS GDLYRHVRKF HYGLVKPLLV
