ID   ZBT42_RAT               Reviewed;         420 AA.
AC   B1WBS3;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 42;
GN   Name=Zbtb42;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional repressor. Specifically binds DNA and
CC       probably acts by recruiting chromatin remodeling multiprotein
CC       complexes. {ECO:0000250|UniProtKB:Q811H0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q811H0}.
CC       Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q811H0}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZBTB18 subfamily. {ECO:0000305}.
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DR   EMBL; BC161864; AAI61864.1; -; mRNA.
DR   RefSeq; NP_001119774.1; NM_001126302.1.
DR   AlphaFoldDB; B1WBS3; -.
DR   SMR; B1WBS3; -.
DR   STRING; 10116.ENSRNOP00000035859; -.
DR   PaxDb; B1WBS3; -.
DR   Ensembl; ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562.
DR   GeneID; 691556; -.
DR   KEGG; rno:691556; -.
DR   UCSC; RGD:1582758; rat.
DR   CTD; 100128927; -.
DR   RGD; 1582758; Zbtb42.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000163959; -.
DR   HOGENOM; CLU_034521_0_0_1; -.
DR   InParanoid; B1WBS3; -.
DR   OMA; PCILQTP; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; B1WBS3; -.
DR   TreeFam; TF337437; -.
DR   PRO; PR:B1WBS3; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000037562; Expressed in testis and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..420
FT                   /note="Zinc finger and BTB domain-containing protein 42"
FT                   /id="PRO_0000343712"
FT   DOMAIN          24..92
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         292..314
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         332..354
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         360..382
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         388..411
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          174..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   420 AA;  46628 MW;  4FFA4279B16B1EF5 CRC64;
     MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH LFYRDQPASS
     RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA AASYLHMYDI VKVCKGRLRK
     KDPDLETRTL GTELPGQTPH PLPSWPPAFC QATPKAKPPS LGVKAVHPLP KFGPPSWQVS
     EESSGALDLS LKPGPRPEQA HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA
     DRSPPPVCAS AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL
     FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH ERTHSGEKPY
     TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS GDLYRHVRKF HYGLVKPLLV