ZBT47_HUMAN
ID ZBT47_HUMAN Reviewed; 747 AA.
AC Q9UFB7; H7BXD3; Q6ZSY6; Q8WTY8; Q9ULN0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Zinc finger and BTB domain-containing protein 47;
DE AltName: Full=Zinc finger protein 651;
GN Name=ZBTB47; Synonyms=KIAA1190, ZNF651;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-747 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-747 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 574-747 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-190, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UFB7; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-7781767, EBI-739624;
CC Q9UFB7; Q92997: DVL3; NbExp=3; IntAct=EBI-7781767, EBI-739789;
CC Q9UFB7; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-7781767, EBI-746704;
CC Q9UFB7; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-7781767, EBI-10961706;
CC Q9UFB7; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-7781767, EBI-11522433;
CC Q9UFB7; Q9NZQ3-3: NCKIPSD; NbExp=3; IntAct=EBI-7781767, EBI-10963850;
CC Q9UFB7; Q9UL41: PNMA3; NbExp=3; IntAct=EBI-7781767, EBI-11278955;
CC Q9UFB7; Q08117-2: TLE5; NbExp=5; IntAct=EBI-7781767, EBI-11741437;
CC Q9UFB7; P17020: ZNF16; NbExp=3; IntAct=EBI-7781767, EBI-3921553;
CC Q9UFB7; Q53GI3: ZNF394; NbExp=3; IntAct=EBI-7781767, EBI-10211248;
CC Q9UFB7; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-7781767, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UFB7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UFB7-2; Sequence=VSP_054051;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21855.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB61386.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK127065; BAC86810.1; -; mRNA.
DR EMBL; AC006059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133062; CAB61386.2; ALT_INIT; mRNA.
DR EMBL; BC021855; AAH21855.1; ALT_INIT; mRNA.
DR EMBL; AB033016; BAA86504.1; -; mRNA.
DR CCDS; CCDS46805.2; -. [Q9UFB7-1]
DR PIR; T42663; T42663.
DR RefSeq; NP_660149.2; NM_145166.3. [Q9UFB7-1]
DR AlphaFoldDB; Q9UFB7; -.
DR SMR; Q9UFB7; -.
DR BioGRID; 124993; 299.
DR IntAct; Q9UFB7; 12.
DR MINT; Q9UFB7; -.
DR STRING; 9606.ENSP00000232974; -.
DR iPTMnet; Q9UFB7; -.
DR PhosphoSitePlus; Q9UFB7; -.
DR BioMuta; ZBTB47; -.
DR DMDM; 74761930; -.
DR jPOST; Q9UFB7; -.
DR MassIVE; Q9UFB7; -.
DR MaxQB; Q9UFB7; -.
DR PaxDb; Q9UFB7; -.
DR PeptideAtlas; Q9UFB7; -.
DR PRIDE; Q9UFB7; -.
DR ProteomicsDB; 43241; -.
DR ProteomicsDB; 84176; -. [Q9UFB7-1]
DR Antibodypedia; 29276; 79 antibodies from 15 providers.
DR DNASU; 92999; -.
DR Ensembl; ENST00000232974.11; ENSP00000232974.6; ENSG00000114853.15. [Q9UFB7-1]
DR GeneID; 92999; -.
DR KEGG; hsa:92999; -.
DR MANE-Select; ENST00000232974.11; ENSP00000232974.6; NM_145166.4; NP_660149.2.
DR UCSC; uc003clu.3; human. [Q9UFB7-1]
DR CTD; 92999; -.
DR GeneCards; ZBTB47; -.
DR HGNC; HGNC:26955; ZBTB47.
DR HPA; ENSG00000114853; Tissue enhanced (skeletal).
DR neXtProt; NX_Q9UFB7; -.
DR OpenTargets; ENSG00000114853; -.
DR PharmGKB; PA162409466; -.
DR VEuPathDB; HostDB:ENSG00000114853; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160089; -.
DR HOGENOM; CLU_002678_74_2_1; -.
DR InParanoid; Q9UFB7; -.
DR OMA; GTYGRQE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UFB7; -.
DR TreeFam; TF332655; -.
DR PathwayCommons; Q9UFB7; -.
DR SignaLink; Q9UFB7; -.
DR SIGNOR; Q9UFB7; -.
DR BioGRID-ORCS; 92999; 18 hits in 1126 CRISPR screens.
DR ChiTaRS; ZBTB47; human.
DR GenomeRNAi; 92999; -.
DR Pharos; Q9UFB7; Tdark.
DR PRO; PR:Q9UFB7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9UFB7; protein.
DR Bgee; ENSG00000114853; Expressed in left ventricle myocardium and 173 other tissues.
DR ExpressionAtlas; Q9UFB7; baseline and differential.
DR Genevisible; Q9UFB7; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..747
FT /note="Zinc finger and BTB domain-containing protein 47"
FT /id="PRO_0000251896"
FT DOMAIN 15..83
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 436..459
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 463..485
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 490..513
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 576..598
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 604..626
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 632..654
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 660..687
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 243..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..736
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 190
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 330..430
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054051"
FT VARIANT 385
FT /note="A -> T (in dbSNP:rs9878239)"
FT /id="VAR_027715"
FT CONFLICT 160
FT /note="P -> R (in Ref. 1; BAC86810)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="L -> P (in Ref. 1; BAC86810)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="D -> G (in Ref. 1; BAC86810)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="Missing (in Ref. 1; BAC86810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 747 AA; 82760 MW; 8F816B6B7BD4DFDE CRC64;
MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK QLQRVELSLE
ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD IAASCQELLD ARSLGPPGPG
TVALAQPAAS CTPAAPPYYC DIKQEADTPG LPKIYAREGP DPYSVRVEDG AGTAGGTVPA
TIGPAQPFFK EEKEGGVEEA GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL
NNQTLHVSTG PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR
EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG EEGEAGGKQG
PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG GKRPKPPPGV ASASARGPPA
TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY LEKHMNVTHS RMQICDQCGK RFLLESELLL
HRQTDCERNI QCVTCGKAFK KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV
AHTKDMPFTC ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG
HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH RRTHTGEKPY
PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL PPTQPQAHAL PLLPGLPQTL
PPPPHLPPPP PLFPTTASPG GRMNANN