ZBT7C_HUMAN
ID ZBT7C_HUMAN Reviewed; 619 AA.
AC A1YPR0; O73453;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc finger and BTB domain-containing protein 7C;
DE AltName: Full=Affected by papillomavirus DNA integration in ME180 cells protein 1;
DE Short=APM-1;
DE AltName: Full=Zinc finger and BTB domain-containing protein 36;
DE AltName: Full=Zinc finger protein 857C;
GN Name=ZBTB7C; Synonyms=APM1, ZBTB36, ZNF857C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9427755; DOI=10.1093/emboj/17.1.215;
RA Reuter S., Bartelmann M., Vogt M., Geisen C., Napierski I., Kahn T.,
RA Delius H., Lichter P., Weitz S., Korn B., Schwarz E.;
RT "APM-1, a novel human gene, identified by aberrant co-transcription with
RT papillomavirus oncogenes in a cervical carcinoma cell line, encodes a
RT BTB/POZ-zinc finger protein with growth inhibitory activity.";
RL EMBO J. 17:215-222(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gilling M., Ullmann R., Kristoffersson U., Moller M., Friis-Henriksen K.,
RA Bugge M., Tumer Z., Tommerup N.;
RT "ZBTB7C.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be a tumor suppressor gene. {ECO:0000269|PubMed:9427755}.
CC -!- TISSUE SPECIFICITY: Detected in normal cervical keratinocytes, and in
CC some cervical carcinoma cell lines. {ECO:0000269|PubMed:9427755}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y14591; CAA74933.1; -; mRNA.
DR EMBL; EF120357; ABL98073.1; -; mRNA.
DR CCDS; CCDS32830.1; -.
DR RefSeq; NP_001034449.1; NM_001039360.2.
DR RefSeq; NP_001305770.1; NM_001318841.1.
DR RefSeq; XP_005258286.1; XM_005258229.4.
DR RefSeq; XP_011524172.1; XM_011525870.2.
DR RefSeq; XP_011524173.1; XM_011525871.2.
DR RefSeq; XP_016881098.1; XM_017025609.1.
DR AlphaFoldDB; A1YPR0; -.
DR SMR; A1YPR0; -.
DR BioGRID; 128390; 29.
DR DIP; DIP-61583N; -.
DR IntAct; A1YPR0; 4.
DR MINT; A1YPR0; -.
DR STRING; 9606.ENSP00000468782; -.
DR iPTMnet; A1YPR0; -.
DR PhosphoSitePlus; A1YPR0; -.
DR BioMuta; ZBTB7C; -.
DR jPOST; A1YPR0; -.
DR MassIVE; A1YPR0; -.
DR PaxDb; A1YPR0; -.
DR PeptideAtlas; A1YPR0; -.
DR PRIDE; A1YPR0; -.
DR ProteomicsDB; 162; -.
DR Antibodypedia; 2877; 81 antibodies from 15 providers.
DR DNASU; 201501; -.
DR Ensembl; ENST00000535628.6; ENSP00000439781.1; ENSG00000184828.10.
DR Ensembl; ENST00000586438.5; ENSP00000468254.1; ENSG00000184828.10.
DR Ensembl; ENST00000588982.5; ENSP00000468782.1; ENSG00000184828.10.
DR Ensembl; ENST00000590800.6; ENSP00000467877.1; ENSG00000184828.10.
DR GeneID; 201501; -.
DR KEGG; hsa:201501; -.
DR MANE-Select; ENST00000590800.6; ENSP00000467877.1; NM_001318841.2; NP_001305770.1.
DR CTD; 201501; -.
DR DisGeNET; 201501; -.
DR GeneCards; ZBTB7C; -.
DR HGNC; HGNC:31700; ZBTB7C.
DR HPA; ENSG00000184828; Tissue enhanced (esophagus).
DR MIM; 616591; gene.
DR neXtProt; NX_A1YPR0; -.
DR OpenTargets; ENSG00000184828; -.
DR PharmGKB; PA134861865; -.
DR VEuPathDB; HostDB:ENSG00000184828; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159814; -.
DR HOGENOM; CLU_025627_2_0_1; -.
DR InParanoid; A1YPR0; -.
DR OMA; ENDYSAY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A1YPR0; -.
DR TreeFam; TF331824; -.
DR PathwayCommons; A1YPR0; -.
DR SignaLink; A1YPR0; -.
DR BioGRID-ORCS; 201501; 11 hits in 1132 CRISPR screens.
DR ChiTaRS; ZBTB7C; human.
DR GenomeRNAi; 201501; -.
DR Pharos; A1YPR0; Tbio.
DR PRO; PR:A1YPR0; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; A1YPR0; protein.
DR Bgee; ENSG00000184828; Expressed in mammalian vulva and 138 other tissues.
DR ExpressionAtlas; A1YPR0; baseline and differential.
DR Genevisible; A1YPR0; HS.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1903025; P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Tumor suppressor; Zinc;
KW Zinc-finger.
FT CHAIN 1..619
FT /note="Zinc finger and BTB domain-containing protein 7C"
FT /id="PRO_0000337869"
FT DOMAIN 34..101
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 364..386
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..478
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 129..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 69017 MW; 73D82A34502B55BF CRC64;
MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS VLAACSKYFK
KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT AGNVKHILNA ARMLEIQCIV
NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD EEDEEEEEEE EEDDDDDTED FADQENLPDP
QDISCHQSPS KTDHLTEKAY SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN
IPDRRPSLSP FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP
PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW PLVEERKLKP
KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR FTRQDKLKIH MRKHTGERPY
LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG
RKPAAWRAAS LLFGPGGPAP DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG
ALSLQELERQ FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA
GLPGLAGLNH VASMSEANN
