ZBT7C_MOUSE
ID ZBT7C_MOUSE Reviewed; 619 AA.
AC Q8VCZ7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger and BTB domain-containing protein 7C;
DE AltName: Full=Zinc finger and BTB domain-containing protein 36;
GN Name=Zbtb7c; Synonyms=Zbtb36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a tumor suppressor gene. {ECO:0000250}.
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DR EMBL; AK045522; BAC32405.1; -; mRNA.
DR EMBL; BC018187; AAH18187.1; -; mRNA.
DR EMBL; BC070424; AAH70424.1; -; mRNA.
DR CCDS; CCDS29349.1; -.
DR RefSeq; NP_663331.1; NM_145356.3.
DR RefSeq; XP_006525800.1; XM_006525737.3.
DR AlphaFoldDB; Q8VCZ7; -.
DR SMR; Q8VCZ7; -.
DR BioGRID; 228889; 7.
DR STRING; 10090.ENSMUSP00000057856; -.
DR iPTMnet; Q8VCZ7; -.
DR PhosphoSitePlus; Q8VCZ7; -.
DR PaxDb; Q8VCZ7; -.
DR PRIDE; Q8VCZ7; -.
DR ProteomicsDB; 275265; -.
DR Antibodypedia; 2877; 81 antibodies from 15 providers.
DR DNASU; 207259; -.
DR Ensembl; ENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646.
DR Ensembl; ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646.
DR Ensembl; ENSMUST00000236462; ENSMUSP00000157716; ENSMUSG00000044646.
DR GeneID; 207259; -.
DR KEGG; mmu:207259; -.
DR UCSC; uc008fqi.1; mouse.
DR CTD; 201501; -.
DR MGI; MGI:2443302; Zbtb7c.
DR VEuPathDB; HostDB:ENSMUSG00000044646; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159814; -.
DR HOGENOM; CLU_025627_2_0_1; -.
DR InParanoid; Q8VCZ7; -.
DR OMA; ENDYSAY; -.
DR OrthoDB; 268859at2759; -.
DR PhylomeDB; Q8VCZ7; -.
DR TreeFam; TF331824; -.
DR BioGRID-ORCS; 207259; 7 hits in 71 CRISPR screens.
DR ChiTaRS; Zbtb7c; mouse.
DR PRO; PR:Q8VCZ7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8VCZ7; protein.
DR Bgee; ENSMUSG00000044646; Expressed in glomerular capsule and 125 other tissues.
DR Genevisible; Q8VCZ7; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:1903025; P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Tumor suppressor; Zinc;
KW Zinc-finger.
FT CHAIN 1..619
FT /note="Zinc finger and BTB domain-containing protein 7C"
FT /id="PRO_0000337870"
FT DOMAIN 34..101
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 364..386
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..414
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 420..442
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 448..478
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 129..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 69086 MW; FC5E6A222BCB5460 CRC64;
MANDIDELIG IPFPNHSSEV LCSLNEQRHA GLLCDVLLVV QEQEYRTHRS VLAACSKYFK
KLFTAGSLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT ASNVKHILNA ARMLEIQCIV
NVCLEIMEPG GSVGEEDDKE EEDEDDDDED EDDEEEEEEE EEEEEDDPED FADQENLPDP
QDITCPQSPS KTDHLTEKDY SDTPRDFPDS FQPGSPGHLG VIRDFSIESL LRENLYPKAN
IPDRRPSLSP FAPEFFPHLW PGGFGAFAQL PEQPMDSGPL DLVIKNRKIK EEDKEELAPP
PPPPFSSDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGSLFPPW PLVEERKLKP
KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCSICEVR FTRQDKLKIH MRKHTGERPY
LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG
RKPAAWRAAS LLFGPGGPSA DKAAFVMPPA LGDVGGHLGG TAVCLPGPSP AKHFLASPKG
TLSLQELERQ FEETQMKLFG RAQLEAERNA GGLLALALAE NVAATRPYFP LPDPWAAGLA
GLPGLTGLNH VASMSEANN
