CC152_HUMAN
ID CC152_HUMAN Reviewed; 254 AA.
AC Q4G0S7; B3KXI4; B4E0P7; Q5BLP6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Coiled-coil domain-containing protein 152;
GN Name=CCDC152; ORFNames=Chr5_400;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Substantia nigra, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-61 (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=15809229; DOI=10.1093/nar/gki328;
RA Castelo R., Reymond A., Wyss C., Camara F., Parra G., Antonarakis S.E.,
RA Guigo R., Eyras E.;
RT "Comparative gene finding in chicken indicates that we are closing in on
RT the set of multi-exonic widely expressed human genes.";
RL Nucleic Acids Res. 33:1935-1939(2005).
CC -!- INTERACTION:
CC Q4G0S7; Q16543: CDC37; NbExp=3; IntAct=EBI-18398007, EBI-295634;
CC Q4G0S7; O95363: FARS2; NbExp=3; IntAct=EBI-18398007, EBI-2513774;
CC Q4G0S7; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-18398007, EBI-741158;
CC Q4G0S7; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-18398007, EBI-6116822;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4G0S7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4G0S7-2; Sequence=VSP_056904;
CC -!- TISSUE SPECIFICITY: Detected in stomach. {ECO:0000269|PubMed:15809229}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39102.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK127368; BAG54496.1; -; mRNA.
DR EMBL; AK303469; BAG64509.1; -; mRNA.
DR EMBL; AC008945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471119; EAW56024.1; -; Genomic_DNA.
DR EMBL; BC039102; AAH39102.1; ALT_INIT; mRNA.
DR EMBL; AY947526; AAX21787.1; -; mRNA.
DR CCDS; CCDS47203.1; -. [Q4G0S7-1]
DR RefSeq; NP_001128320.1; NM_001134848.1. [Q4G0S7-1]
DR AlphaFoldDB; Q4G0S7; -.
DR SMR; Q4G0S7; -.
DR BioGRID; 934298; 4.
DR IntAct; Q4G0S7; 4.
DR STRING; 9606.ENSP00000354888; -.
DR iPTMnet; Q4G0S7; -.
DR PhosphoSitePlus; Q4G0S7; -.
DR BioMuta; CCDC152; -.
DR DMDM; 296439416; -.
DR EPD; Q4G0S7; -.
DR jPOST; Q4G0S7; -.
DR MassIVE; Q4G0S7; -.
DR MaxQB; Q4G0S7; -.
DR PaxDb; Q4G0S7; -.
DR PeptideAtlas; Q4G0S7; -.
DR PRIDE; Q4G0S7; -.
DR ProteomicsDB; 5689; -.
DR ProteomicsDB; 62125; -. [Q4G0S7-1]
DR Antibodypedia; 49882; 18 antibodies from 8 providers.
DR DNASU; 100129792; -.
DR Ensembl; ENST00000361970.10; ENSP00000354888.5; ENSG00000198865.10. [Q4G0S7-1]
DR Ensembl; ENST00000388827.4; ENSP00000373479.4; ENSG00000198865.10. [Q4G0S7-2]
DR GeneID; 100129792; -.
DR KEGG; hsa:100129792; -.
DR MANE-Select; ENST00000361970.10; ENSP00000354888.5; NM_001134848.2; NP_001128320.1.
DR UCSC; uc003jmx.4; human. [Q4G0S7-1]
DR CTD; 100129792; -.
DR DisGeNET; 100129792; -.
DR GeneCards; CCDC152; -.
DR HGNC; HGNC:34438; CCDC152.
DR HPA; ENSG00000198865; Tissue enriched (liver).
DR neXtProt; NX_Q4G0S7; -.
DR OpenTargets; ENSG00000198865; -.
DR PharmGKB; PA162381615; -.
DR VEuPathDB; HostDB:ENSG00000198865; -.
DR eggNOG; ENOG502QRE3; Eukaryota.
DR GeneTree; ENSGT00390000010075; -.
DR HOGENOM; CLU_090538_1_0_1; -.
DR InParanoid; Q4G0S7; -.
DR OMA; MTKLNCV; -.
DR PhylomeDB; Q4G0S7; -.
DR TreeFam; TF350487; -.
DR PathwayCommons; Q4G0S7; -.
DR SignaLink; Q4G0S7; -.
DR BioGRID-ORCS; 100129792; 37 hits in 1066 CRISPR screens.
DR ChiTaRS; CCDC152; human.
DR GenomeRNAi; 100129792; -.
DR Pharos; Q4G0S7; Tdark.
DR PRO; PR:Q4G0S7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q4G0S7; protein.
DR Bgee; ENSG00000198865; Expressed in pancreatic ductal cell and 191 other tissues.
DR ExpressionAtlas; Q4G0S7; baseline and differential.
DR Genevisible; Q4G0S7; HS.
DR InterPro; IPR038827; CCDC152.
DR PANTHER; PTHR35253; PTHR35253; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..254
FT /note="Coiled-coil domain-containing protein 152"
FT /id="PRO_0000320586"
FT COILED 61..246
FT /evidence="ECO:0000255"
FT VAR_SEQ 87..142
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056904"
FT VARIANT 251
FT /note="R -> H (in dbSNP:rs6879044)"
FT /id="VAR_059596"
FT CONFLICT 173
FT /note="E -> V (in Ref. 4; AAH39102)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="Q -> K (in Ref. 4; AAH39102)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 254 AA; 29979 MW; 768B2D7F2550C774 CRC64;
MDQSSEGCMK KISSVNLDKL INDFSQIEKK MVETNGKNNI LDIQLEKSNC LLKVMQAKEV
SIKEECATLH NIIKGLQQTI EYQQNLKGEN EQLKISADLI KEKLKSHEQE YKNNIAKLVS
EMKIKEEGYK KEISKLYQDM QRKVELNEEK HKELIEKKEM EISELNAKLR SQEKEKQNEI
IKLQLEFDAK LARVQTKSKS YQDSTVLPQS IYRRKLQHFQ EEKNKEIAIL RNTIRDLEQR
LSVGKDSHLK RRRF
