ID   ZBT8A_XENTR             Reviewed;         470 AA.
AC   B1WAZ8;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 8A;
GN   Name=zbtb8a; Synonyms=zbtb8.1, zbtb8a.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Intestine;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC161559; AAI61559.1; -; mRNA.
DR   RefSeq; NP_001116924.1; NM_001123452.1.
DR   AlphaFoldDB; B1WAZ8; -.
DR   SMR; B1WAZ8; -.
DR   PaxDb; B1WAZ8; -.
DR   Ensembl; ENSXETT00000062168; ENSXETP00000061632; ENSXETG00000033102.
DR   GeneID; 100144694; -.
DR   KEGG; xtr:100144694; -.
DR   CTD; 100144694; -.
DR   Xenbase; XB-GENE-494386; zbtb8a.1.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; B1WAZ8; -.
DR   OrthoDB; 755439at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000033102; Expressed in testis and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..470
FT                   /note="Zinc finger and BTB domain-containing protein 8A"
FT                   /id="PRO_0000378513"
FT   DOMAIN          24..92
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         316..338
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         344..367
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   470 AA;  53315 MW;  9E94AFCDBDE35597 CRC64;
     MEFSSHHIRL LQQLDEQRRR DLFCDCHIIV EGQMFKAHRN VLFASSGYFK MLLSQSCRDM
     GEPITATFDV FSADTFTAIL DFVYSGKLPL SGQNVIEVMS AASYLQMTDV ISVCKMFIKS
     SLDINEKDRD GFFSLSDKDT GSNGSGLYAA GWRTENSPTH THETAEHGSF IAGYNYPPPI
     TSRLQRPFSK HPRKPELVRK HRRRLLPEPL TPAPLSHIPL GDLVGGSAEC MLQDEETVES
     VSLEEERAQA QETIIITKEE DEDVASHSWP ESPQQESLEQ GSALHIAKAE ELYKAMPTIL
     GGASGWGEDE ISSGRFKCPF CTHTVKRKAD LKRHLRCHTG ERPYPCEACG KRFTRLEHLR
     NHFQTIHEAG KLICRRCKLP VTKVTGRVIQ DGTRRYRLCH ACLAEAGLDN VNFDYGEDQP
     LVLPPENERE QCWNFKEEER KENGSEQAES DLVIQEVVDS EEEELKQKQD