ID   ZBTB6_BOVIN             Reviewed;         424 AA.
AC   Q0V8G8;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 6;
DE   AltName: Full=Zinc finger protein 482;
GN   Name=ZBTB6; Synonyms=ZNF482;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BT026250; ABG67089.1; -; mRNA.
DR   RefSeq; NP_001069675.1; NM_001076207.2.
DR   RefSeq; XP_005213205.1; XM_005213148.2.
DR   AlphaFoldDB; Q0V8G8; -.
DR   SMR; Q0V8G8; -.
DR   STRING; 9913.ENSBTAP00000040937; -.
DR   PaxDb; Q0V8G8; -.
DR   PRIDE; Q0V8G8; -.
DR   GeneID; 540218; -.
DR   KEGG; bta:540218; -.
DR   CTD; 10773; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_037856_1_0_1; -.
DR   InParanoid; Q0V8G8; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF333162; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..424
FT                   /note="Zinc finger and BTB domain-containing protein 6"
FT                   /id="PRO_0000274207"
FT   DOMAIN          33..97
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         301..323
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         326..348
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         354..376
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         382..405
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          403..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15916"
SQ   SEQUENCE   424 AA;  48510 MW;  44C7BB9FDC5C372B CRC64;
     MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD
     QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT
     EALSKYLEID LSMKNNNQHV DLCQSSDRDV KNEDENSDKD CEIIEISEDS PVNIDFHVKE
     EESNVLQSTV ESLTTEREEM RSPELSSVDM SFKDNEIRIL HVESISTGGV ENGKFSQPCT
     SSKASMYFSE TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSHGPVNEI QNLEDAFSLR
     HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG IRPFQCTVCL
     KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH LTSLHGRSSG EKLPRHDLER
     QNLL