ZBTB6_HUMAN
ID ZBTB6_HUMAN Reviewed; 424 AA.
AC Q15916; A8K8N6;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Zinc finger and BTB domain-containing protein 6;
DE AltName: Full=Zinc finger protein 482;
DE AltName: Full=Zinc finger protein with interaction domain;
GN Name=ZBTB6; Synonyms=ZID, ZNF482;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=7958847; DOI=10.1101/gad.8.14.1664;
RA Bardwell V.J., Treisman R.;
RT "The POZ domain: a conserved protein-protein interaction motif.";
RL Genes Dev. 8:1664-1677(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q15916; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-7227791, EBI-8468186;
CC Q15916; Q9H8W4: PLEKHF2; NbExp=6; IntAct=EBI-7227791, EBI-742388;
CC Q15916; O60260-5: PRKN; NbExp=3; IntAct=EBI-7227791, EBI-21251460;
CC Q15916; P78317: RNF4; NbExp=3; IntAct=EBI-7227791, EBI-2340927;
CC Q15916; P63165: SUMO1; NbExp=3; IntAct=EBI-7227791, EBI-80140;
CC Q15916; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-7227791, EBI-10175576;
CC Q15916; P40337-2: VHL; NbExp=3; IntAct=EBI-7227791, EBI-12157263;
CC Q15916; Q9HCK0: ZBTB26; NbExp=6; IntAct=EBI-7227791, EBI-3918996;
CC Q15916; P10074: ZBTB48; NbExp=3; IntAct=EBI-7227791, EBI-744864;
CC Q15916; P15622-3: ZNF250; NbExp=3; IntAct=EBI-7227791, EBI-10177272;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7958847}.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in brain.
CC {ECO:0000269|PubMed:7958847}.
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DR EMBL; X82018; CAA57543.1; -; mRNA.
DR EMBL; AK292401; BAF85090.1; -; mRNA.
DR EMBL; CH471090; EAW87552.1; -; Genomic_DNA.
DR EMBL; BC037282; AAH37282.1; -; mRNA.
DR CCDS; CCDS6846.1; -.
DR PIR; I39310; I39310.
DR RefSeq; NP_006617.1; NM_006626.5.
DR AlphaFoldDB; Q15916; -.
DR SMR; Q15916; -.
DR BioGRID; 115991; 13.
DR DIP; DIP-2653N; -.
DR IntAct; Q15916; 12.
DR MINT; Q15916; -.
DR STRING; 9606.ENSP00000362763; -.
DR iPTMnet; Q15916; -.
DR PhosphoSitePlus; Q15916; -.
DR BioMuta; ZBTB6; -.
DR DMDM; 46577664; -.
DR EPD; Q15916; -.
DR jPOST; Q15916; -.
DR MassIVE; Q15916; -.
DR MaxQB; Q15916; -.
DR PaxDb; Q15916; -.
DR PeptideAtlas; Q15916; -.
DR PRIDE; Q15916; -.
DR ProteomicsDB; 60817; -.
DR Antibodypedia; 30390; 230 antibodies from 28 providers.
DR DNASU; 10773; -.
DR Ensembl; ENST00000373659.4; ENSP00000362763.3; ENSG00000186130.5.
DR GeneID; 10773; -.
DR KEGG; hsa:10773; -.
DR MANE-Select; ENST00000373659.4; ENSP00000362763.3; NM_006626.6; NP_006617.1.
DR UCSC; uc004bnh.5; human.
DR CTD; 10773; -.
DR GeneCards; ZBTB6; -.
DR HGNC; HGNC:16764; ZBTB6.
DR HPA; ENSG00000186130; Low tissue specificity.
DR MIM; 605976; gene.
DR neXtProt; NX_Q15916; -.
DR OpenTargets; ENSG00000186130; -.
DR PharmGKB; PA134939601; -.
DR VEuPathDB; HostDB:ENSG00000186130; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161459; -.
DR HOGENOM; CLU_037856_1_0_1; -.
DR InParanoid; Q15916; -.
DR OMA; FRMDSMN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q15916; -.
DR TreeFam; TF333162; -.
DR PathwayCommons; Q15916; -.
DR SignaLink; Q15916; -.
DR BioGRID-ORCS; 10773; 15 hits in 1143 CRISPR screens.
DR GenomeRNAi; 10773; -.
DR Pharos; Q15916; Tdark.
DR PRO; PR:Q15916; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q15916; protein.
DR Bgee; ENSG00000186130; Expressed in cortical plate and 106 other tissues.
DR Genevisible; Q15916; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..424
FT /note="Zinc finger and BTB domain-containing protein 6"
FT /id="PRO_0000047608"
FT DOMAIN 33..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 301..323
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..405
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 402..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 424 AA; 48236 MW; 304AE4BCAE62A3BC CRC64;
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD
QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT
EALSKYLEID LSMKNNNQHT DLCQSSDPDV KNEDENSDKD CEIIEISEDS PVNIDFHVKE
EESNALQSTV ESLTSERKEM KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT
SSKASMYFSE TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG IRPFQCTVCL
KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH LTSVHGRSSG EKLSRPDLKR
QSLL
