ZBTB6_MOUSE
ID ZBTB6_MOUSE Reviewed; 423 AA.
AC Q8K088; A2AWA4; Q8BLM4;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Zinc finger and BTB domain-containing protein 6;
DE AltName: Full=Zinc finger protein 482;
GN Name=Zbtb6; Synonyms=Zfp482, Znf482;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK044125; BAC31788.1; -; mRNA.
DR EMBL; AK050827; BAC34426.1; -; mRNA.
DR EMBL; AK053443; BAC35387.1; -; mRNA.
DR EMBL; AL953890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032933; AAH32933.1; -; mRNA.
DR CCDS; CCDS16000.1; -.
DR RefSeq; NP_666365.1; NM_146253.5.
DR AlphaFoldDB; Q8K088; -.
DR SMR; Q8K088; -.
DR BioGRID; 232307; 3.
DR STRING; 10090.ENSMUSP00000108554; -.
DR iPTMnet; Q8K088; -.
DR PhosphoSitePlus; Q8K088; -.
DR PaxDb; Q8K088; -.
DR PRIDE; Q8K088; -.
DR ProteomicsDB; 302040; -.
DR Antibodypedia; 30390; 230 antibodies from 28 providers.
DR DNASU; 241322; -.
DR Ensembl; ENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798.
DR Ensembl; ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798.
DR GeneID; 241322; -.
DR KEGG; mmu:241322; -.
DR UCSC; uc008jms.2; mouse.
DR CTD; 10773; -.
DR MGI; MGI:2442998; Zbtb6.
DR VEuPathDB; HostDB:ENSMUSG00000066798; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161459; -.
DR HOGENOM; CLU_037856_1_0_1; -.
DR InParanoid; Q8K088; -.
DR OMA; FRMDSMN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8K088; -.
DR TreeFam; TF333162; -.
DR BioGRID-ORCS; 241322; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Zbtb6; mouse.
DR PRO; PR:Q8K088; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K088; protein.
DR Bgee; ENSMUSG00000066798; Expressed in dorsal pancreas and 216 other tissues.
DR Genevisible; Q8K088; MM.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..423
FT /note="Zinc finger and BTB domain-containing protein 6"
FT /id="PRO_0000047609"
FT DOMAIN 33..97
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 300..322
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..404
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q15916"
FT CONFLICT 397
FT /note="K -> E (in Ref. 1; BAC31788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 423 AA; 48188 MW; 85C9CCF7B2309C1B CRC64;
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD
QFLLTQSKHV RITILQSAEV GWKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT
EALSKYLEID LSMKNNQHTD LCQSSDTDVK NEEENSDKDC EIIEISEDSP VNLDFHVKEE
ESNALQSAAE TLTSERMRMQ SPELSAVDGG FKENEICILH VESISTDDVE NGQFSQPCTS
SKAGIYFPET QHSLINSTVE NRVTEVPGNT NQGLFSENSD GSHGTVNEIQ NLDENFSLRH
QCPRCPRGFL HVENYLRHLK MHKLFLCLQC GKTFTQKKNL NRHIRGHMGI RPFQCTVCLK
TFTAKSTLQD HLNIHSGDRP YKCHCCDMDF KHKSALKKHL TSVHGRSSGE KLSRPDLKRQ
NLL
