ZBTB9_MOUSE
ID ZBTB9_MOUSE Reviewed; 459 AA.
AC Q8CDC7; Q3U3B2; Q9CYQ0;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Zinc finger and BTB domain-containing protein 9;
GN Name=Zbtb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AK014458; BAB29365.1; -; mRNA.
DR EMBL; AK030262; BAC26866.1; -; mRNA.
DR EMBL; AK154850; BAE32876.1; -; mRNA.
DR EMBL; BC049933; AAH49933.1; -; mRNA.
DR EMBL; BC054732; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC060527; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS37520.1; -.
DR RefSeq; NP_001005916.1; NM_001005916.2.
DR AlphaFoldDB; Q8CDC7; -.
DR SMR; Q8CDC7; -.
DR BioGRID; 243089; 9.
DR IntAct; Q8CDC7; 5.
DR STRING; 10090.ENSMUSP00000112778; -.
DR PhosphoSitePlus; Q8CDC7; -.
DR EPD; Q8CDC7; -.
DR jPOST; Q8CDC7; -.
DR MaxQB; Q8CDC7; -.
DR PaxDb; Q8CDC7; -.
DR PeptideAtlas; Q8CDC7; -.
DR PRIDE; Q8CDC7; -.
DR ProteomicsDB; 275056; -.
DR DNASU; 474156; -.
DR Ensembl; ENSMUST00000120016; ENSMUSP00000112778; ENSMUSG00000079605.
DR Ensembl; ENSMUST00000133257; ENSMUSP00000115777; ENSMUSG00000117819.
DR Ensembl; ENSMUST00000237633; ENSMUSP00000157541; ENSMUSG00000079605.
DR GeneID; 474156; -.
DR KEGG; mmu:474156; -.
DR UCSC; uc008bfb.1; mouse.
DR CTD; 221504; -.
DR MGI; MGI:1918022; Zbtb9.
DR VEuPathDB; HostDB:ENSMUSG00000079605; -.
DR VEuPathDB; HostDB:ENSMUSG00000117819; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162408; -.
DR HOGENOM; CLU_029118_2_0_1; -.
DR InParanoid; Q8CDC7; -.
DR OMA; KVFYIKQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8CDC7; -.
DR BioGRID-ORCS; 474156; 3 hits in 42 CRISPR screens.
DR ChiTaRS; Zbtb9; mouse.
DR PRO; PR:Q8CDC7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8CDC7; protein.
DR Bgee; ENSMUSG00000079605; Expressed in spermatocyte and 73 other tissues.
DR Genevisible; Q8CDC7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..459
FT /note="Zinc finger and BTB domain-containing protein 9"
FT /id="PRO_0000047724"
FT DOMAIN 48..112
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 397..419
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 178..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 285
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96C00"
FT CROSSLNK 293
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96C00"
FT CROSSLNK 368
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q96C00"
FT CONFLICT 251
FT /note="P -> T (in Ref. 1; BAB29365)"
FT /evidence="ECO:0000305"
FT CONFLICT 425
FT /note="A -> V (in Ref. 1; BAB29365)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 459 AA; 49536 MW; 1984B0D0242F06D1 CRC64;
MDASTPLPPA SSSPRCNPAP QTIHIEFPHH SSSLLESLNR HRLEGKFCDV SLLVQGRELR
AHKAVLAAAS PYFHDKLLLG DAPRLTLPNV IEADAFEGLL QLIYSGSLHL PLDALPAHLL
VASGLQMWQV VDRCSEILRE LETSGGISAG GRASSLTLIS TTSSGGWCIR SSPFQNPVRS
SASTENSVLP ESPAGGEGSE LEGMLQIQVK VEEEEEQGSA APLFQTPQPE RVSGGVSQAC
GSHPLPTPAL PSKPSEDESS TVDPPAPPVQ ASQILYVNQE NVECKEEIAR GTKEKTKVLS
GEDSEEKEEL RYLLSSGGGE SSGAGDPSWK PVDLHGNEIL SGDGGPGGTG QAMHGPVKLG
GTPPADGKCF ACLCGKRFAV KPKRDRHIML TFSLRPFGCG ICNKRFKLKH HLTEHMKTHA
RALHACPHCG RRFRVQAFFL RHRDLCKGQG WPTYHWTYK
