ZC11B_HUMAN
ID ZC11B_HUMAN Reviewed; 805 AA.
AC A0A1B0GTU1;
DT 20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2016, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Zinc finger CCCH domain-containing protein 11B {ECO:0000305};
GN Name=ZC3H11B {ECO:0000312|HGNC:HGNC:25659};
GN Synonyms=ZC3HDC11B {ECO:0000312|HGNC:HGNC:25659};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: May play a role in mRNA transport. {ECO:0000305}.
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DR EMBL; AL356364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86051.1; -.
DR AlphaFoldDB; A0A1B0GTU1; -.
DR iPTMnet; A0A1B0GTU1; -.
DR PhosphoSitePlus; A0A1B0GTU1; -.
DR BioMuta; ZC3H11B; -.
DR jPOST; A0A1B0GTU1; -.
DR MassIVE; A0A1B0GTU1; -.
DR PeptideAtlas; A0A1B0GTU1; -.
DR Ensembl; ENST00000651890.1; ENSP00000498875.1; ENSG00000215817.8.
DR MANE-Select; ENST00000651890.2; ENSP00000498875.1; NM_001355457.3; NP_001342386.1.
DR GeneCards; ZC3H11B; -.
DR HGNC; HGNC:25659; ZC3H11B.
DR HPA; ENSG00000215817; Tissue enriched (testis).
DR neXtProt; NX_A0A1B0GTU1; -.
DR OpenTargets; ENSG00000215817; -.
DR VEuPathDB; HostDB:ENSG00000215817; -.
DR GeneTree; ENSGT00920000149095; -.
DR OMA; CAVEDEI; -.
DR PathwayCommons; A0A1B0GTU1; -.
DR SignaLink; A0A1B0GTU1; -.
DR Pharos; A0A1B0GTU1; Tdark.
DR PRO; PR:A0A1B0GTU1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000215817; Expressed in testis and 89 other tissues.
DR ExpressionAtlas; A0A1B0GTU1; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR041686; Znf-CCCH_3.
DR InterPro; IPR000571; Znf_CCCH.
DR Pfam; PF15663; zf-CCCH_3; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 4: Predicted;
KW Coiled coil; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..805
FT /note="Zinc finger CCCH domain-containing protein 11B"
FT /id="PRO_0000444564"
FT ZN_FING 2..29
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 31..57
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 140..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 403..423
FT /evidence="ECO:0000255"
FT COMPBIAS 176..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 88937 MW; 2F9E1922DA454BCD CRC64;
MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA LGNETVCTLW QEGRCFRRVC RFRHMEIDKK
RSEIPCYWEN QPTGCQKLNC VFHHNRGRYV DGLFLPPSKS VLPTVPESPE EEVKASQLSV
QQNKLSVQSN TSPQLRSVMK VESSENVPSP KHPPVVINAA DDDEDDDDQF SEEGDETKTP
TLQPTPEVHN GLRVTSVRKP AVNIKQGECL HFGIKTLEEI KSKKMKEKSE EQGEGSSGVS
SLLLHPEPVP GPEKENVRTV VRTVTLSTKQ GEEPLVRLGL TETLGKRKFS TGGDSDPPLK
RSLAQRLGKK VEAPETNTDE TPKKAQVSKS LKERLGMSAD PNNEDATDKV NKVGEIHVKT
LEEMLLERAS QKHGESQTKL KTEGPSKTDD STSGARSSST IRIKTFSEVL AEEEHRQQEA
ERQKSKKDTT CIKLKTDSEI KKTVVLPPIV ASKGQSEEPA GKTKSMQEVH MKTVEEIKLE
KALRVQQSSE SSTSSPSQHE ATPGARLLLR ITKRTWRKEE KKLQEGNEVD FLSRVRMEAT
EASVETTGVD ITKIQVKRCE IMRETRMQKQ QEREKSVLTP LQGDVASCNT QVAEKPVLTA
VPGITWHLTK QLPTKSSQKV EVETSGIADS LLNVKWSAQT LEKRGEAKPT VNVKQSVVKV
VSSPKLAPKR KAVEMHPAVT AAVKPLSSSS VLQEPPAKKA AVDAVVLLDS EDKSVTVPEA
ENPRDSLVLP PTQSSSDSSP PEVSGPSSSQ MSMKTRRLSS ASTGKPPLSV EDDFEKLTWE
ISGGKLEAEI DLDPGKDEDD LPLEL
