CC153_HUMAN
ID CC153_HUMAN Reviewed; 210 AA.
AC Q494R4;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Coiled-coil domain-containing protein 153;
GN Name=CCDC153;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT HIS-101.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q494R4; Q01850: CDR2; NbExp=3; IntAct=EBI-10241443, EBI-1181367;
CC Q494R4; P35638-2: DDIT3; NbExp=3; IntAct=EBI-10241443, EBI-10173632;
CC Q494R4; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-10241443, EBI-465804;
CC Q494R4; Q9H8Y8: GORASP2; NbExp=4; IntAct=EBI-10241443, EBI-739467;
CC Q494R4; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-10241443, EBI-10172876;
CC Q494R4; P37198: NUP62; NbExp=3; IntAct=EBI-10241443, EBI-347978;
CC Q494R4-2; Q13155: AIMP2; NbExp=3; IntAct=EBI-11974185, EBI-745226;
CC Q494R4-2; Q13515: BFSP2; NbExp=3; IntAct=EBI-11974185, EBI-10229433;
CC Q494R4-2; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-11974185, EBI-741214;
CC Q494R4-2; Q494R4-2: CCDC153; NbExp=5; IntAct=EBI-11974185, EBI-11974185;
CC Q494R4-2; Q01850: CDR2; NbExp=3; IntAct=EBI-11974185, EBI-1181367;
CC Q494R4-2; Q86X02: CDR2L; NbExp=3; IntAct=EBI-11974185, EBI-11063830;
CC Q494R4-2; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11974185, EBI-11986315;
CC Q494R4-2; Q14749: GNMT; NbExp=3; IntAct=EBI-11974185, EBI-744239;
CC Q494R4-2; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-11974185, EBI-11978177;
CC Q494R4-2; Q13526: PIN1; NbExp=3; IntAct=EBI-11974185, EBI-714158;
CC Q494R4-2; P52435: POLR2J; NbExp=3; IntAct=EBI-11974185, EBI-394753;
CC Q494R4-2; P25786: PSMA1; NbExp=3; IntAct=EBI-11974185, EBI-359352;
CC Q494R4-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11974185, EBI-742688;
CC Q494R4-2; Q13190: STX5; NbExp=3; IntAct=EBI-11974185, EBI-714206;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q494R4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q494R4-2; Sequence=VSP_034518;
CC -!- SIMILARITY: Belongs to the UPF0610 family. {ECO:0000305}.
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DR EMBL; AP002956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101443; AAI01444.1; -; mRNA.
DR EMBL; BC101444; AAI01445.1; -; mRNA.
DR EMBL; BC101986; AAI01987.1; -; mRNA.
DR CCDS; CCDS44753.1; -. [Q494R4-1]
DR RefSeq; NP_001138490.1; NM_001145018.1. [Q494R4-1]
DR RefSeq; XP_011541072.1; XM_011542770.2.
DR RefSeq; XP_016873069.1; XM_017017580.1.
DR AlphaFoldDB; Q494R4; -.
DR SMR; Q494R4; -.
DR BioGRID; 129477; 20.
DR IntAct; Q494R4; 18.
DR STRING; 9606.ENSP00000423567; -.
DR iPTMnet; Q494R4; -.
DR PhosphoSitePlus; Q494R4; -.
DR BioMuta; CCDC153; -.
DR DMDM; 193806578; -.
DR MassIVE; Q494R4; -.
DR PaxDb; Q494R4; -.
DR PeptideAtlas; Q494R4; -.
DR PRIDE; Q494R4; -.
DR Antibodypedia; 47797; 110 antibodies from 22 providers.
DR DNASU; 283152; -.
DR Ensembl; ENST00000415318.2; ENSP00000445431.1; ENSG00000248712.8. [Q494R4-1]
DR Ensembl; ENST00000503566.7; ENSP00000423567.2; ENSG00000248712.8. [Q494R4-1]
DR GeneID; 283152; -.
DR KEGG; hsa:283152; -.
DR MANE-Select; ENST00000503566.7; ENSP00000423567.2; NM_001145018.3; NP_001138490.1.
DR UCSC; uc058ihx.1; human. [Q494R4-1]
DR CTD; 283152; -.
DR GeneCards; CCDC153; -.
DR HGNC; HGNC:27446; CCDC153.
DR HPA; ENSG00000248712; Tissue enhanced (fallopian).
DR neXtProt; NX_Q494R4; -.
DR OpenTargets; ENSG00000248712; -.
DR PharmGKB; PA162381639; -.
DR VEuPathDB; HostDB:ENSG00000248712; -.
DR eggNOG; ENOG502S1BN; Eukaryota.
DR GeneTree; ENSGT00390000016289; -.
DR HOGENOM; CLU_088442_0_0_1; -.
DR InParanoid; Q494R4; -.
DR OMA; QDHLALR; -.
DR OrthoDB; 1357888at2759; -.
DR PhylomeDB; Q494R4; -.
DR TreeFam; TF343461; -.
DR PathwayCommons; Q494R4; -.
DR SignaLink; Q494R4; -.
DR BioGRID-ORCS; 283152; 9 hits in 1065 CRISPR screens.
DR ChiTaRS; CCDC153; human.
DR GenomeRNAi; 283152; -.
DR Pharos; Q494R4; Tdark.
DR PRO; PR:Q494R4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q494R4; protein.
DR Bgee; ENSG00000248712; Expressed in right uterine tube and 104 other tissues.
DR Genevisible; Q494R4; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR033585; CCDC153.
DR PANTHER; PTHR28656; PTHR28656; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..210
FT /note="Coiled-coil domain-containing protein 153"
FT /id="PRO_0000342650"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 49..161
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..86
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034518"
FT VARIANT 101
FT /note="R -> H (in dbSNP:rs2301574)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_044322"
SQ SEQUENCE 210 AA; 23858 MW; FA763254E95386B3 CRC64;
MPPKNKEKGK KSGAQKKKKN WGADVVAESR HRLVVLEKEL LRDHLALRRD EARRAKASED
QLRQRLQGVE AELEGARSEG KAIYAEMSRQ CHALQEDMQT RSKQLEEEVK GLRGQLEACQ
REAAAAREEA EQALGERDQA LAQLRAHMAD MEAKYEEILH DSLDRLLAKL RAIKQQWDGA
ALRLHARHKE QQRQFGLTPP GSLRPPAPSL
