ZC21A_HUMAN
ID ZC21A_HUMAN Reviewed; 325 AA.
AC Q96GY0; Q9Y372;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Zinc finger C2HC domain-containing protein 1A;
GN Name=ZC2HC1A; Synonyms=C8orf70, FAM164A; ORFNames=CGI-62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-156.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-244, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-292, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96GY0; Q8WTX7: CASTOR1; NbExp=12; IntAct=EBI-5458880, EBI-10276168;
CC Q96GY0; O43439-4: CBFA2T2; NbExp=3; IntAct=EBI-5458880, EBI-11954144;
CC Q96GY0; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-5458880, EBI-1175354;
CC Q96GY0; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-5458880, EBI-742102;
CC Q96GY0; Q14847: LASP1; NbExp=3; IntAct=EBI-5458880, EBI-742828;
CC Q96GY0; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-5458880, EBI-726739;
CC Q96GY0; O43639: NCK2; NbExp=3; IntAct=EBI-5458880, EBI-713635;
CC Q96GY0; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-5458880, EBI-948156;
CC Q96GY0; P23497: SP100; NbExp=3; IntAct=EBI-5458880, EBI-751145;
CC Q96GY0; P07947: YES1; NbExp=3; IntAct=EBI-5458880, EBI-515331;
CC -!- SIMILARITY: Belongs to the ZC2HC1 family. {ECO:0000305}.
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DR EMBL; AF151820; AAD34057.1; -; mRNA.
DR EMBL; AC100854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009074; AAH09074.1; -; mRNA.
DR CCDS; CCDS6223.1; -.
DR RefSeq; NP_057094.2; NM_016010.2.
DR AlphaFoldDB; Q96GY0; -.
DR BioGRID; 119290; 80.
DR IntAct; Q96GY0; 29.
DR STRING; 9606.ENSP00000263849; -.
DR GlyGen; Q96GY0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96GY0; -.
DR PhosphoSitePlus; Q96GY0; -.
DR BioMuta; ZC2HC1A; -.
DR DMDM; 296434498; -.
DR EPD; Q96GY0; -.
DR jPOST; Q96GY0; -.
DR MassIVE; Q96GY0; -.
DR MaxQB; Q96GY0; -.
DR PaxDb; Q96GY0; -.
DR PeptideAtlas; Q96GY0; -.
DR PRIDE; Q96GY0; -.
DR ProteomicsDB; 76682; -.
DR Antibodypedia; 12394; 282 antibodies from 20 providers.
DR DNASU; 51101; -.
DR Ensembl; ENST00000263849.9; ENSP00000263849.3; ENSG00000104427.12.
DR GeneID; 51101; -.
DR KEGG; hsa:51101; -.
DR MANE-Select; ENST00000263849.9; ENSP00000263849.3; NM_016010.3; NP_057094.2.
DR UCSC; uc003ybd.4; human.
DR CTD; 51101; -.
DR GeneCards; ZC2HC1A; -.
DR HGNC; HGNC:24277; ZC2HC1A.
DR HPA; ENSG00000104427; Tissue enhanced (skin).
DR neXtProt; NX_Q96GY0; -.
DR OpenTargets; ENSG00000104427; -.
DR PharmGKB; PA162386952; -.
DR VEuPathDB; HostDB:ENSG00000104427; -.
DR eggNOG; KOG3940; Eukaryota.
DR GeneTree; ENSGT00940000159419; -.
DR HOGENOM; CLU_855170_0_0_1; -.
DR InParanoid; Q96GY0; -.
DR OMA; DSANFCC; -.
DR OrthoDB; 1123751at2759; -.
DR PhylomeDB; Q96GY0; -.
DR TreeFam; TF319585; -.
DR PathwayCommons; Q96GY0; -.
DR SignaLink; Q96GY0; -.
DR BioGRID-ORCS; 51101; 18 hits in 1082 CRISPR screens.
DR GenomeRNAi; 51101; -.
DR Pharos; Q96GY0; Tdark.
DR PRO; PR:Q96GY0; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96GY0; protein.
DR Bgee; ENSG00000104427; Expressed in cortical plate and 205 other tissues.
DR ExpressionAtlas; Q96GY0; baseline and differential.
DR Genevisible; Q96GY0; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026319; ZC2HC1.
DR PANTHER; PTHR13555; PTHR13555; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..325
FT /note="Zinc finger C2HC domain-containing protein 1A"
FT /id="PRO_0000280246"
FT ZN_FING 15..39
FT /note="C2HC-type"
FT REGION 43..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 223
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 244
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 292
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VARIANT 156
FT /note="T -> A (in dbSNP:rs17850447)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031102"
FT CONFLICT 151
FT /note="K -> E (in Ref. 1; AAD34057)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="K -> E (in Ref. 1; AAD34057)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="T -> S (in Ref. 1; AAD34057)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35092 MW; 8ECAA1FB8B00A8BC CRC64;
MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD SSRQRAEGTD
IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA LKEGGKLPPP PPPSYDPDYI
QCPYCQRRFN ENAADRHINF CKEQAARISN KGKFSTDTKG KPTSRTQVYK PPALKKSNSP
GTASSGSSRL PQPSGAGKTV VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP
RNSTPPSLAR NPAPGVLTNK RKTYTESYIA RPDGDCASSL NGGNIKGIEG HSPGNLPKFC
HECGTKYPVE WAKFCCECGI RRMIL
