ZC21A_MOUSE
ID ZC21A_MOUSE Reviewed; 324 AA.
AC Q8BJH1; Q3TCP6;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Zinc finger C2HC domain-containing protein 1A;
GN Name=Zc2hc1a; Synonyms=Fam164a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJH1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJH1-2; Sequence=VSP_023580;
CC -!- SIMILARITY: Belongs to the ZC2HC1 family. {ECO:0000305}.
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DR EMBL; AK083941; BAC39075.1; -; mRNA.
DR EMBL; AK170609; BAE41909.1; -; mRNA.
DR EMBL; BC087731; AAH87731.1; -; mRNA.
DR CCDS; CCDS17230.1; -. [Q8BJH1-1]
DR RefSeq; NP_775273.1; NM_173181.3. [Q8BJH1-1]
DR AlphaFoldDB; Q8BJH1; -.
DR BioGRID; 212091; 4.
DR IntAct; Q8BJH1; 1.
DR STRING; 10090.ENSMUSP00000054734; -.
DR iPTMnet; Q8BJH1; -.
DR PhosphoSitePlus; Q8BJH1; -.
DR SwissPalm; Q8BJH1; -.
DR MaxQB; Q8BJH1; -.
DR PaxDb; Q8BJH1; -.
DR PeptideAtlas; Q8BJH1; -.
DR PRIDE; Q8BJH1; -.
DR ProteomicsDB; 275235; -. [Q8BJH1-1]
DR ProteomicsDB; 275236; -. [Q8BJH1-2]
DR Antibodypedia; 12394; 282 antibodies from 20 providers.
DR Ensembl; ENSMUST00000051064; ENSMUSP00000054734; ENSMUSG00000043542. [Q8BJH1-1]
DR Ensembl; ENSMUST00000193010; ENSMUSP00000141497; ENSMUSG00000043542. [Q8BJH1-2]
DR GeneID; 67306; -.
DR KEGG; mmu:67306; -.
DR UCSC; uc008oog.1; mouse. [Q8BJH1-1]
DR UCSC; uc012cnc.1; mouse. [Q8BJH1-2]
DR CTD; 51101; -.
DR MGI; MGI:1914556; Zc2hc1a.
DR VEuPathDB; HostDB:ENSMUSG00000043542; -.
DR eggNOG; KOG3940; Eukaryota.
DR GeneTree; ENSGT00940000159419; -.
DR HOGENOM; CLU_855170_0_0_1; -.
DR InParanoid; Q8BJH1; -.
DR OMA; DSANFCC; -.
DR OrthoDB; 1123751at2759; -.
DR PhylomeDB; Q8BJH1; -.
DR TreeFam; TF319585; -.
DR BioGRID-ORCS; 67306; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Zc2hc1a; mouse.
DR PRO; PR:Q8BJH1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BJH1; protein.
DR Bgee; ENSMUSG00000043542; Expressed in trigeminal ganglion and 226 other tissues.
DR Genevisible; Q8BJH1; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026319; ZC2HC1.
DR PANTHER; PTHR13555; PTHR13555; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Phosphoprotein; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..324
FT /note="Zinc finger C2HC domain-containing protein 1A"
FT /id="PRO_0000280247"
FT ZN_FING 15..39
FT /note="C2HC-type"
FT REGION 43..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GY0"
FT MOD_RES 243
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q96GY0"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96GY0"
FT VAR_SEQ 235..270
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023580"
SQ SEQUENCE 324 AA; 35152 MW; E29BE2760095D167 CRC64;
MDGLEENGSV VQVGDLLPCK ICGRTFFPLA LKKHGPICQK TATKKRKTFD SSRQRAEGTD
IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA LKEGGKLPPP PPPSYDPDYI
QCPYCQRRFN ENAADRHINF CKEQAARISN KGKFSTDSKG KPASRPQYKP SPLKKSNPPG
IPSSGSSRLP QPSTTSKTIV GVPTGKASSV NSPLGNKPQT LSPSHRAIAA PQAGANTKAR
NTTPPSLARN SVAGVLTNKR KTLTENYAAR PDGDYTSSVN GGNSKGIEGN SSGHLPKFCH
ECGTKYPVEW AKFCCECGIR RMIL
