ZC21B_HUMAN
ID ZC21B_HUMAN Reviewed; 222 AA.
AC Q5TFG8; B2RUZ7; Q5TFG9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Zinc finger C2HC domain-containing protein 1B;
GN Name=ZC2HC1B; Synonyms=C6orf94, FAM164B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5TFG8; Q8WTX7: CASTOR1; NbExp=3; IntAct=EBI-12275374, EBI-10276168;
CC Q5TFG8; Q06546: GABPA; NbExp=3; IntAct=EBI-12275374, EBI-638925;
CC Q5TFG8; O43639: NCK2; NbExp=3; IntAct=EBI-12275374, EBI-713635;
CC Q5TFG8; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-12275374, EBI-10271199;
CC Q5TFG8; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-12275374, EBI-10183064;
CC -!- SIMILARITY: Belongs to the ZC2HC1 family. {ECO:0000305}.
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DR EMBL; AL049844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47857.1; -; Genomic_DNA.
DR EMBL; BC146950; AAI46951.1; -; mRNA.
DR EMBL; BC146969; AAI46970.1; -; mRNA.
DR CCDS; CCDS47495.1; -.
DR RefSeq; NP_001013645.1; NM_001013623.2.
DR AlphaFoldDB; Q5TFG8; -.
DR BioGRID; 127527; 55.
DR IntAct; Q5TFG8; 6.
DR STRING; 9606.ENSP00000237275; -.
DR iPTMnet; Q5TFG8; -.
DR PhosphoSitePlus; Q5TFG8; -.
DR BioMuta; ZC2HC1B; -.
DR DMDM; 134035400; -.
DR MassIVE; Q5TFG8; -.
DR PaxDb; Q5TFG8; -.
DR PeptideAtlas; Q5TFG8; -.
DR PRIDE; Q5TFG8; -.
DR ProteomicsDB; 65083; -.
DR Antibodypedia; 33174; 52 antibodies from 12 providers.
DR DNASU; 153918; -.
DR Ensembl; ENST00000237275.9; ENSP00000237275.6; ENSG00000118491.10.
DR GeneID; 153918; -.
DR KEGG; hsa:153918; -.
DR MANE-Select; ENST00000237275.9; ENSP00000237275.6; NM_001013623.3; NP_001013645.1.
DR UCSC; uc010khk.4; human.
DR CTD; 153918; -.
DR DisGeNET; 153918; -.
DR GeneCards; ZC2HC1B; -.
DR HGNC; HGNC:21174; ZC2HC1B.
DR HPA; ENSG00000118491; Tissue enriched (testis).
DR neXtProt; NX_Q5TFG8; -.
DR PharmGKB; PA165617689; -.
DR VEuPathDB; HostDB:ENSG00000118491; -.
DR eggNOG; KOG3940; Eukaryota.
DR GeneTree; ENSGT00940000161511; -.
DR HOGENOM; CLU_098467_1_0_1; -.
DR InParanoid; Q5TFG8; -.
DR OMA; KRHGPIC; -.
DR OrthoDB; 1123751at2759; -.
DR PhylomeDB; Q5TFG8; -.
DR PathwayCommons; Q5TFG8; -.
DR SignaLink; Q5TFG8; -.
DR BioGRID-ORCS; 153918; 9 hits in 1017 CRISPR screens.
DR ChiTaRS; ZC2HC1B; human.
DR GenomeRNAi; 153918; -.
DR Pharos; Q5TFG8; Tdark.
DR PRO; PR:Q5TFG8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5TFG8; protein.
DR Bgee; ENSG00000118491; Expressed in left testis and 44 other tissues.
DR Genevisible; Q5TFG8; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026319; ZC2HC1.
DR PANTHER; PTHR13555; PTHR13555; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..222
FT /note="Zinc finger C2HC domain-containing protein 1B"
FT /id="PRO_0000280252"
FT ZN_FING 14..38
FT /note="C2HC-type"
FT REGION 48..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 6
FT /note="P -> S (in dbSNP:rs6934118)"
FT /id="VAR_053853"
SQ SEQUENCE 222 AA; 24665 MW; 0D4179367ED87779 CRC64;
MAGAEPFLAD GNQELFPCEV CGRRFAADVL ERHGPICKKL FNRKRKPFSS LKQRLQGTDI
PTVKKTPQSK SPPVRKSNWR QQHEDFINAI RSAKQCMLAI KEGRPLPPPP PPSLNPDYIQ
RPYCMRRFNE SAAERHTNFC KDQSSRRVFN PAQTAAKLAS RAQGRAQMGP KKEPTVTSAV
GALLQNRVLV ATNEVPTKSG LAMDPASGAK LRQGFSKSSK KD
