ZC21C_MOUSE
ID ZC21C_MOUSE Reviewed; 527 AA.
AC Q8CCG1; Q8CCM8;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc finger C2HC domain-containing protein 1C;
GN Name=Zc2hc1c; Synonyms=Fam164c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the ZC2HC1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK032455; BAC27877.1; -; mRNA.
DR EMBL; AK033213; BAC28200.1; -; mRNA.
DR EMBL; BC049940; AAH49940.1; -; mRNA.
DR CCDS; CCDS26056.1; -.
DR RefSeq; NP_766002.2; NM_172414.4.
DR RefSeq; XP_006516332.1; XM_006516269.2.
DR RefSeq; XP_006516333.1; XM_006516270.1.
DR AlphaFoldDB; Q8CCG1; -.
DR SMR; Q8CCG1; -.
DR BioGRID; 215328; 1.
DR STRING; 10090.ENSMUSP00000051664; -.
DR iPTMnet; Q8CCG1; -.
DR PhosphoSitePlus; Q8CCG1; -.
DR PaxDb; Q8CCG1; -.
DR PRIDE; Q8CCG1; -.
DR ProteomicsDB; 275237; -.
DR Antibodypedia; 25790; 57 antibodies from 19 providers.
DR DNASU; 72350; -.
DR Ensembl; ENSMUST00000059341; ENSMUSP00000051664; ENSMUSG00000045064.
DR GeneID; 72350; -.
DR KEGG; mmu:72350; -.
DR UCSC; uc007ogw.2; mouse.
DR CTD; 79696; -.
DR MGI; MGI:1919600; Zc2hc1c.
DR VEuPathDB; HostDB:ENSMUSG00000045064; -.
DR eggNOG; KOG3940; Eukaryota.
DR GeneTree; ENSGT00940000160947; -.
DR HOGENOM; CLU_039058_0_0_1; -.
DR InParanoid; Q8CCG1; -.
DR OMA; ERHSNVC; -.
DR OrthoDB; 1123751at2759; -.
DR PhylomeDB; Q8CCG1; -.
DR TreeFam; TF319585; -.
DR BioGRID-ORCS; 72350; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Zc2hc1c; mouse.
DR PRO; PR:Q8CCG1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8CCG1; protein.
DR Bgee; ENSMUSG00000045064; Expressed in spermatid and 117 other tissues.
DR ExpressionAtlas; Q8CCG1; baseline and differential.
DR Genevisible; Q8CCG1; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026104; ZNF_C2HC_dom_1C.
DR PANTHER; PTHR14649; PTHR14649; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..527
FT /note="Zinc finger C2HC domain-containing protein 1C"
FT /id="PRO_0000089942"
FT ZN_FING 378..402
FT /note="C2HC-type"
FT REGION 18..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 207..254
FT /evidence="ECO:0000255"
FT COMPBIAS 38..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="N -> K (in Ref. 1; BAC27877)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 527 AA; 59642 MW; D2746341BB2F4D06 CRC64;
MAGLQLAPHL PVGVMFPHNK TEAPGLHSAK HDPYEQSDSS QRPSMGHLRN SFQSKLWSNT
EMEQEDEVST RPKRNVCTKA RRHSCPHSAG IRQQGSGNNA QGQGKGLFYL SSPTPRYPKA
NDQDFIPFRR KRVGVDRAYP LKPMVHRKSH STSDAGADGD QNGYPRLPDS SEFSDNSFGL
RSWVNSSLLA SVQAEKVVAE LHRTEWTQIQ RLEAAGESLQ KEIRRKEILL QEKLKKTEEG
LRRMQKEKKQ AIFQEDRELQ RMVLPRRRVR DGDHDTPHKP CLSPEFRSEV FSRNRGEDQT
CDQAQENPSP RQLSDYELQK LKRERLMASN SKIRDQDAGP SADAFFQPAE ELGSTLQESS
RSGTPGSSGS SSSTEEPELA KCSHCGRSFL SLRLQRHSTV CGKMQGSKRK VFDSSRARAK
GTELEQYLNW RGPATAKAET PPPPRKSTWR QKHESFIRTL RHARQVQQVI ARGGNPSDLP
SILPADNPDY VQCPHCSRHF APKVAERHIP KCKTIKNRPP PPRRHDS
