ZC3H3_DROME
ID ZC3H3_DROME Reviewed; 597 AA.
AC Q9VSK8;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger CCCH domain-containing protein 3 {ECO:0000250|UniProtKB:Q8IXZ2};
DE AltName: Full=dZC3H3 {ECO:0000303|PubMed:19364924};
GN Name=ZC3H3 {ECO:0000312|FlyBase:FBgn0035900};
GN ORFNames=CG6694 {ECO:0000312|FlyBase:FBgn0035900};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAQ22530.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAQ22530.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAQ22530.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAQ22530.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, INTERACTION WITH SBR; PABP2 AND SWM, SUBCELLULAR LOCATION, AND
RP DOMAIN.
RX PubMed=19364924; DOI=10.1083/jcb.200811072;
RA Hurt J.A., Obar R.A., Zhai B., Farny N.G., Gygi S.P., Silver P.A.;
RT "A conserved CCCH-type zinc finger protein regulates mRNA nuclear
RT adenylation and export.";
RL J. Cell Biol. 185:265-277(2009).
CC -!- FUNCTION: Required for the export of polyadenylated mRNAs from the
CC nucleu; binds to polyadenylated mRNA, and is involved in the regulation
CC of mRNA polyadenylation. {ECO:0000269|PubMed:19364924}.
CC -!- SUBUNIT: Interacts with Pabp2, sbr and swm.
CC {ECO:0000269|PubMed:19364924}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19364924}.
CC -!- DOMAIN: The C-terminal region is required for nuclear mRNA export.
CC {ECO:0000269|PubMed:19364924}.
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DR EMBL; AE014296; AAF50410.2; -; Genomic_DNA.
DR EMBL; BT010061; AAQ22530.1; -; mRNA.
DR RefSeq; NP_648230.1; NM_139973.3.
DR AlphaFoldDB; Q9VSK8; -.
DR IntAct; Q9VSK8; 2.
DR STRING; 7227.FBpp0076380; -.
DR PaxDb; Q9VSK8; -.
DR PRIDE; Q9VSK8; -.
DR DNASU; 38968; -.
DR EnsemblMetazoa; FBtr0076656; FBpp0076380; FBgn0035900.
DR GeneID; 38968; -.
DR KEGG; dme:Dmel_CG6694; -.
DR UCSC; CG6694-RA; d. melanogaster.
DR CTD; 23144; -.
DR FlyBase; FBgn0035900; ZC3H3.
DR VEuPathDB; VectorBase:FBgn0035900; -.
DR eggNOG; KOG1492; Eukaryota.
DR GeneTree; ENSGT00940000161068; -.
DR HOGENOM; CLU_453625_0_0_1; -.
DR InParanoid; Q9VSK8; -.
DR OMA; CPYLHKK; -.
DR OrthoDB; 941054at2759; -.
DR PhylomeDB; Q9VSK8; -.
DR BioGRID-ORCS; 38968; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38968; -.
DR PRO; PR:Q9VSK8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035900; Expressed in eye disc (Drosophila) and 21 other tissues.
DR Genevisible; Q9VSK8; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0051168; P:nuclear export; IMP:FlyBase.
DR GO; GO:0010793; P:regulation of mRNA export from nucleus; IMP:UniProtKB.
DR GO; GO:1900363; P:regulation of mRNA polyadenylation; IMP:UniProtKB.
DR InterPro; IPR000571; Znf_CCCH.
DR SMART; SM00356; ZnF_C3H1; 3.
DR PROSITE; PS50103; ZF_C3H1; 3.
PE 1: Evidence at protein level;
KW Metal-binding; mRNA processing; mRNA transport; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Transport; Zinc; Zinc-finger.
FT CHAIN 1..597
FT /note="Zinc finger CCCH domain-containing protein 3"
FT /id="PRO_0000434014"
FT ZN_FING 397..423
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 424..450
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 451..478
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 515..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 66322 MW; A2D190600601BC22 CRC64;
MLPHISADEA QPSMSRKVYI NPNFQLQGQT AHQLPFQVPF QAFQAPLQPQ PAIHINPHFL
NRQRAMYDQY QREQQEQLMM QQVSASHYRL DPTIHLLATP PPPPAKIISK VSTCLVRKPS
VVASGPAVKL AASVPVPTVS SLVQPPLVSI SKRKIVRQGA LKAAPAVAAL HPPPPAKRTR
YKLVRSISLT CTPLVKKRRP LREFVGQYAL RRTNEAQPNR KLSSKPQALK LGVNKSLSMV
SIHGVMYKKI SKNKITKLDA SSSARVAKSE SPRTLQRTLS GRTLFVSGNK FILDPSGCRL
TRVSTSSTGA TQSSVNRSIL RRIDIGGLTY VASPKALNVF VRTSNHVSRA HLITAKQRSL
TLLNKSLVKT NVPCAIFQKL GKCVAHSRGK CRKLHDKRQV AICVSFLRGE CTKPKCLLSH
NVTLEKMPVC RYYLRGVCVR EDCPYLHKKL SSKTEICIDF VRGYCPLAAE CNKRHEFSCP
ELERKGKCEL PRCVFCKKSP SKRLAKVKSR PKLGSKPVAF TDTAKESSTA DELPTSSRYF
GSHKEPAEAI LTRDDVEQKK PEAEDEDQKE AGAPCPRRRP QLGTLPSFIP LGGEEKL
