ID   CC154_HUMAN             Reviewed;         667 AA.
AC   A6NI56; G9JV18;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 5.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Coiled-coil domain-containing protein 154 {ECO:0000305};
GN   Name=CCDC154 {ECO:0000312|HGNC:HGNC:34454};
GN   Synonyms=C16orf29 {ECO:0000312|HGNC:HGNC:34454};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX   PubMed=22895184; DOI=10.4161/cc.21642;
RA   Liao W., Zhao R., Lu L., Zhang R., Zou J., Xu T., Wu C., Tang J., Deng Y.,
RA   Lu X.;
RT   "Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses
RT   cell proliferation by inducing G2/M arrest.";
RL   Cell Cycle 11:3270-3279(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:22895184}.
CC   -!- MISCELLANEOUS: Overexpression suppresses cell proliferation by inducing
CC       G2/M arrest. {ECO:0000305|PubMed:22895184}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN935901; AEW67365.1; -; mRNA.
DR   EMBL; AL031600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL032819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL137252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001137452.1; NM_001143980.1.
DR   AlphaFoldDB; A6NI56; -.
DR   SMR; A6NI56; -.
DR   BioGRID; 570763; 5.
DR   IntAct; A6NI56; 1.
DR   STRING; 9606.ENSP00000373828; -.
DR   iPTMnet; A6NI56; -.
DR   PhosphoSitePlus; A6NI56; -.
DR   BioMuta; CCDC154; -.
DR   MassIVE; A6NI56; -.
DR   PaxDb; A6NI56; -.
DR   PeptideAtlas; A6NI56; -.
DR   PRIDE; A6NI56; -.
DR   DNASU; 645811; -.
DR   Ensembl; ENST00000389176.4; ENSP00000373828.4; ENSG00000197599.13.
DR   GeneID; 645811; -.
DR   KEGG; hsa:645811; -.
DR   MANE-Select; ENST00000389176.4; ENSP00000373828.4; NM_001143980.3; NP_001137452.1.
DR   UCSC; uc059oxj.1; human.
DR   CTD; 645811; -.
DR   DisGeNET; 645811; -.
DR   GeneCards; CCDC154; -.
DR   HGNC; HGNC:34454; CCDC154.
DR   MIM; 618740; gene.
DR   neXtProt; NX_A6NI56; -.
DR   OpenTargets; ENSG00000197599; -.
DR   eggNOG; ENOG502RF80; Eukaryota.
DR   GeneTree; ENSGT00390000002278; -.
DR   InParanoid; A6NI56; -.
DR   OrthoDB; 516409at2759; -.
DR   PhylomeDB; A6NI56; -.
DR   TreeFam; TF351158; -.
DR   PathwayCommons; A6NI56; -.
DR   SignaLink; A6NI56; -.
DR   BioGRID-ORCS; 645811; 4 hits in 315 CRISPR screens.
DR   GenomeRNAi; 645811; -.
DR   Pharos; A6NI56; Tdark.
DR   PRO; PR:A6NI56; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A6NI56; protein.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0035630; P:bone mineralization involved in bone maturation; IBA:GO_Central.
DR   GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR   GO; GO:0044691; P:tooth eruption; IEA:Ensembl.
DR   InterPro; IPR029512; CCDC154.
DR   PANTHER; PTHR35153; PTHR35153; 1.
DR   Pfam; PF15450; CCDC154; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..667
FT                   /note="Coiled-coil domain-containing protein 154"
FT                   /id="PRO_0000332270"
FT   COILED          76..182
FT                   /evidence="ECO:0000255"
FT   COILED          215..302
FT                   /evidence="ECO:0000255"
FT   COILED          384..410
FT                   /evidence="ECO:0000255"
FT   COILED          457..521
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   667 AA;  75408 MW;  0D022F9B7049C8FD CRC64;
     MSELADSGPS GASAPSQLRA VTLEDLGLLL AGGLASPEPL SLEELSERYE SSHPTSTASV
     PEQDTAKHWN QLEQWVVELQ AEVACLREHK QRCERATRSL LRELLQVRAR VQLQGSELRQ
     LQQEARPAAQ APEKEAPEFS GLQNQMQALD KRLVEVREAL TRLRRRQVQQ EAERRGAEQE
     AGLRLAKLTD LLQQEEQGRE VACGALQKNQ EDSSRRVDLE VARMQAQVTK LGEEVSLRFL
     KREAKLCGFL QKSFLALEKR MKASESSRLK LEGSLRGELE SRWEKLRGLM EERLRALQGQ
     HEESHLLEQC QGLDAAVAQL TKFVQQNQAS LNRVLLAEEK AWDAKGRLEE SRAGELAAYV
     QENLEAAQLA GELARQEMHG ELVLLREKSR ALEASVAQLA GQLKELSGHL PALSSRLDLQ
     EQMLGLRLSE AKTEWEGAER KSLEDLARWR KEVTEHLRGV REKVDGLPQQ IESVSDKCLL
     HKSDSDLRIS AEGKAREFKV GALRQELATL LSSVQLLKED NPGRKIAEMQ GKLATFQNQI
     MKLENCVQAN KTIQNLRFNT EARLRTQEMA TLWESVLRLW SEEGPRTPLG SWKALPSLVR
     PRVFIKDMAP GKVVPMNCWG VYQAVRWLRW KASLIKLRAL RRPGGVLEKP HSQEQVQQLT
     PSLFIQK