ZC3H6_HUMAN
ID ZC3H6_HUMAN Reviewed; 1189 AA.
AC P61129; A9JR71; Q6ZW96;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger CCCH domain-containing protein 6;
GN Name=ZC3H6; Synonyms=KIAA2035, ZC3HDC6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189.
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Yamakawa H., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-1189.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-1189.
RC TISSUE=Fetal brain, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1158, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87128.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87128.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC115115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB111887; BAC98375.1; -; mRNA.
DR EMBL; BC155540; AAI55541.1; -; mRNA.
DR EMBL; BC167154; AAI67154.1; -; mRNA.
DR EMBL; AK123404; BAC85608.1; ALT_INIT; mRNA.
DR EMBL; AK127776; BAC87128.1; ALT_SEQ; mRNA.
DR CCDS; CCDS46393.1; -.
DR RefSeq; NP_940983.2; NM_198581.2.
DR AlphaFoldDB; P61129; -.
DR BioGRID; 132014; 5.
DR IntAct; P61129; 1.
DR STRING; 9606.ENSP00000386764; -.
DR GlyGen; P61129; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P61129; -.
DR PhosphoSitePlus; P61129; -.
DR SwissPalm; P61129; -.
DR BioMuta; ZC3H6; -.
DR DMDM; 332278115; -.
DR EPD; P61129; -.
DR jPOST; P61129; -.
DR MassIVE; P61129; -.
DR MaxQB; P61129; -.
DR PaxDb; P61129; -.
DR PeptideAtlas; P61129; -.
DR PRIDE; P61129; -.
DR ProteomicsDB; 57267; -.
DR Antibodypedia; 47909; 16 antibodies from 7 providers.
DR DNASU; 376940; -.
DR Ensembl; ENST00000343936.4; ENSP00000340298.4; ENSG00000188177.14.
DR Ensembl; ENST00000409871.6; ENSP00000386764.1; ENSG00000188177.14.
DR GeneID; 376940; -.
DR KEGG; hsa:376940; -.
DR MANE-Select; ENST00000409871.6; ENSP00000386764.1; NM_198581.3; NP_940983.2.
DR UCSC; uc002thq.2; human.
DR CTD; 376940; -.
DR GeneCards; ZC3H6; -.
DR HGNC; HGNC:24762; ZC3H6.
DR HPA; ENSG00000188177; Low tissue specificity.
DR neXtProt; NX_P61129; -.
DR OpenTargets; ENSG00000188177; -.
DR PharmGKB; PA142670510; -.
DR VEuPathDB; HostDB:ENSG00000188177; -.
DR eggNOG; KOG1040; Eukaryota.
DR GeneTree; ENSGT00940000157396; -.
DR HOGENOM; CLU_008238_0_0_1; -.
DR InParanoid; P61129; -.
DR OMA; RGMKQQQ; -.
DR OrthoDB; 145192at2759; -.
DR PhylomeDB; P61129; -.
DR TreeFam; TF321641; -.
DR PathwayCommons; P61129; -.
DR SignaLink; P61129; -.
DR BioGRID-ORCS; 376940; 7 hits in 1080 CRISPR screens.
DR ChiTaRS; ZC3H6; human.
DR GenomeRNAi; 376940; -.
DR Pharos; P61129; Tdark.
DR PRO; PR:P61129; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P61129; protein.
DR Bgee; ENSG00000188177; Expressed in calcaneal tendon and 181 other tissues.
DR Genevisible; P61129; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR045124; Su(sable)-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR13119; PTHR13119; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF90229; SSF90229; 3.
DR PROSITE; PS50103; ZF_C3H1; 3.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Phosphoprotein; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..1189
FT /note="Zinc finger CCCH domain-containing protein 6"
FT /id="PRO_0000213901"
FT ZN_FING 273..299
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 301..328
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 329..352
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..73
FT /evidence="ECO:0000255"
FT COILED 353..385
FT /evidence="ECO:0000255"
FT COMPBIAS 28..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..71
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..526
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1158
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 741
FT /note="T -> A (in Ref. 4; BAC85608)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1189 AA; 131670 MW; 474CCCD8D9E4C466 CRC64;
MTDSEHAGHD REDGELEDGE IDDAGFEEIQ EKEAKENEKQ KSEKAYRKSR KKHKKEREKK
KSKRRKREKH KHNSPSSDDS SDYSLDSDVE HTESSHKKRT GFYRDYDIPF TQRGHISGSY
ITSKKGQHNK KFKSKEYDEY STYSDDNFGN YSDDNFGNYG QETEEDFANQ LKQYRQAKET
SNIALGSSFS KESGKKQRMK GVQQGIEQRV KSFNVGRGRG LPKKIKRKER GGRTNKGPNV
FSVSDDFQEY NKPGKKWKVM TQEFINQHTV EHKGKQICKY FLEGRCIKGD QCKFDHDAEL
EKRKEICKFY LQGYCTKGEN CIYMHNEFPC KFYHSGAKCY QGDNCKFSHD DLTKETKKLL
DKVLNTDEEL INEDERELEE LRKRGITPLP KPPPGVGLLP TPPEHFPFSD PEDDFQTDFS
DDFRKIPSLF EIVVKPTVDL AHKIGRKPPA FYTSASPPGP QFQGSSPHPQ HIYSSGSSPG
PGPNMSQGHS SPVMHPGSPG HHPCAGPPGL PVPQSPPLPP GPPEIVGPQN QAGVLVQPDT
SLTPPSMGGA YHSPGFPGHV MKVPRENHCS PGSSYQQSPG EMQLNTNYES LQNPAEFYDN
YYAQHSIHNF QPPNNSGDGM WHGEFAQQQP PVVQDSPNHG SGSDGSSTRT GHGPLPVPGL
LPAVQRALFV RLTQRYQEDE EQTSTQPHRA PSKEEDDTVN WYSSSEEEEG SSVKSILKTL
QKQTETLRNQ QQPSTELSTP TDPRLAKEKS KGNQVVDPRL RTIPRQDIRK PSESAPLDLR
LAWDPRKLRG NGSGHIGSSV GGAKFDLHHA NAGTNVKHKR GDDDDEDTER ELREKAFLIP
LDASPGIMLQ DPRSQLRQFS HIKMDITLTK PNFAKHIVWA PEDLLPVPLP KPDPVSSINL
PLPPLIADQR LNRLWNTKSD LHQNTVSIDP KLAAKAKINT TNREGYLEQF GDSHGSGAKL
GDPRLQKNFD PRLHRLPNTE SHQVVMKDSH ASKGAPHLPR SNPGSSQPSG AGTSNSGSGA
LPPYAPKLSS SAGLPLGTST SVLSGISLYD PRDHGSSSTS ELATASSGEN SKNQKKSGGL
KSSDKTEPSP GEAILPQKPS PNVGVTLEGP ADPQADVPRS SGKVQVPAVH SLPVQALTGL
IRPQYSDPRQ ARQPGQGSPT PDNDPGRETD DKSLKEVFKT FDPTASPFC
