ZC3H6_MOUSE
ID ZC3H6_MOUSE Reviewed; 1177 AA.
AC Q8BYK8; A2AP87; Q80UK3; Q8C1H1; Q9D604;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Zinc finger CCCH domain-containing protein 6;
GN Name=Zc3h6; Synonyms=Zc3hdc6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 215-1177 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BYK8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BYK8-2; Sequence=VSP_010212, VSP_010213;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43311.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK014766; BAB29540.1; -; mRNA.
DR EMBL; AK039171; BAC30264.1; -; mRNA.
DR EMBL; AL833780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043311; AAH43311.1; ALT_INIT; mRNA.
DR EMBL; BC058173; AAH58173.1; -; mRNA.
DR CCDS; CCDS50707.1; -. [Q8BYK8-1]
DR AlphaFoldDB; Q8BYK8; -.
DR SMR; Q8BYK8; -.
DR STRING; 10090.ENSMUSP00000105949; -.
DR iPTMnet; Q8BYK8; -.
DR PhosphoSitePlus; Q8BYK8; -.
DR MaxQB; Q8BYK8; -.
DR PaxDb; Q8BYK8; -.
DR PRIDE; Q8BYK8; -.
DR ProteomicsDB; 302044; -. [Q8BYK8-1]
DR ProteomicsDB; 302045; -. [Q8BYK8-2]
DR Antibodypedia; 47909; 16 antibodies from 7 providers.
DR Ensembl; ENSMUST00000110319; ENSMUSP00000105948; ENSMUSG00000042851. [Q8BYK8-2]
DR UCSC; uc008mha.2; mouse. [Q8BYK8-2]
DR MGI; MGI:1926001; Zc3h6.
DR VEuPathDB; HostDB:ENSMUSG00000042851; -.
DR eggNOG; KOG1040; Eukaryota.
DR GeneTree; ENSGT00940000157396; -.
DR HOGENOM; CLU_1730838_0_0_1; -.
DR InParanoid; Q8BYK8; -.
DR PhylomeDB; Q8BYK8; -.
DR ChiTaRS; Zc3h6; mouse.
DR PRO; PR:Q8BYK8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BYK8; protein.
DR Bgee; ENSMUSG00000042851; Expressed in secondary oocyte and 205 other tissues.
DR ExpressionAtlas; Q8BYK8; baseline and differential.
DR Genevisible; Q8BYK8; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR045124; Su(sable)-like.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR13119; PTHR13119; 1.
DR Pfam; PF00642; zf-CCCH; 2.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF90229; SSF90229; 3.
DR PROSITE; PS50103; ZF_C3H1; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Metal-binding; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..1177
FT /note="Zinc finger CCCH domain-containing protein 6"
FT /id="PRO_0000213902"
FT ZN_FING 271..297
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 299..326
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 327..350
FT /note="C3H1-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..73
FT /evidence="ECO:0000255"
FT COILED 347..383
FT /evidence="ECO:0000255"
FT COMPBIAS 28..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..71
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..513
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1150
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P61129"
FT VAR_SEQ 113..151
FT /note="HRRISGSYMTSKKSQHNKKTNSKEYAESSFYSDDYFGNY -> NSAITVVHL
FT QNLIHLTQKFCTSEADLLRSPLTAVLTFCL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010212"
FT VAR_SEQ 152..1177
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010213"
FT CONFLICT 469
FT /note="R -> H (in Ref. 3; AAH43311)"
FT /evidence="ECO:0000305"
FT CONFLICT 482
FT /note="K -> N (in Ref. 3; AAH43311)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="V -> M (in Ref. 3; AAH43311)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="R -> H (in Ref. 3; AAH43311)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1177 AA; 131250 MW; 6476FBE426823394 CRC64;
MTDSEHAGHD REDGELEDGE IDDAGFEETQ DQEAKENEKQ KNEKAYRKSR KKHKKEREKK
KSKRRKHEKH KHNSPSGDDS SDYSLDSDVE RMQSSRKKRT SSYRDYDVPF SQHRRISGSY
MTSKKSQHNK KTNSKEYAES SFYSDDYFGN YSDDNFGNYS NQEGEEDFSS QLKYYRQSQE
SSGSSFSKES GKKLRSKGSP PGTEYRIKSF DVSHGHLLPK KIRRKEHCGA RVIKGPYVFS
GMDDFQEYSK PGKKWKVMTQ EFINQHTVEH KGKQICKYFL EGRCIKGDHC KFNHDAELEK
KKEVCKYYLQ GYCTKGENCI YMHSEFPCKF YHSGAKCYQG DKCKFSHDDL TKETRKLLDK
VLNADEELVN EDERELEELR KRGITPLPKP PPGVGLLPTP SEHFPFSDPE DDFETDLSDD
MKKIPSLFEI VVKPTVDLAH KIGKKPPAFY NSTSPPGPQF EESSHCPQRM YSSESSPGPG
SKVPQGCESP VRHPGSPGHH PCVGPPGPPM QENPSLLPSS SEIVGPHSQA GGLVQLDTLP
SMGGAYHSPG FPGHSVKVPR ESHSSPASLY QQMPSEMQRS ADSESMQGSA EFYDDYYPQH
AAHNFQPPDN SADEMWHEEF AQQQPPIARD TAHLGSGPNS SSRMTSHCPL SASGLPPAVQ
RALFIPLTQR YQEDEEPAGT QPHRASSKEE DDTANWYSSS EEEEGSGVKS ILRTLQKQTG
TLRNQQLPPT ELSVPTDPRL AKEKRKRNQV VDPRLRTVPR QDIKKPHESV PVDLRLVWDP
KKLRGNGGAP GGSSARGAEF DLRHTNAGAN HKSKRREDDD EDSERELREK AFLIPLDSSP
GIVLQDPRSQ LRQFSHIKMD IILNKPNFAK HIVWAPEDLL PVPLPKPDPV SSINLPLPPL
IADQRLNRLW NTKSDHQGAL SLDPTSAAKA KLSLTHREGC LEQSGDLHSS GGKLGDPRLQ
KNFDPRLHRL PNTESHQVTA KDSHSSRSAL PLARWNPALS QPSTAAPINV ASVTPPLYAP
KLSSEGLPPG TSSSVLSGIS LYDPRDKGSL SATELSTISS GENTESQKKS GLKNSDKNQP
SPGEVTVPQN TTADMEVPVD GPVDMQTDIL RSADKVQVPA VHSLPIQALT GLLRPPYSDP
RQAREPGQAS PTPDEETDDK PLKEVFKTFD PTASPFC
