CC154_MOUSE
ID CC154_MOUSE Reviewed; 664 AA.
AC Q6RUT8; G9JV17; Q3V0K0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Coiled-coil domain-containing protein 154 {ECO:0000305};
DE AltName: Full=Golgin-160-like protein;
GN Name=Ccdc154 {ECO:0000312|MGI:MGI:2685163}; Synonyms=Gm317;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=22895184; DOI=10.4161/cc.21642;
RA Liao W., Zhao R., Lu L., Zhang R., Zou J., Xu T., Wu C., Tang J., Deng Y.,
RA Lu X.;
RT "Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses
RT cell proliferation by inducing G2/M arrest.";
RL Cell Cycle 11:3270-3279(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RA Brathwaite M.E., Waeltz P., Schlessinger D., Nagaraja R.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:22895184}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=3;
CC IsoId=Q6RUT8-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6RUT8-2; Sequence=VSP_060241;
CC -!- TISSUE SPECIFICITY: Expressed in brain, heart, lung, liver, spleen,
CC kidney, testis, muscle, intestine and thymus.
CC {ECO:0000269|PubMed:22895184}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS21647.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; JN935900; AEW67364.1; -; mRNA.
DR EMBL; AK133084; BAE21504.1; -; mRNA.
DR EMBL; AY491413; AAS21647.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS50032.2; -. [Q6RUT8-3]
DR RefSeq; NP_001073398.2; NM_001079929.2. [Q6RUT8-3]
DR AlphaFoldDB; Q6RUT8; -.
DR SMR; Q6RUT8; -.
DR STRING; 10090.ENSMUSP00000138090; -.
DR PhosphoSitePlus; Q6RUT8; -.
DR jPOST; Q6RUT8; -.
DR PaxDb; Q6RUT8; -.
DR PeptideAtlas; Q6RUT8; -.
DR PRIDE; Q6RUT8; -.
DR ProteomicsDB; 265580; -. [Q6RUT8-3]
DR ProteomicsDB; 265581; -. [Q6RUT8-2]
DR ProteomicsDB; 265582; -. [Q6RUT8-3]
DR Antibodypedia; 65748; 9 antibodies from 5 providers.
DR Ensembl; ENSMUST00000182621; ENSMUSP00000138090; ENSMUSG00000059562. [Q6RUT8-3]
DR GeneID; 207209; -.
DR KEGG; mmu:207209; -.
DR UCSC; uc008azx.1; mouse. [Q6RUT8-2]
DR UCSC; uc029tbf.2; mouse. [Q6RUT8-3]
DR CTD; 645811; -.
DR MGI; MGI:2685163; Ccdc154.
DR VEuPathDB; HostDB:ENSMUSG00000059562; -.
DR eggNOG; ENOG502RF80; Eukaryota.
DR GeneTree; ENSGT00390000002278; -.
DR InParanoid; Q6RUT8; -.
DR OMA; DMEKAQD; -.
DR OrthoDB; 516409at2759; -.
DR PhylomeDB; Q6RUT8; -.
DR TreeFam; TF351158; -.
DR BioGRID-ORCS; 207209; 2 hits in 74 CRISPR screens.
DR PRO; PR:Q6RUT8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6RUT8; protein.
DR Bgee; ENSMUSG00000059562; Expressed in spermatid and 8 other tissues.
DR ExpressionAtlas; Q6RUT8; baseline and differential.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0035630; P:bone mineralization involved in bone maturation; IMP:MGI.
DR GO; GO:0045453; P:bone resorption; IMP:MGI.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.
DR GO; GO:0044691; P:tooth eruption; IMP:MGI.
DR InterPro; IPR029512; CCDC154.
DR PANTHER; PTHR35153; PTHR35153; 1.
DR Pfam; PF15450; CCDC154; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Endosome; Reference proteome.
FT CHAIN 1..664
FT /note="Coiled-coil domain-containing protein 154"
FT /id="PRO_0000332271"
FT COILED 69..160
FT /evidence="ECO:0000255"
FT COILED 210..297
FT /evidence="ECO:0000255"
FT COILED 329..403
FT /evidence="ECO:0000255"
FT COILED 454..518
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..332
FT /note="Missing (in isoform 2)"
FT /id="VSP_060241"
SQ SEQUENCE 664 AA; 76128 MW; C27D246902EB597D CRC64;
MSEPADGPSL RLSPSHLSTV TLEDLELLLT EGLVSAETSE RDECSGRASG SLVPEQDTSK
LWKQLEQWVA ELQAEVVRLR GHKERCEHAT LGLLRELLQV RARVQMQASE LRQLRQVVQQ
AAWSPEKEEL ELSGPQSQNQ MQTLDKRLVE VREALTHIRR KQALQDSERK HSEQEINLRL
TNLTGMLSQE EQGREAACSA LQKNQEDTSQ KVDLGLAKMQ AQMTKLNEEM SLRFLKREAK
LCSFLQKSFL ALEQRMKSSE STRQIAESSL REELESRWQK LHELTEERLR ALRAQREEEE
GHLLEQCRGL DKAVVYLTKF VRQNQVSLNR VLMAEQKARE AKVSLEETQA GELASYVHEN
LEAVQMAGKL AQQETQDALE LLQEKSQVLE GSVAGLDQQL KDLSDHCLAL SWRLDLQEQT
LGLKLSQKQA AWEGMERESL KDLVQWLKEV TAHLEEVQEK VNSLPQQIES ISNKCVIHKS
EVDVKISAEG KAREFEVETV RQELAALLMS VQLLKEENPG RKIAEIQGQL ATFQKQMIKL
ENSLQANKTI QNLKFNNETK LRTEEIATLR ESMLRLWSEE GPWPLTLGSK RVFMSLVRQR
FFIKDVALDA MVSVNSWGVY QAVRWLRWKR FLLNLVAQKR PGVTSAMTQW KPAYEVTSLT
VFQK
