ZC3HE_DANRE
ID ZC3HE_DANRE Reviewed; 669 AA.
AC Q5TYQ8; Q1JQ57;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Zinc finger CCCH domain-containing protein 14;
GN Name=zc3h14; ORFNames=si:dkey-199i12.4, zgc:136266;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May bind to RNA. {ECO:0000250|UniProtKB:Q6PJT7}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8BJ05}.
CC Note=Colocalizes with poly(A) RNA in nuclear speckles.
CC {ECO:0000250|UniProtKB:Q8BJ05}.
CC -!- SIMILARITY: Belongs to the ZC3H14 family. {ECO:0000305}.
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DR EMBL; BX936455; CAH69025.1; -; Genomic_DNA.
DR EMBL; BC116476; AAI16477.1; -; mRNA.
DR RefSeq; NP_001020695.2; NM_001025524.2.
DR AlphaFoldDB; Q5TYQ8; -.
DR STRING; 7955.ENSDARP00000060694; -.
DR PaxDb; Q5TYQ8; -.
DR PRIDE; Q5TYQ8; -.
DR Ensembl; ENSDART00000060695; ENSDARP00000060694; ENSDARG00000041402.
DR GeneID; 562846; -.
DR KEGG; dre:562846; -.
DR CTD; 79882; -.
DR ZFIN; ZDB-GENE-041014-257; zc3h14.
DR eggNOG; KOG3702; Eukaryota.
DR GeneTree; ENSGT00440000038430; -.
DR HOGENOM; CLU_022605_0_0_1; -.
DR InParanoid; Q5TYQ8; -.
DR OMA; TFYHPTV; -.
DR OrthoDB; 893844at2759; -.
DR PhylomeDB; Q5TYQ8; -.
DR TreeFam; TF329509; -.
DR PRO; PR:Q5TYQ8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000041402; Expressed in testis and 21 other tissues.
DR ExpressionAtlas; Q5TYQ8; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IBA:GO_Central.
DR GO; GO:0043488; P:regulation of mRNA stability; IBA:GO_Central.
DR InterPro; IPR040366; Nab2/ZC3H14.
DR PANTHER; PTHR14738; PTHR14738; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding; Zinc;
KW Zinc-finger.
FT CHAIN 1..669
FT /note="Zinc finger CCCH domain-containing protein 14"
FT /id="PRO_0000331316"
FT ZN_FING 535..558
FT /note="C3H1-type 1"
FT ZN_FING 559..579
FT /note="C3H1-type 2"
FT ZN_FING 580..595
FT /note="C3H1-type 3"
FT ZN_FING 616..633
FT /note="C3H1-type 4"
FT ZN_FING 635..652
FT /note="C3H1-type 5"
FT REGION 81..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="G -> R (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="L -> I (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="R -> Q (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 505
FT /note="V -> I (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 513
FT /note="L -> F (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 526
FT /note="I -> V (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="C -> S (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="E -> G (in Ref. 2; AAI16477)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 669 AA; 74585 MW; DD58E0DA76C09A1A CRC64;
MEIGTEISKK IRTAIKGKLQ EFGAYVDEEL PDYIMVMVAN KKNPQQMADD LSLFLGNNTI
KFTVWLHGVL EKLRSVAVEP PSLGPSVVHS ETSIPAENSR RGAEPRALAV SSSRSDKAEG
RVSSSAHENR ASKRGSSERP SRLTSAVKPL MEASAEAVID IKPDLDDDLI SYDPVEHSLT
SGHSQALYSR STAERQRPAV ESSRRTADTY RSSDISRGQD RSERGYRSSA ESSRDLSRKR
KAPVASSVVR VHRGHERGLE IEDLEEEEED EDYGLASKVS LPSKPERKPT LPPAKQANKN
LILKAISEAQ ESINKTTSQY TVPQRQTVPV APRTRSASDE MSNAAIRLVQ EHLHALTPQD
TLHNTQSRGL ASRLQLEVPE EDSREPHEYE LQVLEAARLK ALDTRSFIMR QPEVEQPPPI
RSRLSAVNQN ENAPTTSRMV QARERAEAVG GSSPKFIVTL DGVPSPLANR TDQEMETEDE
LNTTADLPEN NNNNNTTTTT SKPAVHLRLG ADLRNACDDE VEEMDIEAVQ AKRQKLPERC
KFWPTCKSGD ECLYHHPNTQ CKVFPNCKFA DKCLFIHPNC KFDAKCTKAD CPFTHVSRRL
NSNPTRAAPA LTSTVCRFFP ECKKVDCPFY HPKPCRFATQ CKRADCTFYH PAVAVPPRSA
LKWTKTQSS
