ID   ZC3HE_XENLA             Reviewed;         711 AA.
AC   Q08AZ1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Zinc finger CCCH domain-containing protein 14;
GN   Name=zc3h14;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind to RNA. {ECO:0000250|UniProtKB:Q6PJT7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8BJ05}.
CC       Note=Colocalizes with poly(A) RNA in nuclear speckles.
CC       {ECO:0000250|UniProtKB:Q8BJ05}.
CC   -!- SIMILARITY: Belongs to the ZC3H14 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI24948.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC124947; AAI24948.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001121296.1; NM_001127824.1.
DR   RefSeq; XP_018087282.1; XM_018231793.1.
DR   AlphaFoldDB; Q08AZ1; -.
DR   BioGRID; 932700; 1.
DR   IntAct; Q08AZ1; 1.
DR   DNASU; 100158380; -.
DR   GeneID; 100158380; -.
DR   KEGG; xla:100158380; -.
DR   CTD; 100158380; -.
DR   Xenbase; XB-GENE-983051; zc3h14.S.
DR   OMA; KEEHTEN; -.
DR   OrthoDB; 893844at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 100158380; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008143; F:poly(A) binding; IEA:InterPro.
DR   GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IEA:InterPro.
DR   GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR   InterPro; IPR040366; Nab2/ZC3H14.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR14738; PTHR14738; 1.
DR   SMART; SM00356; ZnF_C3H1; 3.
DR   PROSITE; PS50103; ZF_C3H1; 3.
PE   2: Evidence at transcript level;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..711
FT                   /note="Zinc finger CCCH domain-containing protein 14"
FT                   /id="PRO_0000331317"
FT   ZN_FING         570..595
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         596..615
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         616..631
FT                   /note="C3H1-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         657..674
FT                   /note="C3H1-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         676..694
FT                   /note="C3H1-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          108..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  79419 MW;  6BE687E034AFEF86 CRC64;
     MTAIKGKLQE LGAYVDEELP DYIMVMVANK KSQKQMTDDL SLFLGSNTTR FTTWLQGVLD
     KLRSVTPESN SMKTSDAIIF ESSMPSLKSL SNSRDDLAKD VPTLTVSSTR HGRYDSSTSS
     HVQATGSSGS VARLTSAVKP LREFSPSEAV IDIKLDLDDP FNEDLSLATE IANLSRKRTA
     LSASYRTLRP TAEVYRPPGI GQHAYHTNEN NSSLHRFPQS SFVSGRSLKL QSSMTVGSSR
     IQDVSDLSET YKTAFRLASE KSLREEETSR KRRLPVASSV VKVKKLITDE EEVEEEGEED
     EEGTDCIFRT AGISSSVSVP AKPERRPSLP PTKQANKNLI LKAISEAQDC ISKTTNYSTA
     APQKQTVPVI PRSRLLPEEE QLMLLQNRSS LLNYPSHLQE LQHQAMPEPL HKLDLLSRLQ
     PNLEEEIELP NPVNSEEAEI LRPLDSRSFI LKRPKLSKEP SPQIQNNSVS PPCPAQPLPG
     RMIQPREAPT YEKPASPKFI VTLDGVPSPP GYISDQEVDE SMCYTEQGET CVEQLGVVAR
     PEQNYPMQLV TEPLCTNDVV MENTSSGTKE KIRERCKYWP ACKNADSCAY HHPTSPCKSF
     PNCRFADKCF FIHPNCKYDA KCKKADCPFT HASKRFPVPP VKPVSTTSSS HPSSQPCRYF
     PACKKTDCSF YHPKHCRFNT QCTRPDCKFY HPAVSVPARH TLKWTRAQAS D