ZC3HF_CHICK
ID ZC3HF_CHICK Reviewed; 429 AA.
AC Q5H7N8; Q5ZKM8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Zinc finger CCCH domain-containing protein 15;
DE AltName: Full=DRG family-regulatory protein 1;
GN Name=ZC3H15; Synonyms=DFRP1; ORFNames=RCJMB04_10a7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH DRG1, AND FUNCTION.
RX PubMed=15676025; DOI=10.1111/j.1365-2443.2005.00825.x;
RA Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.;
RT "Identification of DRG family regulatory proteins (DFRPs): specific
RT regulation of DRG1 and DRG2.";
RL Genes Cells 10:139-150(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Protects DRG1 from proteolytic degradation.
CC {ECO:0000269|PubMed:15676025}.
CC -!- SUBUNIT: Interacts with DRG1. {ECO:0000269|PubMed:15676025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ZC3H15/TMA46 family. {ECO:0000305}.
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DR EMBL; AB185935; BAD89268.1; -; mRNA.
DR EMBL; AJ720056; CAG31715.1; -; mRNA.
DR RefSeq; NP_001006510.1; NM_001006510.1.
DR AlphaFoldDB; Q5H7N8; -.
DR STRING; 9031.ENSGALP00000004195; -.
DR PaxDb; Q5H7N8; -.
DR GeneID; 423992; -.
DR KEGG; gga:423992; -.
DR CTD; 55854; -.
DR VEuPathDB; HostDB:geneid_423992; -.
DR eggNOG; KOG1763; Eukaryota.
DR InParanoid; Q5H7N8; -.
DR OrthoDB; 1358374at2759; -.
DR PhylomeDB; Q5H7N8; -.
DR PRO; PR:Q5H7N8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR InterPro; IPR032378; ZC3H15/TMA46_C.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR Pfam; PF16543; DFRP_C; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..429
FT /note="Zinc finger CCCH domain-containing protein 15"
FT /id="PRO_0000324645"
FT ZN_FING 100..127
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 175..213
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..261
FT /note="Required for interaction with DRG1"
FT /evidence="ECO:0000250"
FT REGION 301..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..87
FT /evidence="ECO:0000255"
FT COILED 219..285
FT /evidence="ECO:0000255"
FT COMPBIAS 14..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..400
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 44
FT /note="F -> I (in Ref. 2; CAG31715)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="L -> Q (in Ref. 2; CAG31715)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="Y -> N (in Ref. 2; CAG31715)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 48997 MW; FC376BFB0D0B14AF CRC64;
MPPKKQQQPA GSSKKADQKK KEKIIEDKTF GLKNKKGAKQ QKFFKAVTHL VKFGQQYPRQ
AAQTESEKKL KKEDKKKELQ ELNELFKPVV AAQKISKGAD PKSVVCAFFK QGQCTKGDKC
KFSHDLSLER KCEKRSVYID ARDEDLEKDT MDNWDEKKLE EVVNKKHGEA EKKKPKTQIV
CKYFLDAIEN NKYGWFWVCP GGGDNCMYRH ALPPGFVLKK DKKKEEKQDE ISLEDLIEKE
RAALGPNVTK ITLECFIAWK RRKRQEKIDK AEQDMERRKA DFKAGKALVI SGREVFEFRP
ELVDADDEEA DDTRYTQGTG EDDEVEDPVC VNDVDLSLYV PKAVDETGIT VASPERFSTY
ASIEKDDNKL SEASGGEINS SEQNDLEDRD GDEELENGVM DAVPVDENLF TGEDLDELEE
ELNTLDLEE
