ID   ZC3HF_DANRE             Reviewed;         433 AA.
AC   Q803J8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Zinc finger CCCH domain-containing protein 15;
GN   Name=zc3h15; Synonyms=dfrp1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects drg1 from proteolytic degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with drg1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZC3H15/TMA46 family. {ECO:0000305}.
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DR   EMBL; BC044451; AAH44451.1; -; mRNA.
DR   RefSeq; NP_956182.1; NM_199888.1.
DR   AlphaFoldDB; Q803J8; -.
DR   SMR; Q803J8; -.
DR   STRING; 7955.ENSDARP00000017582; -.
DR   PaxDb; Q803J8; -.
DR   GeneID; 334307; -.
DR   KEGG; dre:334307; -.
DR   CTD; 55854; -.
DR   ZFIN; ZDB-GENE-030131-6239; zc3h15.
DR   eggNOG; KOG1763; Eukaryota.
DR   InParanoid; Q803J8; -.
DR   OrthoDB; 1358374at2759; -.
DR   PhylomeDB; Q803J8; -.
DR   PRO; PR:Q803J8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   InterPro; IPR032378; ZC3H15/TMA46_C.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   Pfam; PF16543; DFRP_C; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..433
FT                   /note="Zinc finger CCCH domain-containing protein 15"
FT                   /id="PRO_0000324646"
FT   ZN_FING         99..126
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         175..213
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..262
FT                   /note="Required for interaction with DRG1"
FT                   /evidence="ECO:0000250"
FT   REGION          358..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          57..86
FT                   /evidence="ECO:0000255"
FT   COILED          217..288
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        373..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  49214 MW;  86947E410B36103F CRC64;
     MPPKKPAPAA ANKKTQEKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTQQV KFGQQNARQI
     AAAESEKTKK KDDKKKELSE LNELFKPVVA AQKVSKGVDP KSVLCAFFKQ GQCTKGDKCK
     FSHDLSLERK CEKRSLYVDG RDDELLEKDT MENWDEKKLE EVVNKKHGEA EKKKAKTQIV
     CKYFLDAIEN NKYGWFWVCP GGGDNCMYRH ALPVGFVLKK DKKNEEKNEE EISLEDLIET
     ERSLLGANVT RITLETFLAW KKRKRQEKLA KAEQDMERKK ADFKAGRALG VSGREVFEFR
     PELVDDDDEE ADDTKYAEED YNYGMSNQVE DTEEVQDIDI ARFIPKEVDN AGITVASADR
     FTAKAPPTND IDDNKLSEAS GGTMENGEHS EDQTLEDGET NEESEAVPVD ENLFTGEDLD
     ELEEELNTLD LDE