CC157_HUMAN
ID CC157_HUMAN Reviewed; 752 AA.
AC Q569K6; Q0VD76; Q9BYA4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Coiled-coil domain-containing protein 157;
GN Name=CCDC157; Synonyms=KIAA1656;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 83-140.
RC TISSUE=Brain;
RX PubMed=11258795; DOI=10.1093/dnares/8.1.1;
RA Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.;
RT "Identification of novel transcribed sequences on human chromosome 22 by
RT expressed sequence tag mapping.";
RL DNA Res. 8:1-9(2001).
CC -!- INTERACTION:
CC Q569K6; Q8NCF5-2: NFATC2IP; NbExp=3; IntAct=EBI-13289565, EBI-12305293;
CC Q569K6; Q15560: TCEA2; NbExp=3; IntAct=EBI-13289565, EBI-710310;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH92419.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'- and 3'-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};
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DR EMBL; AC004997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092419; AAH92419.1; ALT_INIT; mRNA.
DR EMBL; BC119799; AAI19800.1; -; mRNA.
DR EMBL; BC127255; AAI27256.1; -; mRNA.
DR EMBL; AB051443; BAB33326.1; ALT_SEQ; mRNA.
DR CCDS; CCDS33632.2; -.
DR RefSeq; NP_001017437.2; NM_001017437.3.
DR RefSeq; NP_001305263.1; NM_001318334.1.
DR AlphaFoldDB; Q569K6; -.
DR SMR; Q569K6; -.
DR BioGRID; 139247; 4.
DR IntAct; Q569K6; 2.
DR STRING; 9606.ENSP00000385357; -.
DR iPTMnet; Q569K6; -.
DR PhosphoSitePlus; Q569K6; -.
DR BioMuta; CCDC157; -.
DR DMDM; 296439417; -.
DR EPD; Q569K6; -.
DR jPOST; Q569K6; -.
DR MassIVE; Q569K6; -.
DR MaxQB; Q569K6; -.
DR PaxDb; Q569K6; -.
DR PeptideAtlas; Q569K6; -.
DR PRIDE; Q569K6; -.
DR ProteomicsDB; 62579; -.
DR Antibodypedia; 45362; 39 antibodies from 12 providers.
DR DNASU; 550631; -.
DR Ensembl; ENST00000338306.8; ENSP00000343087.3; ENSG00000187860.11.
DR Ensembl; ENST00000405659.5; ENSP00000385357.1; ENSG00000187860.11.
DR GeneID; 550631; -.
DR KEGG; hsa:550631; -.
DR MANE-Select; ENST00000338306.8; ENSP00000343087.3; NM_001017437.5; NP_001017437.3.
DR UCSC; uc011aku.3; human.
DR CTD; 550631; -.
DR DisGeNET; 550631; -.
DR GeneCards; CCDC157; -.
DR HGNC; HGNC:33854; CCDC157.
DR HPA; ENSG00000187860; Tissue enhanced (testis).
DR MIM; 619391; gene.
DR neXtProt; NX_Q569K6; -.
DR PharmGKB; PA164717678; -.
DR VEuPathDB; HostDB:ENSG00000187860; -.
DR eggNOG; ENOG502QPW2; Eukaryota.
DR GeneTree; ENSGT00390000013684; -.
DR HOGENOM; CLU_019717_2_0_1; -.
DR InParanoid; Q569K6; -.
DR OMA; RQPCASP; -.
DR OrthoDB; 807018at2759; -.
DR PhylomeDB; Q569K6; -.
DR TreeFam; TF334443; -.
DR PathwayCommons; Q569K6; -.
DR SignaLink; Q569K6; -.
DR BioGRID-ORCS; 550631; 12 hits in 1075 CRISPR screens.
DR ChiTaRS; CCDC157; human.
DR GenomeRNAi; 550631; -.
DR Pharos; Q569K6; Tdark.
DR PRO; PR:Q569K6; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q569K6; protein.
DR Bgee; ENSG00000187860; Expressed in right uterine tube and 107 other tissues.
DR ExpressionAtlas; Q569K6; baseline and differential.
DR InterPro; IPR029681; CCDC157.
DR PANTHER; PTHR43696; PTHR43696; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..752
FT /note="Coiled-coil domain-containing protein 157"
FT /id="PRO_0000319420"
FT REGION 135..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 276..544
FT /evidence="ECO:0000255"
FT COILED 579..615
FT /evidence="ECO:0000255"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..696
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 51
FT /note="D -> N (in dbSNP:rs740223)"
FT /id="VAR_060124"
FT VARIANT 191
FT /note="P -> L (in dbSNP:rs12167903)"
FT /id="VAR_038999"
FT VARIANT 587
FT /note="S -> A (in dbSNP:rs2015035)"
FT /id="VAR_039000"
FT CONFLICT 16
FT /note="T -> A (in Ref. 2; AAH92419/AAI19800/AAI27256)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 752 AA; 83941 MW; 4652B5B0F26A9BCC CRC64;
MAHLLGSQAC MESLRTDLTD LQGAIVDVFS RAGPVRFPSW KFPDRMACDL DMVALLEHYD
HVPGDPEFTQ LSHAVLLELV IDRLLLLLQS CMSYLENLGS EQMMPPAQAA GPCMSVGLTV
RRFWDSLLRL GTLHQQPLPQ KGANQRETPT SKPTTKGEPA RSPEYLTTKL IKPSSPVLGL
PQTCQEPESI PVRASLQFPA TTFKNTRSVH SQTIETALVP CDACASVQGS LQKVGKVVIS
LCQSQNLPSS LGQFQQLVQD SMGLRPLPAA TVGRWAAEQR KDLTRLSKHV EALRAQLEEA
EGQKDGLRKQ AGKLEQALKQ EQGARRRQAE EDEQCLSEWE HDKQQLLTET SDLKTKMATL
ERELKQQRES TQAVEAKAQQ LQEEGERRAA AERQVQQLEE QVQQLEAQVQ LLVGRLEGAG
QQVCWASTEL DKEKARVDSM VRHQESLQAK QRALLKQLDS LDQEREELRG SLDEAEAQRA
RVEEQLQSER EQGQCQLRAQ QELLQSLQRE KQGLEQATTD LRLTILELER ELEELKERER
LLVAFPDLHR PTETQIHGGR SSSVESQITC PTDSGNVTDH MERQVQSNDI RIRVLQEENG
RLQSMLSKIR EVAQQGGLKL IPQDRLWSPS SKGTQGATPP VQAKSTSPGP LGRQHLPSSR
TGRTLLGQPC TSPPRQPCTS PPRQPCTSPP RQPCTSPSRQ PCSQPSKSLL EGVTHLDTCT
QNPIKVLVRL RKRLSPGRGQ ASSAHQPQER PM
