ID   ZC3HF_XENLA             Reviewed;         426 AA.
AC   Q6DD06;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Zinc finger CCCH domain-containing protein 15;
DE   AltName: Full=DRG family-regulatory protein 1;
GN   Name=zc3h15; Synonyms=dfrp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15676025; DOI=10.1111/j.1365-2443.2005.00825.x;
RA   Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.;
RT   "Identification of DRG family regulatory proteins (DFRPs): specific
RT   regulation of DRG1 and DRG2.";
RL   Genes Cells 10:139-150(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects drg1 from proteolytic degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with drg1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in ovary. Moderately expressed
CC       in brain, kidney, spleen, testis, intestine and colon.
CC       {ECO:0000269|PubMed:15676025}.
CC   -!- DEVELOPMENTAL STAGE: Weakly expressed in late gastrula. Strongly
CC       expressed from late neurula (stages 20-22) to tadpole (stages 40-41).
CC       At stage 22, expressed in blood islands, somites, eyes, trunk neural
CC       crest, mandibular crest segment, hyoid crest segment and branchial
CC       crest segment. At stage 32, expressed in otic vesicle, pronephros,
CC       forebraiin, midbrain, hindbrain, branchial arch, eyes, lens, spinal
CC       cord and notochord. {ECO:0000269|PubMed:15676025}.
CC   -!- SIMILARITY: Belongs to the ZC3H15/TMA46 family. {ECO:0000305}.
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DR   EMBL; AB185934; BAD89267.1; -; mRNA.
DR   EMBL; BC077826; AAH77826.1; -; mRNA.
DR   RefSeq; NP_001086961.1; NM_001093492.1.
DR   AlphaFoldDB; Q6DD06; -.
DR   SMR; Q6DD06; -.
DR   BioGRID; 103656; 1.
DR   IntAct; Q6DD06; 1.
DR   DNASU; 446796; -.
DR   GeneID; 446796; -.
DR   KEGG; xla:446796; -.
DR   CTD; 446796; -.
DR   Xenbase; XB-GENE-5800445; zc3h15.L.
DR   OMA; LWQCPNG; -.
DR   OrthoDB; 1358374at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446796; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR032378; ZC3H15/TMA46_C.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   Pfam; PF16543; DFRP_C; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..426
FT                   /note="Zinc finger CCCH domain-containing protein 15"
FT                   /id="PRO_0000324647"
FT   ZN_FING         100..127
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         175..213
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          237..261
FT                   /note="Required for interaction with DRG1"
FT                   /evidence="ECO:0000250"
FT   COILED          62..87
FT                   /evidence="ECO:0000255"
FT   COILED          257..283
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  48713 MW;  931A7E117094FC2B CRC64;
     MPPKKAPAAP QASKKTEQKK KEKIIEDKTF GLKNKKGAKQ QKFIKNVTHQ VKSGQQNPRL
     VAQAEGDKKN KKDDKMKELQ ELNDLFKPVV VAQKVSKGAD PKSVVCAFFK QGQCTKGDKC
     KFSHDLSLER KCEKRSVYVD GRDDELEKDT MENWDEKKLE EVVNKKHGEA EKIKAKTQIV
     CKFFLEAIEN NKYGWFWVCP GGGDTCMYRH ALPPGFVLKK EKVKEDKDED ISLEDLIEKE
     RAALGPNVTR ITLESFLQWK KRKRADRILK LEEEMEKRKE DFKSGKSLGV SGREVFEFRP
     ELINDDDEEA DDASYTFELE DSEAEEIDDV QDIDLSRYVL KDVDETGITV ASCERFSSYV
     ASTEKDENKL CVASGGVMEN ENQSEEEQEG DLENGFVDAV PVDENLFTGE DMDELEEELY
     TLDLEK