ID   ZC3HF_XENTR             Reviewed;         426 AA.
AC   A4IGY3; Q28F75;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Zinc finger CCCH domain-containing protein 15;
GN   Name=zc3h15; ORFNames=TGas113m05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects drg1 from proteolytic degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with drg1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZC3H15/TMA46 family. {ECO:0000305}.
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DR   EMBL; CR762127; CAJ83795.1; -; mRNA.
DR   EMBL; BC135295; AAI35296.1; -; mRNA.
DR   RefSeq; NP_001016105.1; NM_001016105.2.
DR   AlphaFoldDB; A4IGY3; -.
DR   STRING; 8364.ENSXETP00000029225; -.
DR   PaxDb; A4IGY3; -.
DR   GeneID; 548859; -.
DR   KEGG; xtr:548859; -.
DR   CTD; 55854; -.
DR   Xenbase; XB-GENE-5800360; zc3h15.
DR   eggNOG; KOG1763; Eukaryota.
DR   HOGENOM; CLU_042870_3_0_1; -.
DR   InParanoid; A4IGY3; -.
DR   OrthoDB; 1358374at2759; -.
DR   TreeFam; TF300892; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   InterPro; IPR032378; ZC3H15/TMA46_C.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   Pfam; PF16543; DFRP_C; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..426
FT                   /note="Zinc finger CCCH domain-containing protein 15"
FT                   /id="PRO_0000324648"
FT   ZN_FING         100..127
FT                   /note="C3H1-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         175..213
FT                   /note="C3H1-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          237..261
FT                   /note="Required for interaction with DRG1"
FT                   /evidence="ECO:0000250"
FT   REGION          374..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          219..283
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        14..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        48
FT                   /note="I -> T (in Ref. 1; CAJ83795)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   426 AA;  49014 MW;  ECCA1348F987BF8D CRC64;
     MPPKKAPAAP QSGKKTEQKK KEKIIEDKTF GLKNKKGAKQ QKFIKNVIHQ VKFGQQNPRL
     VAQAEGEKKT KKDDKKKELL ELNDLFKPVV AAQKVSKGAD PKSVVCAFYK QGQCTKGDKC
     KFSHDLSLER KCEKRSVYVD GRDEELEKDT MENWDEKKLE EVVNKKHGEA EKIKPKTQIV
     CKFFLEAIEN NKYGWFWVCP GGGDMCMYRH ALPPGFVLKK DKKKEEKDEE ISLEDLIERE
     RAGLGLNVTR ITLESFLEWK KRKRQDRIVK LEEEMEKRKA DFKAGKSLGI SGREVFEFRP
     ELINDDDEEA DDTDYIFDKE DSDSETADDI KDIDLSRFVL KDVDETGITV ASCERFSSYV
     ISTEKDEEKL CVASGGEMEN EDQSEEQQEN DLENGFVDAV PVDENLFTGE DMDELEEELY
     TLDLEK