ZCC17_MOUSE
ID ZCC17_MOUSE Reviewed; 241 AA.
AC Q9ESX4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Zinc finger CCHC domain-containing protein 17;
DE AltName: Full=Nucleolar protein of 40 kDa {ECO:0000303|PubMed:12893261};
DE Short=pNO40 {ECO:0000303|PubMed:12893261};
DE AltName: Full=Putative S1 RNA-binding domain protein;
DE Short=PS1D protein;
GN Name=Zcchc17; Synonyms=Ps1d; ORFNames=Ldc4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING,
RP IDENTIFICATION IN THE 60 S RIBOSOMAL SUBUNIT, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=12202495; DOI=10.1074/jbc.m208551200;
RA Gueydan C., Wauquier C., De Mees C., Huez G., Kruys V.;
RT "Identification of ribosomal proteins specific to higher eukaryotic
RT organisms.";
RL J. Biol. Chem. 277:45034-45040(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Colon, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=12893261; DOI=10.1016/s0006-291x(03)01208-7;
RA Chang W.-L., Lee D.-C., Leu S., Huang Y.-M., Lu M.-C., Ouyang P.;
RT "Molecular characterization of a novel nucleolar protein, pNO40.";
RL Biochem. Biophys. Res. Commun. 307:569-577(2003).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBUNIT: Interacts with PNN (By similarity). Associates with the 60S
CC ribosomal subunit. {ECO:0000250, ECO:0000269|PubMed:12202495}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12202495,
CC ECO:0000269|PubMed:12893261}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ESX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ESX4-2; Sequence=VSP_015309;
CC -!- TISSUE SPECIFICITY: Expressed in liver, brain, heart, kidney testis,
CC stomach, small intestine, skin, thymus, uterus, placenta, spleen, lung
CC and skeletal muscle. {ECO:0000269|PubMed:12202495,
CC ECO:0000269|PubMed:12893261}.
CC -!- MISCELLANEOUS: [Isoform 2]: Less abundant than isoform 1.
CC {ECO:0000305}.
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DR EMBL; AJ272345; CAC03718.1; -; mRNA.
DR EMBL; AY253297; AAO83392.1; -; mRNA.
DR EMBL; BC018382; AAH18382.1; -; mRNA.
DR EMBL; BC049231; AAH49231.1; -; mRNA.
DR CCDS; CCDS38891.1; -. [Q9ESX4-1]
DR RefSeq; NP_694800.1; NM_153160.4. [Q9ESX4-1]
DR RefSeq; XP_006503322.1; XM_006503259.1.
DR RefSeq; XP_006503323.1; XM_006503260.1.
DR AlphaFoldDB; Q9ESX4; -.
DR SMR; Q9ESX4; -.
DR BioGRID; 546920; 5.
DR IntAct; Q9ESX4; 1.
DR STRING; 10090.ENSMUSP00000120807; -.
DR iPTMnet; Q9ESX4; -.
DR PhosphoSitePlus; Q9ESX4; -.
DR EPD; Q9ESX4; -.
DR MaxQB; Q9ESX4; -.
DR PaxDb; Q9ESX4; -.
DR PRIDE; Q9ESX4; -.
DR ProteomicsDB; 252979; -. [Q9ESX4-1]
DR ProteomicsDB; 252980; -. [Q9ESX4-2]
DR Antibodypedia; 31100; 196 antibodies from 23 providers.
DR Ensembl; ENSMUST00000134159; ENSMUSP00000120807; ENSMUSG00000028772. [Q9ESX4-1]
DR GeneID; 619605; -.
DR KEGG; mmu:619605; -.
DR UCSC; uc008uze.1; mouse. [Q9ESX4-1]
DR CTD; 51538; -.
DR MGI; MGI:1919955; Zcchc17.
DR VEuPathDB; HostDB:ENSMUSG00000028772; -.
DR eggNOG; KOG0922; Eukaryota.
DR GeneTree; ENSGT00510000047363; -.
DR HOGENOM; CLU_068074_0_0_1; -.
DR InParanoid; Q9ESX4; -.
DR OMA; SEMVDVG; -.
DR PhylomeDB; Q9ESX4; -.
DR TreeFam; TF332136; -.
DR BioGRID-ORCS; 619605; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Zcchc17; mouse.
DR PRO; PR:Q9ESX4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9ESX4; protein.
DR Bgee; ENSMUSG00000028772; Expressed in undifferentiated genital tubercle and 71 other tissues.
DR ExpressionAtlas; Q9ESX4; baseline and differential.
DR Genevisible; Q9ESX4; MM.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0043489; P:RNA stabilization; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR037320; pNO40.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR15838:SF1; PTHR15838:SF1; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; Zinc; Zinc-finger.
FT CHAIN 1..241
FT /note="Zinc finger CCHC domain-containing protein 17"
FT /id="PRO_0000096904"
FT DOMAIN 16..88
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT ZN_FING 131..148
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 160..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..241
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NP64"
FT MOD_RES 144
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 183
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NP64"
FT VAR_SEQ 1..48
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12202495"
FT /id="VSP_015309"
SQ SEQUENCE 241 AA; 27472 MW; C6F6B3B420716167 CRC64;
MNSGRPETME NLPALYTIFQ GEVAMVTDYG AFIKIPGCRK QGLVHRTHMS SCRVDKPSEI
VDVGDKVWVK LIGREMKNDR IKVSLSMKVV NQGTGKDLDP NNVVIEQEER RRRSFQDYTG
QKITLEAVLN TTCKKCGCKG HFAKDCFMQP GGTKYSLIPE EEEEKEEAKA EGLEKPDPTK
NSSRKRKKEK KKKKHRDRKS SDCDSSDSES DTGKKARHSS KDSKATKKKK KKKKHKKKHK
E
