ZCC18_HUMAN
ID ZCC18_HUMAN Reviewed; 403 AA.
AC P0CG32;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Zinc finger CCHC domain-containing protein 18 {ECO:0000305};
GN Name=ZCCHC18 {ECO:0000312|HGNC:HGNC:32459};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the ZCCHC12 family. {ECO:0000305}.
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DR EMBL; Z82254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS65304.1; -.
DR RefSeq; NP_001137450.1; NM_001143978.2.
DR RefSeq; XP_011529314.1; XM_011531012.2.
DR AlphaFoldDB; P0CG32; -.
DR BioGRID; 569537; 3.
DR STRING; 9606.ENSP00000482195; -.
DR PhosphoSitePlus; P0CG32; -.
DR BioMuta; ZCCHC18; -.
DR DMDM; 300681209; -.
DR MassIVE; P0CG32; -.
DR PeptideAtlas; P0CG32; -.
DR PRIDE; P0CG32; -.
DR ProteomicsDB; 52462; -.
DR Antibodypedia; 71724; 15 antibodies from 7 providers.
DR DNASU; 644353; -.
DR Ensembl; ENST00000537356.3; ENSP00000473824.1; ENSG00000166707.12.
DR Ensembl; ENST00000650639.1; ENSP00000498828.1; ENSG00000166707.12.
DR GeneID; 644353; -.
DR KEGG; hsa:644353; -.
DR MANE-Select; ENST00000650639.1; ENSP00000498828.1; NM_001143978.3; NP_001137450.1.
DR UCSC; uc011msh.4; human.
DR CTD; 644353; -.
DR GeneCards; ZCCHC18; -.
DR HGNC; HGNC:32459; ZCCHC18.
DR HPA; ENSG00000166707; Tissue enhanced (brain, ovary).
DR neXtProt; NX_P0CG32; -.
DR OpenTargets; ENSG00000166707; -.
DR PharmGKB; PA162409569; -.
DR VEuPathDB; HostDB:ENSG00000166707; -.
DR eggNOG; ENOG502RU0T; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_686127_0_0_1; -.
DR InParanoid; P0CG32; -.
DR OMA; TIFCSYC; -.
DR OrthoDB; 697027at2759; -.
DR PhylomeDB; P0CG32; -.
DR PathwayCommons; P0CG32; -.
DR SignaLink; P0CG32; -.
DR BioGRID-ORCS; 644353; 10 hits in 676 CRISPR screens.
DR GenomeRNAi; 644353; -.
DR Pharos; P0CG32; Tdark.
DR PRO; PR:P0CG32; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P0CG32; protein.
DR Bgee; ENSG00000166707; Expressed in cortical plate and 120 other tissues.
DR Genevisible; P0CG32; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026523; PNMA.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR Pfam; PF14893; PNMA; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..403
FT /note="Zinc finger CCHC domain-containing protein 18"
FT /id="PRO_0000395361"
FT ZN_FING 347..364
FT /note="CCHC-type"
FT REGION 312..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45160 MW; F2194FBF417DB209 CRC64;
MASITACVGN SRQQNAPLPP WAHSMLRSLG RSLCPLVVKM AERNMKLFSG RVVPAQGKET
FENWLIQVNE VLPDWSMSEE EKLKRLMKTL RGPAREVMRL LQAANPNLSV ADFLRAMKLV
FGESESSVTA HGKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGILAEKDA NQTRLQQLLL
GAELNRDLRF RLKHLLRMYA NKQERLPNFL ELIKMIREEE DWDDAFIKRK RPKRSEPIME
RAASPVAFQG AQPIAISSAD CNCNVIEIDD TLDDSDEDVI LVVSLYPSLT PTGAPPFRGR
ARPLDQVLVI DSPNNSGAQS LSTSGGSGYK NDGPGNIRRA RKRKYTTRCS YCGEEGHSKE
TCDNESNKAQ VFENLIITLQ ELTHTEERSK EVPGEHSDAS EPQ
