CC157_MOUSE
ID CC157_MOUSE Reviewed; 718 AA.
AC Q5SPX1; Q0P531; Q3V0G5; Q5DTW1; Q8C5Y5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Coiled-coil domain-containing protein 157;
GN Name=Ccdc157; Synonyms=Kiaa1656;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SPX1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SPX1-2; Sequence=VSP_031476;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD90260.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE21539.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK076934; BAC36532.1; -; mRNA.
DR EMBL; AK133165; BAE21539.1; ALT_INIT; mRNA.
DR EMBL; AK220409; BAD90260.1; ALT_INIT; mRNA.
DR EMBL; AL807825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120737; AAI20738.1; -; mRNA.
DR EMBL; BC120739; AAI20740.1; -; mRNA.
DR CCDS; CCDS24379.1; -. [Q5SPX1-2]
DR CCDS; CCDS48743.1; -. [Q5SPX1-1]
DR RefSeq; NP_001158092.1; NM_001164620.1. [Q5SPX1-1]
DR RefSeq; NP_808284.2; NM_177616.3. [Q5SPX1-2]
DR AlphaFoldDB; Q5SPX1; -.
DR SMR; Q5SPX1; -.
DR STRING; 10090.ENSMUSP00000091074; -.
DR iPTMnet; Q5SPX1; -.
DR PhosphoSitePlus; Q5SPX1; -.
DR MaxQB; Q5SPX1; -.
DR PaxDb; Q5SPX1; -.
DR PeptideAtlas; Q5SPX1; -.
DR PRIDE; Q5SPX1; -.
DR ProteomicsDB; 281242; -. [Q5SPX1-1]
DR ProteomicsDB; 281243; -. [Q5SPX1-2]
DR Antibodypedia; 45362; 39 antibodies from 12 providers.
DR DNASU; 216516; -.
DR Ensembl; ENSMUST00000093381; ENSMUSP00000091074; ENSMUSG00000051427. [Q5SPX1-1]
DR Ensembl; ENSMUST00000101626; ENSMUSP00000099148; ENSMUSG00000051427. [Q5SPX1-2]
DR GeneID; 216516; -.
DR KEGG; mmu:216516; -.
DR UCSC; uc007hul.1; mouse. [Q5SPX1-1]
DR CTD; 550631; -.
DR MGI; MGI:3041210; Ccdc157.
DR VEuPathDB; HostDB:ENSMUSG00000051427; -.
DR eggNOG; ENOG502QPW2; Eukaryota.
DR GeneTree; ENSGT00390000013684; -.
DR HOGENOM; CLU_019717_2_0_1; -.
DR InParanoid; Q5SPX1; -.
DR OrthoDB; 807018at2759; -.
DR PhylomeDB; Q5SPX1; -.
DR TreeFam; TF334443; -.
DR BioGRID-ORCS; 216516; 7 hits in 72 CRISPR screens.
DR PRO; PR:Q5SPX1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SPX1; protein.
DR Bgee; ENSMUSG00000051427; Expressed in olfactory epithelium and 206 other tissues.
DR Genevisible; Q5SPX1; MM.
DR InterPro; IPR029681; CCDC157.
DR PANTHER; PTHR43696; PTHR43696; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..718
FT /note="Coiled-coil domain-containing protein 157"
FT /id="PRO_0000319421"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 300..603
FT /evidence="ECO:0000255"
FT COMPBIAS 626..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.2"
FT /id="VSP_031476"
FT CONFLICT 172
FT /note="K -> R (in Ref. 1; BAC36532)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 718 AA; 79795 MW; 0BDA02B37F460194 CRC64;
MAHLLGSQAC MDSLRKDLTD LQGTIVDVFS RAGPVRFPSW KFPDRVACDL DMVALLEHYD
HVPGDPEFTQ LSHAVLLELV IDRLLLLLQS CASYLENLSV EQMMPPARAA GPCMSVGLTV
RRFWSNLLRL GLLYQQAVPQ KRANQGEISI TKPTAKGEPA RSPECMTAKF IKPPSPVPGL
PLICQGLQSI PVRVSLRSPG GTSEKTKSVY SQTVETALVP CDACTSVQGS LWEVGKVVIS
LCQSQNLPSS LGQFQKLVKD SLGLKPLPAA TVGHWAAEQS KDLTRLNKHV GALTQLVGPL
RAQLEDAEGQ KDGLRKQVSK LEQALQQEQG QRQRQTEEAE RTLAKCEHDR HQLLTETCDL
KTKVAVLEGD LKQQQKSIQA MEAKAQQLEE EGERRAAAER QVQQLEEQVQ LLAGRLDGAS
QQIRWASTEL DKEKARVDSM VRHQESLQAK QRTLLQQLDC LDQEREELRG SLDEAEAQRS
ELEEQLQSLQ SDREQEQCQL QAQQELLQSL QQEKQDLEQV TTDLQLTISE LRQQLEELKE
RERLLVAFPD LHQPEEAQIQ SSSNVTQDME RQVQANAIRI QVLQEENKRL QSMLTKIREV
AQQGGLKMVP QGQLWSPPYK GIQGATPPAQ AQSAFSGLTG RRQSPGSRTS STGRTHPGGL
RTSPSRQPGG LPSKFSLGDG SHSASCTQNP IRALARLRRK LSPNRQAGST YQPQERPT
