ZCC18_MOUSE
ID ZCC18_MOUSE Reviewed; 393 AA.
AC Q8VD24; Q9DB17;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Zinc finger CCHC domain-containing protein 18 {ECO:0000305};
GN Name=Zcchc18 {ECO:0000312|MGI:MGI:1914245};
GN Synonyms=Sizn2 {ECO:0000312|EMBL:AAT67149.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Brain;
RA Cho G., Lim Y., Golden J.;
RT "Sizn2 expressed in developing mouse brain.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Cerebellum, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the ZCCHC12 family. {ECO:0000305}.
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DR EMBL; AY650116; AAT67149.1; -; mRNA.
DR EMBL; AK005317; BAB23950.1; -; mRNA.
DR EMBL; AK075607; BAC35854.1; -; mRNA.
DR EMBL; AK134856; BAE22314.1; -; mRNA.
DR EMBL; AL672008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466616; EDL23889.1; -; Genomic_DNA.
DR EMBL; CH466616; EDL23890.1; -; Genomic_DNA.
DR EMBL; BC017627; AAH17627.1; -; mRNA.
DR CCDS; CCDS30427.1; -.
DR RefSeq; NP_001030586.1; NM_001035509.1.
DR RefSeq; NP_001030587.1; NM_001035510.1.
DR RefSeq; NP_080169.2; NM_025893.2.
DR RefSeq; XP_006528657.1; XM_006528594.1.
DR RefSeq; XP_011246059.1; XM_011247757.2.
DR RefSeq; XP_017174097.1; XM_017318608.1.
DR RefSeq; XP_017174098.1; XM_017318609.1.
DR AlphaFoldDB; Q8VD24; -.
DR STRING; 10090.ENSMUSP00000033804; -.
DR iPTMnet; Q8VD24; -.
DR PhosphoSitePlus; Q8VD24; -.
DR MaxQB; Q8VD24; -.
DR PaxDb; Q8VD24; -.
DR PRIDE; Q8VD24; -.
DR ProteomicsDB; 275271; -.
DR Ensembl; ENSMUST00000033804; ENSMUSP00000033804; ENSMUSG00000031428.
DR Ensembl; ENSMUST00000101227; ENSMUSP00000098788; ENSMUSG00000031428.
DR Ensembl; ENSMUST00000113067; ENSMUSP00000108690; ENSMUSG00000031428.
DR GeneID; 66995; -.
DR KEGG; mmu:66995; -.
DR UCSC; uc009ujk.1; mouse.
DR CTD; 644353; -.
DR MGI; MGI:1914245; Zcchc18.
DR VEuPathDB; HostDB:ENSMUSG00000031428; -.
DR eggNOG; ENOG502RU0T; Eukaryota.
DR GeneTree; ENSGT01030000234522; -.
DR HOGENOM; CLU_686127_0_0_1; -.
DR InParanoid; Q8VD24; -.
DR OMA; TIFCSYC; -.
DR OrthoDB; 697027at2759; -.
DR PhylomeDB; Q8VD24; -.
DR TreeFam; TF335054; -.
DR BioGRID-ORCS; 66995; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Zcchc18; mouse.
DR PRO; PR:Q8VD24; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8VD24; protein.
DR Bgee; ENSMUSG00000031428; Expressed in ventromedial nucleus of hypothalamus and 196 other tissues.
DR Genevisible; Q8VD24; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR026523; PNMA.
DR PANTHER; PTHR23095; PTHR23095; 1.
DR Pfam; PF14893; PNMA; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..393
FT /note="Zinc finger CCHC domain-containing protein 18"
FT /id="PRO_0000395362"
FT ZN_FING 346..363
FT /note="CCHC-type"
FT REGION 281..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 255
FT /note="I -> M (in Ref. 2; BAB23950)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 43975 MW; DD2DEA24596452AB CRC64;
MASLLARMGN SRRQNAAFMP FAHSMLRALG RSLGPLIANI AERNIQSFSG RAELGPGEET
FENWLSQVHE VLPDWPMSEE EKIKRLMRTL RGPAREAMRL FQADNPNLNV AEFLRAMKLL
FGASESSITA HGKFLSTLQA QGEKPSLYVI RLEVQLQNAI QAGVLPQSEA NRTRLHQLLV
GAELSRELRT KLKGLLQMHA HNEQENLPDF LELIRMIREE EDWDETFLRN KRPRRSETVM
ERAASPVVFQ GSLPIVIGSA DCNVIEIDDS QDDSDEDVIL VEPEDPPLSS PGASSLRGTA
STQEEMLIIE SPDDFDEESP STSSGSGQRN NGPGDLGRTR KRKYPIRCPH CGEEGHAKET
CDNTSNKGQV FENLIVTLQE LTHMERPKPS VPY
