ZCCHL_HUMAN
ID ZCCHL_HUMAN Reviewed; 300 AA.
AC Q96H79; Q8WUD9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger CCCH-type antiviral protein 1-like;
GN Name=ZC3HAV1L; Synonyms=C7orf39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-12; 142-154 AND 249-291, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V.;
RL Submitted (JAN-2010) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96H79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96H79-2; Sequence=VSP_033210, VSP_033211;
CC -!- CAUTION: Despite its name, it does not contain a canonical C3H1-type
CC zinc-finger. {ECO:0000305}.
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DR EMBL; AC083868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008842; AAH08842.1; -; mRNA.
DR EMBL; BC020784; AAH20784.1; -; mRNA.
DR CCDS; CCDS5850.1; -. [Q96H79-1]
DR RefSeq; NP_542391.2; NM_080660.3. [Q96H79-1]
DR AlphaFoldDB; Q96H79; -.
DR SMR; Q96H79; -.
DR BioGRID; 124907; 30.
DR IntAct; Q96H79; 7.
DR MINT; Q96H79; -.
DR STRING; 9606.ENSP00000275766; -.
DR iPTMnet; Q96H79; -.
DR MetOSite; Q96H79; -.
DR PhosphoSitePlus; Q96H79; -.
DR BioMuta; ZC3HAV1L; -.
DR DMDM; 296453031; -.
DR EPD; Q96H79; -.
DR jPOST; Q96H79; -.
DR MassIVE; Q96H79; -.
DR MaxQB; Q96H79; -.
DR PaxDb; Q96H79; -.
DR PeptideAtlas; Q96H79; -.
DR PRIDE; Q96H79; -.
DR ProteomicsDB; 76710; -. [Q96H79-1]
DR ProteomicsDB; 76711; -. [Q96H79-2]
DR Antibodypedia; 18221; 82 antibodies from 18 providers.
DR DNASU; 92092; -.
DR Ensembl; ENST00000275766.2; ENSP00000275766.1; ENSG00000146858.8. [Q96H79-1]
DR GeneID; 92092; -.
DR KEGG; hsa:92092; -.
DR MANE-Select; ENST00000275766.2; ENSP00000275766.1; NM_080660.4; NP_542391.2.
DR UCSC; uc003vum.1; human. [Q96H79-1]
DR CTD; 92092; -.
DR GeneCards; ZC3HAV1L; -.
DR HGNC; HGNC:22423; ZC3HAV1L.
DR HPA; ENSG00000146858; Low tissue specificity.
DR neXtProt; NX_Q96H79; -.
DR OpenTargets; ENSG00000146858; -.
DR PharmGKB; PA145147600; -.
DR VEuPathDB; HostDB:ENSG00000146858; -.
DR eggNOG; ENOG502T12H; Eukaryota.
DR GeneTree; ENSGT00710000106871; -.
DR HOGENOM; CLU_085581_0_0_1; -.
DR InParanoid; Q96H79; -.
DR OMA; MLGKCPH; -.
DR OrthoDB; 782733at2759; -.
DR PhylomeDB; Q96H79; -.
DR TreeFam; TF338389; -.
DR PathwayCommons; Q96H79; -.
DR SignaLink; Q96H79; -.
DR BioGRID-ORCS; 92092; 14 hits in 1073 CRISPR screens.
DR ChiTaRS; ZC3HAV1L; human.
DR GenomeRNAi; 92092; -.
DR Pharos; Q96H79; Tdark.
DR PRO; PR:Q96H79; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96H79; protein.
DR Bgee; ENSG00000146858; Expressed in adrenal tissue and 97 other tissues.
DR Genevisible; Q96H79; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR041360; ZAP_HTH.
DR InterPro; IPR026693; Zc3hav1-like.
DR PANTHER; PTHR47621; PTHR47621; 1.
DR Pfam; PF18606; HTH_53; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330"
FT CHAIN 2..300
FT /note="Zinc finger CCCH-type antiviral protein 1-like"
FT /id="PRO_0000331459"
FT REGION 252..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330"
FT VAR_SEQ 87..102
FT /note="SVRLCARYQRGECQAC -> GTIGACHHTQLIFLGF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033210"
FT VAR_SEQ 103..300
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033211"
FT CONFLICT 244
FT /note="M -> I (in Ref. 2; AAH08842)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 32962 MW; 9F3B6BABA5CA0E3B CRC64;
MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL
GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD
CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG
YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST
YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK
