ZCCHL_MOUSE
ID ZCCHL_MOUSE Reviewed; 296 AA.
AC Q8BFR1; Q8C3Z2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Zinc finger CCCH-type antiviral protein 1-like;
GN Name=Zc3hav1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BFR1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BFR1-2; Sequence=VSP_033212;
CC -!- CAUTION: Despite its name, it does not contain a canonical C3H1-type
CC zinc-finger. {ECO:0000305}.
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DR EMBL; AK045287; BAC32297.1; -; mRNA.
DR EMBL; AK051064; BAC34514.1; -; mRNA.
DR EMBL; AK084475; BAC39193.1; -; mRNA.
DR CCDS; CCDS20011.1; -. [Q8BFR1-1]
DR RefSeq; NP_766055.1; NM_172467.3. [Q8BFR1-1]
DR AlphaFoldDB; Q8BFR1; -.
DR SMR; Q8BFR1; -.
DR BioGRID; 229041; 1.
DR STRING; 10090.ENSMUSP00000062475; -.
DR PhosphoSitePlus; Q8BFR1; -.
DR EPD; Q8BFR1; -.
DR MaxQB; Q8BFR1; -.
DR PaxDb; Q8BFR1; -.
DR PeptideAtlas; Q8BFR1; -.
DR PRIDE; Q8BFR1; -.
DR ProteomicsDB; 298500; -. [Q8BFR1-1]
DR ProteomicsDB; 298501; -. [Q8BFR1-2]
DR Antibodypedia; 18221; 82 antibodies from 18 providers.
DR Ensembl; ENSMUST00000058524; ENSMUSP00000062475; ENSMUSG00000047749. [Q8BFR1-1]
DR GeneID; 209032; -.
DR KEGG; mmu:209032; -.
DR UCSC; uc009bjx.2; mouse. [Q8BFR1-1]
DR CTD; 92092; -.
DR MGI; MGI:2443387; Zc3hav1l.
DR VEuPathDB; HostDB:ENSMUSG00000047749; -.
DR eggNOG; ENOG502T12H; Eukaryota.
DR GeneTree; ENSGT00710000106871; -.
DR HOGENOM; CLU_085581_0_0_1; -.
DR InParanoid; Q8BFR1; -.
DR OMA; MLGKCPH; -.
DR PhylomeDB; Q8BFR1; -.
DR TreeFam; TF338389; -.
DR BioGRID-ORCS; 209032; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Zc3hav1l; mouse.
DR PRO; PR:Q8BFR1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BFR1; protein.
DR Bgee; ENSMUSG00000047749; Expressed in manus and 186 other tissues.
DR ExpressionAtlas; Q8BFR1; baseline and differential.
DR Genevisible; Q8BFR1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR041360; ZAP_HTH.
DR InterPro; IPR026693; Zc3hav1-like.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR47621; PTHR47621; 1.
DR Pfam; PF18606; HTH_53; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96H79"
FT CHAIN 2..296
FT /note="Zinc finger CCCH-type antiviral protein 1-like"
FT /id="PRO_0000331460"
FT ZN_FING 111..136
FT /note="C3H1-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT ZN_FING 198..219
FT /note="C3H1-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96H79"
FT VAR_SEQ 1..86
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033212"
SQ SEQUENCE 296 AA; 32831 MW; FA8A8ABB9EEA7FDA CRC64;
MADLTLCAFL TKVLCAHGGR MFLQDLRGHV ELSEAKLRAV LRRAGPERFL LQEVELRDGP
WDAEAEVAAG EGAGAGSGGG ATACRVMAVS SARLCARYQR GECQGCDQLH LCRRHMLGKC
PHRDCWSTCS LSHDIHTPIN VQVLKSRGLF GLNEGQLRIL LLQNDPCLFP EVCQMYNKGV
DVLYGYCSLK DRCNKFHVCK SFVRGECPFQ PCKRSHQLIH AATLKLLEDQ ELSVSSVVNF
QIISVYRHKK LHKMLEEKDH SASTEQPQGL GKQGALGAVE ARPFLPARAQ SPRKPQ
