ZCH10_HUMAN
ID ZCH10_HUMAN Reviewed; 192 AA.
AC Q8TBK6; Q9NXR4;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zinc finger CCHC domain-containing protein 10;
GN Name=ZCCHC10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8TBK6; Q8N2N9-4: ANKRD36B; NbExp=3; IntAct=EBI-597063, EBI-12170453;
CC Q8TBK6; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-597063, EBI-10181188;
CC Q8TBK6; Q6NZI2: CAVIN1; NbExp=3; IntAct=EBI-597063, EBI-2559016;
CC Q8TBK6; Q96MT8: CEP63; NbExp=3; IntAct=EBI-597063, EBI-741977;
CC Q8TBK6; Q8NHQ1: CEP70; NbExp=4; IntAct=EBI-597063, EBI-739624;
CC Q8TBK6; P38432: COIL; NbExp=3; IntAct=EBI-597063, EBI-945751;
CC Q8TBK6; O75553: DAB1; NbExp=3; IntAct=EBI-597063, EBI-7875264;
CC Q8TBK6; Q9UI36-2: DACH1; NbExp=3; IntAct=EBI-597063, EBI-10186082;
CC Q8TBK6; Q86Y13: DZIP3; NbExp=6; IntAct=EBI-597063, EBI-948630;
CC Q8TBK6; Q8IYF1: ELOA2; NbExp=3; IntAct=EBI-597063, EBI-741705;
CC Q8TBK6; P11171-2: EPB41; NbExp=3; IntAct=EBI-597063, EBI-10197451;
CC Q8TBK6; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-597063, EBI-10175124;
CC Q8TBK6; Q5VSY0: GKAP1; NbExp=3; IntAct=EBI-597063, EBI-743722;
CC Q8TBK6; Q9UGU5: HMGXB4; NbExp=5; IntAct=EBI-597063, EBI-7261162;
CC Q8TBK6; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-597063, EBI-2511344;
CC Q8TBK6; O00505: KPNA3; NbExp=3; IntAct=EBI-597063, EBI-358297;
CC Q8TBK6; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-597063, EBI-739832;
CC Q8TBK6; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-597063, EBI-10268010;
CC Q8TBK6; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-597063, EBI-348259;
CC Q8TBK6; P50221: MEOX1; NbExp=3; IntAct=EBI-597063, EBI-2864512;
CC Q8TBK6; O95848: NUDT14; NbExp=3; IntAct=EBI-597063, EBI-536866;
CC Q8TBK6; Q9NZ81: PRR13; NbExp=4; IntAct=EBI-597063, EBI-740924;
CC Q8TBK6; P61289: PSME3; NbExp=7; IntAct=EBI-597063, EBI-355546;
CC Q8TBK6; P26045: PTPN3; NbExp=3; IntAct=EBI-597063, EBI-1047946;
CC Q8TBK6; Q14498: RBM39; NbExp=4; IntAct=EBI-597063, EBI-395290;
CC Q8TBK6; Q14498-3: RBM39; NbExp=3; IntAct=EBI-597063, EBI-6654703;
CC Q8TBK6; P35268: RPL22; NbExp=3; IntAct=EBI-597063, EBI-354533;
CC Q8TBK6; O00560: SDCBP; NbExp=3; IntAct=EBI-597063, EBI-727004;
CC Q8TBK6; Q9H190: SDCBP2; NbExp=4; IntAct=EBI-597063, EBI-742426;
CC Q8TBK6; Q15427: SF3B4; NbExp=3; IntAct=EBI-597063, EBI-348469;
CC Q8TBK6; Q9UHJ3: SFMBT1; NbExp=6; IntAct=EBI-597063, EBI-747398;
CC Q8TBK6; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-597063, EBI-747107;
CC Q8TBK6; Q96MF2: STAC3; NbExp=7; IntAct=EBI-597063, EBI-745680;
CC Q8TBK6; O75558: STX11; NbExp=4; IntAct=EBI-597063, EBI-714135;
CC Q8TBK6; Q12800: TFCP2; NbExp=4; IntAct=EBI-597063, EBI-717422;
CC Q8TBK6; Q9NVV9: THAP1; NbExp=10; IntAct=EBI-597063, EBI-741515;
CC Q8TBK6; O43829: ZBTB14; NbExp=3; IntAct=EBI-597063, EBI-10176632;
CC Q8TBK6; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-597063, EBI-742740;
CC Q8TBK6; Q5ZXN6: ankX; Xeno; NbExp=2; IntAct=EBI-597063, EBI-26359852;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TBK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TBK6-2; Sequence=VSP_013718;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK000101; BAA90946.1; -; mRNA.
DR EMBL; BC005211; AAH05211.1; -; mRNA.
DR EMBL; BC022443; AAH22443.1; -; mRNA.
DR CCDS; CCDS4165.1; -. [Q8TBK6-2]
DR CCDS; CCDS75301.1; -. [Q8TBK6-1]
DR RefSeq; NP_001287745.1; NM_001300816.2. [Q8TBK6-1]
DR RefSeq; NP_001287746.1; NM_001300817.2.
DR RefSeq; NP_001287747.1; NM_001300818.2.
DR RefSeq; NP_001287748.1; NM_001300819.2.
DR RefSeq; NP_001287751.1; NM_001300822.2.
DR RefSeq; NP_001295056.1; NM_001308127.1.
DR RefSeq; NP_001295057.1; NM_001308128.1.
DR RefSeq; NP_001295058.1; NM_001308129.1.
DR RefSeq; NP_001295059.1; NM_001308130.1.
DR RefSeq; NP_060135.1; NM_017665.3. [Q8TBK6-2]
DR AlphaFoldDB; Q8TBK6; -.
DR BioGRID; 120174; 234.
DR IntAct; Q8TBK6; 66.
DR MINT; Q8TBK6; -.
DR STRING; 9606.ENSP00000423276; -.
DR iPTMnet; Q8TBK6; -.
DR PhosphoSitePlus; Q8TBK6; -.
DR BioMuta; ZCCHC10; -.
DR DMDM; 84028163; -.
DR EPD; Q8TBK6; -.
DR jPOST; Q8TBK6; -.
DR MassIVE; Q8TBK6; -.
DR MaxQB; Q8TBK6; -.
DR PeptideAtlas; Q8TBK6; -.
DR PRIDE; Q8TBK6; -.
DR ProteomicsDB; 74024; -. [Q8TBK6-1]
DR ProteomicsDB; 74025; -. [Q8TBK6-2]
DR Antibodypedia; 26217; 31 antibodies from 11 providers.
DR DNASU; 54819; -.
DR Ensembl; ENST00000324170.7; ENSP00000324274.3; ENSG00000155329.12. [Q8TBK6-2]
DR Ensembl; ENST00000509437.6; ENSP00000423276.1; ENSG00000155329.12. [Q8TBK6-1]
DR GeneID; 54819; -.
DR KEGG; hsa:54819; -.
DR MANE-Select; ENST00000509437.6; ENSP00000423276.1; NM_001300816.3; NP_001287745.1.
DR UCSC; uc003kyg.4; human. [Q8TBK6-1]
DR CTD; 54819; -.
DR DisGeNET; 54819; -.
DR GeneCards; ZCCHC10; -.
DR HGNC; HGNC:25954; ZCCHC10.
DR HPA; ENSG00000155329; Low tissue specificity.
DR neXtProt; NX_Q8TBK6; -.
DR OpenTargets; ENSG00000155329; -.
DR PharmGKB; PA134876515; -.
DR VEuPathDB; HostDB:ENSG00000155329; -.
DR eggNOG; KOG3116; Eukaryota.
DR GeneTree; ENSGT00730000111200; -.
DR HOGENOM; CLU_111178_0_0_1; -.
DR InParanoid; Q8TBK6; -.
DR OMA; RKYVQRT; -.
DR OrthoDB; 1638633at2759; -.
DR PhylomeDB; Q8TBK6; -.
DR PathwayCommons; Q8TBK6; -.
DR SignaLink; Q8TBK6; -.
DR BioGRID-ORCS; 54819; 16 hits in 1077 CRISPR screens.
DR ChiTaRS; ZCCHC10; human.
DR GenomeRNAi; 54819; -.
DR Pharos; Q8TBK6; Tdark.
DR PRO; PR:Q8TBK6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TBK6; protein.
DR Bgee; ENSG00000155329; Expressed in endothelial cell and 207 other tissues.
DR ExpressionAtlas; Q8TBK6; baseline and differential.
DR Genevisible; Q8TBK6; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR039715; ZCCHC10.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR13491; PTHR13491; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..192
FT /note="Zinc finger CCHC domain-containing protein 10"
FT /id="PRO_0000150967"
FT ZN_FING 43..60
FT /note="CCHC-type"
FT REGION 89..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 15..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_013718"
SQ SEQUENCE 192 AA; 20967 MW; E600FD109936B53E CRC64;
MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE FGHWTYECTG
KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA KKKRSKSVTS SSSSSSDSSA
SDSSSESEET STSSSSEDSD TDESSSSSSS SASSTTSSSS SDSDSDSSSS SSSSTSTDSS
SDDEPPKKKK KK
