CC159_HUMAN
ID CC159_HUMAN Reviewed; 297 AA.
AC P0C7I6; B4DEG3; B4DWR8; B4E133; B7ZAM4;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Coiled-coil domain-containing protein 159;
GN Name=CCDC159;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-189 (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-230 (ISOFORM 2).
RC TISSUE=Cerebellum, Esophagus, Spleen, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-292 (ISOFORMS 2/4).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=2;
CC IsoId=P0C7I6-2; Sequence=Displayed;
CC Name=3;
CC IsoId=P0C7I6-6; Sequence=VSP_059513, VSP_059514, VSP_059515;
CC Name=4;
CC IsoId=P0C7I6-7; Sequence=VSP_059513;
CC Name=5;
CC IsoId=P0C7I6-8; Sequence=VSP_059514, VSP_059515;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG63130.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BC038439; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AK293611; BAG57074.1; -; mRNA.
DR EMBL; AK301653; BAG63130.1; ALT_SEQ; mRNA.
DR EMBL; AK303641; BAG64645.1; -; mRNA.
DR EMBL; AK316339; BAH14710.1; -; mRNA.
DR EMBL; AC024575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038439; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45976.1; -. [P0C7I6-2]
DR RefSeq; NP_001073972.2; NM_001080503.2. [P0C7I6-2]
DR RefSeq; XP_016881749.1; XM_017026260.1. [P0C7I6-7]
DR AlphaFoldDB; P0C7I6; -.
DR SMR; P0C7I6; -.
DR BioGRID; 125955; 1.
DR IntAct; P0C7I6; 1.
DR MINT; P0C7I6; -.
DR STRING; 9606.ENSP00000468232; -.
DR iPTMnet; P0C7I6; -.
DR PhosphoSitePlus; P0C7I6; -.
DR BioMuta; CCDC159; -.
DR DMDM; 189041677; -.
DR MassIVE; P0C7I6; -.
DR PaxDb; P0C7I6; -.
DR PeptideAtlas; P0C7I6; -.
DR PRIDE; P0C7I6; -.
DR Antibodypedia; 52093; 16 antibodies from 8 providers.
DR DNASU; 126075; -.
DR Ensembl; ENST00000458408.6; ENSP00000402239.1; ENSG00000183401.12. [P0C7I6-2]
DR Ensembl; ENST00000588790.5; ENSP00000468232.1; ENSG00000183401.12. [P0C7I6-2]
DR GeneID; 126075; -.
DR KEGG; hsa:126075; -.
DR MANE-Select; ENST00000458408.6; ENSP00000402239.1; NM_001080503.3; NP_001073972.2.
DR UCSC; uc010xlt.3; human. [P0C7I6-2]
DR CTD; 126075; -.
DR GeneCards; CCDC159; -.
DR HGNC; HGNC:26996; CCDC159.
DR HPA; ENSG00000183401; Low tissue specificity.
DR neXtProt; NX_P0C7I6; -.
DR OpenTargets; ENSG00000183401; -.
DR VEuPathDB; HostDB:ENSG00000183401; -.
DR eggNOG; ENOG502S2FS; Eukaryota.
DR GeneTree; ENSGT00390000008201; -.
DR HOGENOM; CLU_081600_0_0_1; -.
DR InParanoid; P0C7I6; -.
DR OMA; QKECCND; -.
DR OrthoDB; 1360515at2759; -.
DR PhylomeDB; P0C7I6; -.
DR PathwayCommons; P0C7I6; -.
DR SignaLink; P0C7I6; -.
DR BioGRID-ORCS; 126075; 49 hits in 1079 CRISPR screens.
DR GenomeRNAi; 126075; -.
DR Pharos; P0C7I6; Tdark.
DR PRO; PR:P0C7I6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0C7I6; protein.
DR Bgee; ENSG00000183401; Expressed in granulocyte and 153 other tissues.
DR ExpressionAtlas; P0C7I6; baseline and differential.
DR Genevisible; P0C7I6; HS.
DR InterPro; IPR039284; CCDC159/163.
DR PANTHER; PTHR34533; PTHR34533; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..297
FT /note="Coiled-coil domain-containing protein 159"
FT /id="PRO_0000332996"
FT REGION 256..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..297
FT /evidence="ECO:0000255"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..6
FT /note="MGEHEQ -> MNRWY (in isoform 3 and isoform 4)"
FT /id="VSP_059513"
FT VAR_SEQ 141..177
FT /note="SKKFLWEELELVREEVTFIYQKLQAQEDEISENLVNI -> RSGMAGGQLGV
FT HRREGRPRTGEWRQDGGNGRCLGEGD (in isoform 3 and isoform 5)"
FT /id="VSP_059514"
FT VAR_SEQ 178..297
FT /note="Missing (in isoform 3 and isoform 5)"
FT /id="VSP_059515"
FT VARIANT 278
FT /note="C -> S (in dbSNP:rs6887)"
FT /id="VAR_043032"
SQ SEQUENCE 297 AA; 33695 MW; 95D3A4E0B23F60C0 CRC64;
MGEHEQVKPL ETSSSKVKAK TIVMIPDSQK LLRCELESLK SQLQAQTKAF EFLNHSVTML
EKESCLQQIK IQQLEEVLSP TGRQGEKEEH KWGMEQGRQE LYGALTQGLQ GLEKTLRDSE
EMQRARTTRC LQLLAQEIRD SKKFLWEELE LVREEVTFIY QKLQAQEDEI SENLVNIQKM
QKTQVKCRKI LTKMKQQGHE TAACPETEEI PQGASGCWKD DLQKELSDIW SAVHVLQNSI
DSLTLCSGAC PKASSLRGHK GHQCLSPPLP SWDSDSDCDQ DLSQPPFSKS GRSFPPA
